Gene expression affected by lumefantrine
Mwai L, Diriye A, Masseno V, Muriithi S, Feltwell T, Musyoki J, Lemieux J, Feller A, Mair GR, Marsh K, Newbold C, Nzila A, Carret CK. Genome wide pressure. PLoS One. 2012;7(2):e31623. PMID: 22384044
Fold increase compared to control
PfID Annotation 0 hr 12 hrs 24 hrs 36 hrs Average EC# Transcript
PF10_0016 acyl-CoA binding protein, isoform 2, ACBP2 3.864 57.282 26.909 16.912 26.242
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PF10_0019
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early transcribed membrane protein 10.1 5.540 52.710 21.857 10.267 22.594
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MAL7P1.174 Plasmodium exported protein (PHISTb), unknown function 2.585 8.634 6.320 2.969 5.127
PF10_0017
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Plasmodium exported protein (PHISTa), unknown function 1.613 1.778 7.727 1.693 3.203
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PF10_0015 acyl-CoA binding protein, isoform 1, ACBP1 5.502 2.329 1.765 3.117 3.178
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PFD0090c
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Plasmodium exported protein (PHISTa), unknown function 0.829 3.272 5.028 1.959 2.772
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PF10_0020
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exported lipase 2 1.117 1.248 3.891 4.028 2.571 3.1.1.23
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PFF0080c tetratricopeptide repeat protein, putative 5.897 1.778 0.742 1.424 2.460
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PFB0105c liver stage associated protein 2 Plasmodium exported protein (PHISTc), unknown function 1.765 2.694 2.056 2.585 2.275
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PF14_0770 rifin 5.502 1.464 1.292 0.356 2.154
PFB0090c
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knob associated heat shock protein 40 2.462 3.294 1.376 1.275 2.102
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PFB0100c
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knob-associated histidine-rich protein 1.693 2.129 2.313 1.670 1.951
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PFA0645c 4.993 1.165 0.953 0.426 1.884
PFA0010c PIR protein rifin 3.434 1.717 1.149 0.637 1.734
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MAL7P1.175 serine/threonine protein kinase, FIKK family, pseudogene 1.602 2.313 1.729 1.133 1.694 2.7.11.1
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PFB1045w erythrocyte membrane protein 1 (PfEMP1), exon 2 2.789 1.366 1.320 0.946 1.605
PF11_0021 rifin 2.969 1.613 1.173 0.633 1.597
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PF10_0193
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autophagy-related protein 8 1.283 1.125 1.385 2.395 1.547
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PFB0045c erythrocyte membrane protein 1 (PfEMP1), truncated 2.828 1.474 1.214 0.590 1.527
PF10_0004 rifin PIR protein 2.751 1.366 1.173 0.669 1.490
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MAL13P1.8 rifin, pseudogene 2.969 1.414 1.042 0.521 1.487
PFC1120c
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erythrocyte membrane protein 1, PfEMP1 2.639 1.434 1.149 0.669 1.473
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PF14_0495
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rhoptry neck protein 2 1.214 1.072 0.865 2.585 1.434
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PFL1870c
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sphingomyelin phosphodiesterase 1.214 1.189 1.014 2.297 1.429 3.1.4.12
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PFB0085c DnaJ protein, putative 1.932 1.189 1.028 1.516 1.416
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PFC0030c rifin PIR protein 2.603 1.214 1.189 0.655 1.415
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PF13_0006
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rifin PIR protein 2.204 1.474 1.181 0.768 1.407
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PFL0015c PIR protein rifin 2.395 1.283 1.240 0.707 1.406
PF10_0094 tubulin--tyrosine ligase, putative 1.094 1.064 0.829 2.585 1.393 6.3.2.25
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PF10_0401 PIR protein rifin 2.235 1.292 0.920 0.959 1.352
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PFF0030c erythrocyte membrane protein 1 (PfEMP1), exon 2 1.495 1.840 1.320 0.747 1.351
PF07_0048 erythrocyte membrane protein 1, PfEMP1 2.158 1.338 1.117 0.758 1.343
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MAL8P1.220 erythrocyte membrane protein 1, PfEMP1 2.144 1.347 1.133 0.747 1.343
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PF14_0759 Plasmodium exported protein, unknown function, pseudogene 2.479 1.110 1.189 0.566 1.336
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PFD1005c erythrocyte membrane protein 1, PfEMP1 2.056 1.454 1.125 0.707 1.336
PF10_0406 erythrocyte membrane protein 1, PfEMP1 1.945 1.424 1.197 0.753 1.330
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PFL2665c erythrocyte membrane protein 1, PfEMP1 2.085 1.404 1.072 0.742 1.326
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PFF1365c
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HECT-domain (ubiquitin-transferase), putative 1.141 1.072 0.908 2.158 1.320 6.3.2.19
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PF14_0003 rifin 1.959 1.338 1.035 0.933 1.316
PFL1700c
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V-type K+-independent H+-translocating inorganic pyrophosphatase 1.173 1.206 0.895 1.972 1.312 3.6.1.1
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PFE1125w 50S ribosomal protein L17, apicoplast, putative 2.000 1.240 1.117 0.779 1.284
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PFA0095c PIR protein rifin 1.972 1.197 1.157 0.779 1.276
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PFA0050c rifin PIR protein 2.056 1.206 1.149 0.693 1.276
PFL2505c
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rhoptry neck protein 3 1.141 1.165 0.933 1.803 1.260
PFL1960w
