idc:Aminodeoxychorismate lyase idc:Methenyltetrahydrofolate cyclohydrolase idc:GTP cyclohydrolase idc:Hydroxymethyldihydropteridine pyrophosphokinase Dihydropteroate synthase Dihydrofolate synthase idc:Dihydrofolate reductase Thymidylate synthase Tetrahydrofolylpolyglutamate synthase Serine hydroxymethyltransferase Aminodeoxychorismate synthase Methylenetetrahydrofolate dehydrogenase Methionyl-tRNA formyltransferase idc:6-pyruvoyltetrahydro-pterin synthase GTP cyclohydrolase Aminodeoxychorismate lyase idc:Serine hydroxymethyltransferase Methenyltetrahydrofolate cyclohydrolase Hydroxymethyldihydropteridine pyrophosphokinase idc:Dihydropteroate synthase idc:Dihydrofolate synthase Dihydrofolate reductase idc:Thymidylate synthase idc:Aminodeoxychorismate synthase idc:Tetrahydrofolylpolyglutamate synthase idc:Methionyl-tRNA formyltransferase 6-pyruvoyltetrahydro-pterin synthase
   Components in the map that are indicated with a red star have relevant reagents
  in the MR4 site of ATCC.

Online articles related to Folate biosynthesis retrieved from PubMed

RX Drugs affecting pathway with unknown specific target

Drug Name PubMed Articles (year of publication)
4-[5-bromo-1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridin-3-yl]pyridin-2-amine
Aminopterin
Chlorcycloguanil
Chlorproguanil
Dapsone
Methotrexate
MMV007978
MMV665906
Proguanil
pyrimidine primaquine hybrids
Pyronaridine
Suggested target
TCMDC-124964
TCMDC-137381
TCMDC-137930
Trimetrexate
Wr99210

Folate biosynthesis map details

PFID PFID Old Annotation EC Transcript
PF3D7_0628000 PFF1360w 6-pyruvoyltetrahydro-pterin synthase 4.2.3.12 pie diagram
PF3D7_1226100 PFL1260w Alkaline phosphatase 3.1.3.1 pie diagram
PF3D7_1458400 drugs PF14_0557 Aminodeoxychorismate lyase 4.1.3.38 pie diagram
PF3D7_0922400 drugs PFI1100w Aminodeoxychorismate synthase 2.6.1.85 pie diagram
PF3D7_0417200 loop drugs PFD0830w Dihydrofolate reductase 1.5.1.3 pie diagram
PF3D7_1324800 drugs PF13_0140 Dihydrofolate synthase 6.3.2.12 pie diagram
PF3D7_0810800 drugs PF08_0095 Dihydropteroate synthase 2.5.1.15 pie diagram
PF3D7_1224000 drugs PFL1155w GTP cyclohydrolase 3.5.4.16 pie diagram
PF3D7_0810800 drugs PF08_0095 Hydroxymethyldihydropteridine pyrophosphokinase 2.7.6.3 pie diagram
PF3D7_0630700 PFF1490w Methenyltetrahydrofolate cyclohydrolase 3.5.4.9 pie diagram
PF3D7_1313200 drugs MAL13P1.67 Methionyl-tRNA formyltransferase 2.1.2.9 pie diagram
PF3D7_0630700 PFF1490w Methylenetetrahydrofolate dehydrogenase 1.5.1.5 pie diagram
PF3D7_1235600 loop drugs PFL1720w Serine hydroxymethyltransferase 2.1.2.1 pie diagram
PF3D7_1324800 drugs PF13_0140 Tetrahydrofolylpolyglutamate synthase 6.3.2.17 pie diagram
PF3D7_0417200 loop drugs PFD0830w Thymidylate synthase 2.1.1.45 pie diagram