Signifcantly altered metabolic genes  in response to hypoxanthine deprivation
Tewari SG, Rajaram K, Schyman P, Swift R, Reifman J, Prigge ST, Wallqvist A. Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability. Malar J. 2019 18(1):86.PMID: 30890151.
Functional category PfID Annotation EC# Transcript Altered within 24 hrs Altered after 24 hrs
40135 Translation PF3D7_1218600
arginine-tRNA ligase; arginyl-tRNA synthetase 6.1.1.19
+
40087 PF3D7_0925300
proline--tRNA ligase, putative 6.1.1.15
+
40132 PF3D7_1213800
prolyl-tRNA synthetase proline--tRNA ligase 6.1.1.15
+
40135 PF3D7_1218600
arginine-tRNA ligase; arginyl-tRNA synthetase 6.1.1.19
+
40023 PF3D7_0102900
aspartate--tRNA ligase 6.1.1.12
+
40034 PF3D7_0211800 asparagine--tRNA ligase 6.1.1.22
+
40045 PF3D7_0509600
asparagine--tRNA ligase 6.1.1.22
+
40048 PF3D7_0514300 aspartate--tRNA ligase, putative 6.1.1.12
+
40167 PF3D7_1357200
glutamate--tRNA ligase 6.1.1.17
+
40154 PF3D7_1331700
glutamine--tRNA ligase, putative 6.1.1.18
+
40163 PF3D7_1349200 glutamate--tRNA ligase, putative 6.1.1.17
+
40183 PF3D7_1420400
glycine--tRNA ligase 6.1.1.14
+
40079 PF3D7_0828200 leucine--tRNA ligase, putative 6.1.1.4
+
40155 PF3D7_1332900
isoleucine--tRNA ligase, putative 6.1.1.5
+
40204 PF3D7_1461900
valine--tRNA ligase, putative 6.1.1.9
+
40037 PF3D7_0311200 valine--tRNA ligase, putative 6.1.1.9
+
40060 PF3D7_0622800
leucine--tRNA ligase, putative 6.1.1.4
+
40165 PF3D7_1350100
lysine--tRNA ligase 6.1.1.6
+
40181 PF3D7_1416800
lysine--tRNA ligase, putative 6.1.1.6
+
40093 PF3D7_1005000
methionine--tRNA ligase, putative 6.1.1.10
+
40106 PF3D7_1034900
methionine--tRNA ligase 6.1.1.10
+
40071 PF3D7_0807900
tyrosine--tRNA ligase 6.1.1.1
+
40109 PF3D7_1104000
phenylalanine--tRNA ligase beta subunit 6.1.1.20
+
40115 PF3D7_1117500
tyrosine--tRNA ligase 6.1.1.1
+
40156 PF3D7_1336900
tryptophanyl-tRNA synthetase tryptophan--tRNA ligase 6.1.1.2
+
40027 PF3D7_0109800
phenylalanyl-tRNA synthetase alpha subunit 6.1.1.20
+
40052 PF3D7_0603700
phenylalanine--tRNA ligase 6.1.1.20
+
40138 PF3D7_1232000
phenylalanine--tRNA ligase 6.1.1.20
+
40068 PF3D7_0717700
serine--tRNA ligase, putative 6.1.1.11
+
40134 PF3D7_1216000 serine--tRNA ligase, putative 6.1.1.11
+
40097 PF3D7_1015200
cysteine--tRNA ligase, putative 6.1.1.16
+
40118 PF3D7_1126000
threonine--tRNA ligase 6.1.1.3
+
40174 PF3D7_1367700
alanine--tRNA ligase 6.1.1.7
+
40198 PF3D7_1445100 histidine--tRNA ligase, putative 6.1.1.21
+
40082 Invasion PF3D7_0918000
glideosome-associated protein 50 secreted acid phosphatase 3.1.3.2
+
40080 Post-translation PF3D7_0831800
histidine-rich protein II + +
40112 PF3D7_1115300
falcipain 2' cysteine proteinase falcipain 2b 3.4.22.-
+
40113 PF3D7_1115400
cysteine proteinase falcipain 3 3.4.22.-
+
40114 PF3D7_1115700