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erythrocyte membrane protein 1, PfEMP1 1.790 1.283 1.102 0.818 1.248
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PFI1775w lysophospholipase, putative 1.879 1.072 1.125 0.865 1.235 3.1.1.5
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PFD0625c
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erythrocyte membrane protein 1, PfEMP1 1.803 1.214 1.087 0.812 1.229
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MAL8P1.150
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adenylyl cyclase beta 1.094 1.050 0.853 1.919 1.229 4.6.1.1
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PF07_0072
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calcium-dependent protein kinase 4 0.908 1.223 0.901 1.879 1.228 2.7.11.1
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PFI1155w
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cyclin-dependent kinases regulatory subunit, putative 1.266 0.812 1.000 1.765 1.211 3.6.5.2
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PFI0355c
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ATP-dependent protease ATPase subunit ClpY 0.895 1.072 1.181 1.670 1.204
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MAL13P1.356 erythrocyte membrane protein 1, PfEMP1 1.591 1.283 1.087 0.847 1.202
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PFC0840w P-type ATPase, putative 1.257 0.835 1.094 1.613 1.200 3.6.3.1
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PFI0785c
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major facilitator superfamily domain-containing protein 1.157 1.125 0.993 1.516 1.198
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PFA0005w
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erythrocyte membrane protein 1, PfEMP1 1.815 1.149 1.028 0.779 1.193
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MAL8P1.82 vacuolar protein sorting-associated protein 9, putative 1.117 1.000 1.028 1.613 1.190
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PF11_0172
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folate transporter 2 0.646 0.895 1.424 1.790 1.189
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PF13_0285
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phosphoinositide phosphatase sac1 0.953 1.110 1.050 1.613 1.181 3.1.3.56
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PF10_0005 rifin PIR protein 1.636 1.165 1.050 0.812 1.166
MAL7P1.56 erythrocyte membrane protein 1, PfEMP1 1.569 1.181 1.072 0.829 1.163
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PFE0420c guanidine nucleotide exchange factor 1.117 1.035 0.901 1.558 1.153
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PFA0590w
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multidrug resistance-associated protein 1 ABC transporter C family member 1 0.946 0.796 1.591 1.248 1.145 3.6.3.44
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PFC0005w erythrocyte membrane protein 1, PfEMP1 1.558 1.133 1.050 0.835 1.144
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PF14_0143
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atypical protein kinase, ABC-1 family, putative 0.979 1.050 0.973 1.548 1.137 1.14.13.-
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MAL13P1.21 condensin complex subunit 2, putative 1.087 0.847 1.035 1.548 1.129
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PF11_0464 serine/threonine protein kinase, putative 1.102 1.007 0.841 1.505 1.114 2.7.11.1
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PFI0920c dihydrouridine synthase, putative 1.214 1.189 1.125 0.497 1.006 1.3.1.42
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PF13_0049 60S ribosomal protein L24, putative 0.624 1.141 1.057 1.064 0.972
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MaL13P1.80 zinc finger (CCCH type) protein, putative 0.574 0.986 1.072 1.206 0.960
PFI1370c
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phosphatidylserine decarboxylase 0.586 1.021 0.914 1.301 0.956 4.1.1.65
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MAL13P1.190 26S proteasome regulatory subunit RPN3, putative 0.511 0.933 0.966 1.338 0.937
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PF14_0020
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choline kinase 0.374 0.908 1.028 1.434 0.936 2.7.1.32
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PFB0445c
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ATP-dependent RNA helicase UAP56 0.616 1.149 1.057 0.908 0.932 3.6.4.13
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PFC0395w asparagine synthetase [glutamine-hydrolyzing], putative 0.607 1.102 1.173 0.812 0.924 6.3.5.4
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MAL13P1.271 V-type proton ATPase 21 kDa proteolipid subunit, putative 0.555 0.824 1.057 1.248 0.921 3.6.3.14
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PF13_0310 sas10 domain-containing protein, putative 0.655 0.895 0.986 1.050 0.897
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PFL1645w bromodomain protein, putative 0.669 0.847 0.953 1.117 0.896
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PF10_0104 dolichyl-phosphate-mannose-protein mannosyltransferase, putative 0.620 0.927 1.007 1.028 0.895 2.4.1.109
PFC0340w DNA polymerase delta small subunit, putative 1.007 0.566 0.973 1.035 0.895 2.7.7.7
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PF11_0458 transcription initiation factor IIF subunit beta, putative 0.651 1.057 0.973 0.883 0.891
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MAL7P1.139 mago nashi protein homologue, putative 0.536 0.966 1.000 1.057 0.890
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PFE0790c
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BolA-like protein, putative 0.540 0.824 1.064 1.117 0.886
PF11_0447 translation initiation factor eIF-1A, putative 0.633 0.920 0.953 1.035 0.885
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PFE0595w prefoldin subunit 6, putative 0.664 0.853 0.993 1.021 0.883
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PF08_0031
