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LysoPC depletion induces gene activity |
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Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth DF, Gendaszewska-Darmach E, Duraisingh MT, Adams JH, Voss TS, Waters AP, Jiang RHY, Clardy J, Marti M. Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. Cell. 2017 Nov 2. pii: S0092-8674(17)31242-4. PMID: 29129376. |
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GO-classified |
PfID |
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Annotation |
Induction score |
E.C |
Transcript |
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| 27351 |
PC biosynthesis |
PF3D7_1343000 |
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phosphoethanolamine N-methyltransferase |
5.92 |
2.1.1.103 |
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| 27329 |
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PF3D7_0922200 |
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S-adenosylmethionine synthetase |
4.72 |
2.5.1.6 |
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| 27322 |
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PF3D7_0520900 |
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S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase |
4.17 |
3.3.1.1 |
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| 27337 |
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PF3D7_1124600 |
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ethanolamine kinase |
3.13 |
2.7.1.82 |
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| 27350 |
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PF3D7_1332500 |
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SAM-dependent RNA methyltransferase, putative |
2.15 |
2.1.1.220 |
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| 27332 |
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PF3D7_0935400 |
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gametocyte development protein 1 |
4.10 |
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| 27349 |
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PF3D7_1328800 |
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transcriptional regulatory protein sir2a |
1.51 |
3.5.1.98 |
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| 27334 |
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PF3D7_1114700 |
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cyclin-dependent-like kinase clk3 |
1.44 |
2.7.11.1 |
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| 27318 |
DNA replication |
PF3D7_0309200 |
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serine/threonine protein kinase ark2, putative |
3.99 |
2.7.11.1 |
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| 27344 |
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PF3D7_1227500 |
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protein soc2, putative |
3.43 |
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| 27321 |
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PF3D7_0509100 |
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structural maintenance of chromosomes protein 4 |
3.19 |
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| 27324 |
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PF3D7_0625300 |
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mitochondrial DNA polymerase |
2.62 |
2.7.7.7 |
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| 27340 |
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PF3D7_1211300 |
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DNA helicase MCM8, putative |
2.06 |
3.6.4.12 |
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| 27316 |
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PF3D7_0111300 |
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p-loop containing nucleoside triphosphate hydrolase, putative |
1.95 |
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| 27339 |
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PF3D7_1203000 |
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origin recognition complex subunit 1 |
1.48 |
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| 27331 |
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PF3D7_0928800 |
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serine/threonine protein kinase, putative |
2.57 |
2.7.11.1 |
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| 27330 |
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PF3D7_0926100 |
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protein kinase, putative |
2.43 |
2.7.11.1 |
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| 27317 |
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PF3D7_0211700 |
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tyrosine kinase-like protein, putative |
2.24 |
2.7.11.1 |
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| 27335 |
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PF3D7_1121300 |
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tyrosine kinase-like protein |
2.15 |
2.7.10.2 |
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| 27325 |
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PF3D7_0705000 |
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mrna cap guanine-n7 methyltransferase, putative |
2.43 |
2.1.1.56 |
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| 27333 |
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PF3D7_1008000 |
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histone deacetylase 2 |
2.15 |
3.5.1.98 |
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| 27341 |
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PF3D7_1211600 |
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lysine-specific histone demethylase 1, putative |
2.03 |
1.14.11.27 |
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| 27346 |
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PF3D7_1233700 |
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homocysteine S-methyltransferase, putative |
1.93 |
2.1.1.10 |
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| 27336 |
Macromolecules modification |
PF3D7_1123100 |
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calcium-dependent protein kinase 7 |
3.46 |
2.7.11.17 |
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| 27352 |
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PF3D7_1431500 |
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mitogen-activated protein kinase 1 |
2.77 |
2.7.11.24 |
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| 27320 |
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PF3D7_0419900 |
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phosphatidylinositol 4-kinase, putative |
2.10 |
2.7.1.67 |
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| 27338 |
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PF3D7_1145200 |
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serine/threonine protein kinase, putative |
2.09 |
2.7.11.1 |
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| 27348 |
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PF3D7_1316100 |
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inositol polyphosphate kinase, putative |
1.88 |
2.7.1.151 |
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| 27347 |
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PF3D7_1247500 |
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serine/threonine protein kinase, putative |
2.23 |
2.7.11.1 |
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| 33708 |
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PF3D7_0705300 |
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mediator of RNA polymerase ii transcription subunit 10, putative |
3.41 |
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| 27328 |
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PF3D7_0919900 |
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regulator of chromosome condensation, putative |
2.50 |
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| 27323 |
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PF3D7_0615500 |
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cdc2-related protein kinase 5 |
2.33 |
2.7.11.22 |
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| 27345 |
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PF3D7_1227600 |
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kinetochore protein SPC24, putative |
2.07 |
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| 27319 |
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PF3D7_0317200 |
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cdc2-related protein kinase 4 |
1.62 |
2.7.11.22 |
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| 27343 |
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PF3D7_1222600 |
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AP2 domain transcription factor AP-G |
7.54 |
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| 27342 |
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PF3D7_1221000 |
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histone-lysine N-methyltransferase, H3 lysine-4 specific |
2.55 |
2.1.1.43 |
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| 27327 |
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PF3D7_0827800 |
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SET domain protein, putative |
2.19 |
2.1.1.43 |
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The expression of more than 300 genes was found to be modified by LysoPC deprivation |
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