cysteine proteinase falcipain 2a falcipain 2 3.4.22.-
+
40177 PF3D7_1407900
plasmepsin I 3.4.23.38
+
40178 PF3D7_1408000
plasmepsin II 3.4.23.39
+
40168 Amino acid metabolism PF3D7_1357900 pyrroline-5-carboxylate reductase, putative 1.5.1.2
+ +
40056 PF3D7_0608800
ornithine aminotransferase 2.6.1.13
+ +
40081 PF3D7_0906500
arginase 3.5.3.1
+ +
40070 PF3D7_0802000
glutamate dehydrogenase, putative 1.4.1.2
+
40180 PF3D7_1416500
NADP-specific glutamate dehydrogenase 1.4.1.4
+
40074 PF3D7_0815900
dihydrolipoyl dehydrogenase, apicoplast 1.1.1.35
+ +
40172 PF3D7_1365500
glycine cleavage system T protein, putative aminomethyltransferase, mitochondrial, putative 2.1.2.10
+
40104 PF3D7_1033100
S-adenosylmethionine decarboxylase/ornithine decarboxylase 4.1.1.17
+
40050 PF3D7_0520900
S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 3.3.1.1
+ +
40084 PF3D7_0922200
S-adenosylmethionine synthetase 2.5.1.6
+
40088 PF3D7_0926700
glutamine-dependent NAD(+) synthetase, putative 6.3.5.1
+
40121 PF3D7_1129000
spermidine synthase 2.5.1.16
+
40038 Carbohydrate metabolism PF3D7_0318800
triosephosphate isomerase, putative 5.3.1.1
+
40201 PF3D7_1453800
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 1.1.1.49
+ +
40202 PF3D7_1454700
6-phosphogluconate dehydrogenase, decarboxylating, putative 1.1.1.44
+ +
40057 PF3D7_0610800
transketolase 2.2.1.1
+
40136 PF3D7_1219900
ribulose-phosphate 3-epimerase, putative 5.1.3.1
+
40095 PF3D7_1012500 phosphoglucomutase, putative 5.4.2.2
+
40107 PF3D7_1037100
pyruvate kinase 2, pyrkii 2.7.1.40
+
40159 PF3D7_1342800
phosphoenolpyruvate carboxykinase 4.1.1.49
+ +
40185 PF3D7_1426700
phosphoenolpyruvate carboxylase 4.1.1.31
+
40103 Nucleotide metabolism PF3D7_1029600
adenosine deaminase 3.5.4.4
+ +
40047 PF3D7_0513300
purine nucleoside phosphorylase 2.4.2.1
+ +
40031 PF3D7_0206700
adenylosuccinate lyase 4.3.2.2
+
40166 PF3D7_1354500
adenylosuccinate synthetase 6.3.4.4
+
40170 PF3D7_1360500 guanylyl cyclase beta 4.6.1.2
+
40123 PF3D7_1138400
guanylyl cyclase alfa Gca 4.6.1.2
+
40119 PF3D7_1127100
deoxyuridine 5'-triphosphate nucleotidohydrolase dUTP pyrophosphatase 3.6.1.23
+
40164 PF3D7_1349400 cytidine and deoxycytidylate deaminase, putative 3.5.4.5
+
40144 PF3D7_1251300
thymidylate kinase 2.7.4.9 +
40173 PF3D7_1366500
nucleoside diphosphate kinase 2.7.4.6
+
40053 PF3D7_0605600
nucleoside diphosphate kinase, putative 2.7.4.6
+
40098 PF3D7_1015800
ribonucleoside-diphosphate reductase small chain, putative 1.17.4.1
+
40176 PF3D7_1405600
ribonucleoside-diphosphate reductase small chain, putative 1.17.4.1
+
40190 PF3D7_1437200
ribonucleoside-diphosphate reductase large subunit, putative 1.17.4.1
+
40151 PF3D7_1321500
3',5'-cyclic nucleotide phosphodiesterase beta 3.1.4.17
+
40152 PF3D7_1321600
cGMP-specific 3',5'-cyclic phosphodiesterase gamma, putative 3.1.4.17