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dicarboxylate/tricarboxylate carrier 0.356 0.529 1.079 1.537 0.875
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MAL13P1.283
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T-complex protein 1 subunit delta 0.646 0.966 1.087 0.801 0.875
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MAL13P1.76
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general transcription factor IIH subunit 2 0.655 0.889 1.064 0.889 0.874
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PFD0440w
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tRNA N6-adenosine threonylcarbamoyltransferase 0.966 0.620 0.901 1.000 0.872 2.6.99.4
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PF10_0127 zinc finger protein, putative 0.669 0.973 0.908 0.933 0.871
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PFE0055c
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heat shock protein 40, type II 0.883 1.110 0.959 0.514 0.866
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PFE0885w eukaryotic translation initiation factor 3 subunit B, putative 0.651 0.914 1.102 0.796 0.865
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PF11_0051
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phenylalanine--tRNA ligase beta subunit 0.633 0.807 1.007 1.014 0.865 6.1.1.20
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PFB0245c DNA-directed RNA polymerase II 16 kDa subunit, putative 0.603 1.079 0.914 0.853 0.862 2.7.7.6
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PF07_0088 40S ribosomal protein S5, putative 0.480 1.064 1.125 0.779 0.862
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PF13_0300 mitochondrial import inner membrane translocase subunit TIM23, putative 0.521 0.742 1.173 1.000 0.859
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PFC0725c
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formate-nitrite transporter 0.532 0.889 1.028 0.986 0.859
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PF11_0400 WD repeat-containing protein, putative 0.633 0.973 0.895 0.933 0.858
PF08_0124 cactin homolog, putative 0.642 0.914 1.007 0.871 0.858
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PF14_0439
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M17 leucyl aminopeptidase 0.525 0.865 1.240 0.790 0.855 3.4.11.1
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PF11_0043
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60S acidic ribosomal protein P1, putative 0.660 0.818 0.946 0.986 0.852
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PF14_0429 ATP-dependent RNA helicase MAK5, putative 0.555 0.986 0.973 0.889 0.851 3.6.4.13
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PFE0285c
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small ubiquitin-related modifier 0.463 0.818 0.901 1.197 0.845
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PFD0835c LETM1-like protein, putative 0.551 1.007 0.959 0.859 0.844
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MAL8P1.142
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proteasome subunit beta type-4 0.390 0.901 0.859 1.223 0.843 3.4.25.1
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MAL8P1.9 U6 snRNA-associated Sm-like protein LSm8, putative 0.590 1.072 0.959 0.737 0.840
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PFL2275c
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peptidyl-prolyl cis-trans isomerase fkbp 0.366 0.633 0.993 1.366 0.840 5.2.1.8
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MAL13P1.93 nucleolar complex protein 4, putative 0.529 0.986 0.959 0.871 0.836
PFC0900w T-complex protein 1 subunit epsilon 0.607 0.768 1.007 0.946 0.832
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PF13_0051 H/ACA ribonucleoprotein complex subunit 1, putative 0.669 0.871 0.914 0.859 0.828
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PFE1240w S-adenosyl-l-methionine-dependent trna 4-demethylwyosine synthase, putative 0.514 0.986 0.953 0.853 0.826
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PF14_0627 40S ribosomal protein S3 0.603 0.889 1.028 0.774 0.823
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PFC0282w ER membrane protein complex subunit 5, putative 0.582 0.986 0.933 0.790 0.823
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PF14_0231 60S ribosomal protein L7-3, putative 0.500 0.933 0.966 0.889 0.822
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PF13_0214 elongation factor 1-gamma, putative 0.551 0.877 1.000 0.853 0.820
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PF10_0160
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serine/threonine protein kinase, FIKK family 0.547 0.859 1.050 0.824 0.820 2.7.11.1
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MAL13P1.82
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CDP-diacylglycerol--inositol 3-phosphatidyltransferase phosphatidylinositol synthase 0.547 0.651 0.841 1.223 0.815 2.7.8.11
PF14_0242
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protein arginine N-methyltransferase 1 0.463 0.829 0.973 0.986 0.813 2.1.1.125
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PFE1035c
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bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] Ap4A hydrolase 0.507 0.940 0.979 0.824 0.812 3.6.1.17
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PF14_0078
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plasmepsin III histo-aspartic protease 0.582 0.883 1.007 0.768 0.810 3.4.23.-
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PF14_0424 shikimate dehydrogenase, putative 0.480 0.763 1.050 0.933 0.806 1.1.1.25
PFI0720w
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major facilitator superfamily-related transporter 0.993 0.753 0.877 0.586 0.802
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PF13_0282 proteasome subunit alpha type-4, putative 0.611 0.722 0.829 1.042 0.801 3.4.25.1
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PF13_0128
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beta-hydroxyacyl-ACP dehydratase 0.248 1.133 0.993 0.829 0.801 4.2.1.59