+
40094 PF3D7_1012400
hypoxanthine-guanine phosphoribosyltransferase 2.4.2.8
+
40207 PF3D7_1470500
cgmp-specific 3',5'-cyclic phosphodiesterase delta, putative 3.1.4.17
+
40126 PF3D7_1206100
imp-specific 5'-nucleotidase 1 3.1.3.5
+
40128 PF3D7_1209500
cGMP-specific 3',5'-cyclic phosphodiesterase alpha 3.1.4.35
+
40160 Lipid metabolism PF3D7_1343000
phosphoethanolamine N-methyltransferase 2.1.1.103
+ +
MAL6P1.97 +
40149 PF3D7_1318200
glycerol-3-phosphate 1-O-acyltransferase, putative 2.3.1.15
+
40197 PF3D7_1444300 1-acyl-sn-glycerol-3-phosphate acyltransferase, putative 2.3.1.51
+
40208 PF3D7_1471400 diacylglycerol kinase, putative 2.7.1.107
+
40092 PF3D7_0930500 diacylglycerol kinase, putative 2.7.1.107
+
40157 PF3D7_1337200
1-deoxy-D-xylulose 5-phosphate synthase 2.2.1.7
+
40101 PF3D7_1022800
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin), putative 1.17.7.1
+
40205 PF3D7_1467300
1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267
+
40025 PF3D7_0104400
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1.17.1.2
+
40026 PF3D7_0106900
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative 2.7.7.60
+
40032 PF3D7_0209300
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12
+
40043 PF3D7_0503100
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 2.7.1.148
+
40175 PF3D7_1401800
choline kinase 2.7.1.32
+
40075 PF3D7_0820200 phosphatidylglycerophosphate synthase 2.7.8.5
+
40117 PF3D7_1124600
ethanolamine kinase 2.7.1.82
+ +
40179 PF3D7_1409900
cytidine diphosphate-diacylglycerol synthase 2.7.7.41
+
40208 PF3D7_1471400 diacylglycerol kinase, putative 2.7.1.107
+
40092 PF3D7_0930500 diacylglycerol kinase, putative 2.7.1.107
+
40120 PF3D7_1128400
geranylgeranyl pyrophosphate synthase, putative 2.5.1.29
+
40040 PF3D7_0322300
diacylglycerol O-acyltransferase 2.3.1.20
+ +
40131 PF3D7_1212500
glycerol-3-phosphate 1-O-acyltransferase 2.3.1.15
+ +
40046 Redox metabolism PF3D7_0512200
glutathione synthetase 6.3.2.3
+ +
40083 PF3D7_0918900
gamma-glutamylcysteine synthetase 6.3.2.2
+ +
40072 PF3D7_0814900
superoxide dismutase [Fe] 1.15.1.1
+ +
40192 PF3D7_1438900
thioredoxin peroxidase 1 1.11.1.15
+ +
40062 PF3D7_0623500
superoxide dismutase [Fe] 1.15.1.1 + +
40130 PF3D7_1212000
glutathione peroxidase-like thioredoxin peroxidase 1.11.1.9
+ +
40133 PF3D7_1215000
thioredoxin peroxidase 2 1.11.1.15
+ +
40182 PF3D7_1419800
glutathione reductase 1.8.1.7
+
40085 PF3D7_0923800
thioredoxin reductase 1.8.1.9
+ +
40029 Cofactor biosynthesis PF3D7_0204500
aspartate transaminase 2.6.1.1
+ +
40143 PF3D7_1246100
delta-aminolevulinic acid synthetase 2.3.1.37
+
40188 PF3D7_1431600 succinyl-CoA ligase [ADP-forming] subunit beta 6.2.1.5
+
40065 PF3D7_0704700
phosphopantetheine adenylyltransferase, putative 2.7.7.3
+
40108 PF3D7_1102400 phosphopantothenate-cysteine ligase, putative 6.3.2.5
+
40184 PF3D7_1420600
pantothenate kinase 1 2.7.1.33
+
40191 PF3D7_1437400
pantothenate kinase 2 2.7.1.33
+
40196 PF3D7_1443700
dephospho-CoA kinase 2.7.1.24
+
40041 PF3D7_0412300 phosphopantothenoylcysteine synthetase, putative 6.3.2.5
+
40042 PF3D7_0417200
bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3
+
40153 PF3D7_1327600
nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2.7.7.18 +
40200 PF3D7_1453500 NAD(P) transhydrogenase, putative, nth 1.6.1.1
+ +
40039 PF3D7_0320500
nicotinamidase, putative 3.5.1.19
+
40063 PF3D7_0629100
nicotinate phosphoribosyltransferase, putative 6.3.4.21
+
40171 PF3D7_1364900
ferrochelatase, HemH 4.99.1.1
+
40102 PF3D7_1028100
protoporphyrinogen oxidase 1.3.3.4
+
40124 PF3D7_1142400
coproporphyrinogen-III oxidase HemF 1.3.3.3
+
40194 PF3D7_1440300
delta-aminolevulinic acid dehydratase porphobilinogen synthase, HemB 4.2.1.24
+
40054 PF3D7_0607300
uroporphyrinogen III decarboxylase 4.1.1.37
+
40129 PF3D7_1209600
porphobilinogen deaminase 2.5.1.61
+
40169 PF3D7_1359100 riboflavin kinase, putative 2.7.1.26 +
40096 PF3D7_1015000
FAD synthetase, putative 2.7.7.2
+
40212 PF3D7_0206400 pentafunctional AROM polypeptide, putative, pseudogene
+
40061 PF3D7_0623000
chorismate synthase 4.2.3.5
+
40086 PF3D7_0924300
thiamine pyrophosphokinase 2.7.6.2
+
40069 PF3D7_0724300 3-demethylubiquinone-9 3-methyltransferase, putative 2.1.1.64
+
40073 PF3D7_0815300
FAD-dependent monooxygenase, putative 1.14.13.8
+
40030 PF3D7_0204900 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial, putative 2.1.1.201
+
40055 PF3D7_0607500
4-hydroxybenzoate polyprenyltransferase, putative 2.5.1.39
+
40145 PF3D7_1308200
carbamoyl phosphate synthetase 6.3.5.5
+ +
40203 PF3D7_1456100
serine hydroxymethyltransferase 2.1.2.1
+
40140 PF3D7_1235600
serine hydroxymethyltransferase 2.1.2.1
+
40042 PF3D7_0417200
bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3
+
40195 Transport PF3D7_1442300
tRNA import protein tRIP
+
40028 PF3D7_0112200
multidrug resistance-associated protein 1 MRP1 3.6.3.44
+ +
40078 PF3D7_0824400
nucleoside transporter 2, NT2
+
40162 PF3D7_1347200
nucleoside transporter 1, NT1
+
40206 PF3D7_1469400 nucleoside transporter 3, putative, NT3
+
40024 PF3D7_0103200
nucleoside transporter 4, NT4
+
40110 PF3D7_1104800 metabolite/drug transporter, putative + +
40122 PF3D7_1132500 amino acid transporter, putative
+ +
40033 PF3D7_0209600 transporter, putative
+ +
40049 PF3D7_0515500 gametogenesis essential protein 1, putative, gep1
+ +
40064 PF3D7_0629500
amino acid transporter aat1
+ +
40127 PF3D7_1208400 amino acid transporter, putative
+ +
40137 PF3D7_1231400
membrane protein icm1
+ +
40044 PF3D7_0508300
triose phosphate transporter, TPT
+
40051 PF3D7_0530200
phosphoenolpyruvate/phosphate translocator, PPT
+
40077 PF3D7_0823900
dicarboxylate/tricarboxylate carrier, DTC
+
40142 PF3D7_1241600 S-adenosylmethionine mitochondrial carrier protein, SAMC
+
40146 PF3D7_1310000
ATP synthase subunit o, mitochondrial, putative 3.6.3.14
+
40066 PF3D7_0705900
ATP synthase subunit C, putative 3.6.3.14
+
40067 PF3D7_0715500
ATP synthase subunit epsilon, mitochondrial, putative 3.6.3.14 +
40125 PF3D7_1147700
ATP synthase subunit delta, mitochondrial, putative 3.6.3.14
+
40147 PF3D7_1311300
ATP synthase subunit gamma, mitochondrial 3.6.3.14
+
40035 PF3D7_0217100
ATP synthase subunit alpha, mitochondrial 3.6.3.14
+
40141 PF3D7_1235700
ATP synthase subunit beta, mitochondrial 3.6.3.14
+
40139 Organellar functions PF3D7_1232200
dihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4
+ +
40058 PF3D7_0616800
malate:quinone oxidoreductase, putative 1.1.5.4
+ +
40099 PF3D7_1020800
dihydrolipoamide acyltransferase component E2 2.3.1.12
+
40116 PF3D7_1124500
pyruvate dehydrogenase E1 component subunit alpha 1.2.4.1
+
40199 PF3D7_1446400
pyruvate dehydrogenase E1 component subunit beta 1.2.4.1
+
40036 PF3D7_0303700
lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 2.3.1.168
+
40090 PF3D7_0927800 COX5B cytochrome c oxidase subunit 5B, putative 1.9.3.1 +
40091 PF3D7_0928000 COX6b cytochrome c oxidase subunit 6B, putative 1.9.3.1 +
40111 PF3D7_1114800
glycerol-3-phosphate dehydrogenase, putative 1.1.1.8
+
40211 mal_mito_2 COX 1 cytochrome c oxidase subunit I 1.9.3.1
+ +
40210 mal_mito_1
COX3 cytochrome c oxidase subunit 3 1.9.3.1
+ +
40105 PF3D7_1034400
flavoprotein subunit of succinate dehydrogenase 1.3.5.1
+ +
40186 PF3D7_1426900
cytochrome b-c1 complex subunit 6, putative 1.10.2.2
+ +
40187 PF3D7_1430900 cytochrome c oxidase subunit 2b, putative 1.9.3.1
+ +
40189 PF3D7_1435000 cytochrome c oxidase assembly protein cox15
+ +
40193 PF3D7_1439400
cytochrome b-c1 complex subunit Rieske, putative 1.10.2.2
+ +
40209 PF3D7_1475300
COX11 cytochrome c oxidase assembly protein  putative 1.9.3.1
+ +
40074 PF3D7_0815900
dihydrolipoyl dehydrogenase, apicoplast 1.1.1.35
+
40100 PF3D7_1022500
citrate synthase, mitochondrial, putative 2.3.3.1
+
40076 PF3D7_0820700
2-oxoglutarate dehydrogenase E1 component 1.2.4.2
+
40148 PF3D7_1312600
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial, putative 1.2.4.4
+
40158 PF3D7_1342100
aconitate hydratase 4.2.1.3
+
40161 PF3D7_1345700 isocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42
+
40150 PF3D7_1320800
dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2.3.1.61
+
40158 PF3D7_1342100
aconitate hydratase 4.2.1.3
+ +
40059 PF3D7_0618500
malate dehydrogenase 1.1.1.37
+
40089 PF3D7_0927300
fumarate hydratase 4.2.1.2
+ +
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