LysoPC depletion induces gene activity
Brancucci NMB, Gerdt JP, Wang C, De Niz M, Philip N, Adapa SR, Zhang M, Hitz E, Niederwieser I, Boltryk SD, Laffitte MC, Clark MA, Grüring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth DF, Gendaszewska-Darmach E, Duraisingh MT, Adams JH, Voss TS, Waters AP, Jiang RHY, Clardy J, Marti M. Lysophosphatidylcholine Regulates Sexual Stage Differentiation in the Human Malaria Parasite Plasmodium falciparum. Cell. 2017 Nov 2. pii: S0092-8674(17)31242-4. PMID: 29129376.
GO-classified PfID Annotation Induction score E.C Transcript
PC biosynthesis PF3D7_1343000
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phosphoethanolamine N-methyltransferase 5.92 2.1.1.103
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PF3D7_0922200
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S-adenosylmethionine synthetase 4.72 2.5.1.6
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PF3D7_0520900
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S-adenosyl-L-homocysteine hydrolase adenosylhomocysteinase 4.17 3.3.1.1
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PF3D7_1124600
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ethanolamine kinase 3.13 2.7.1.82
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PF3D7_1332500 SAM-dependent RNA methyltransferase, putative 2.15 2.1.1.220
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PF3D7_0935400
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gametocyte development protein 1 4.10
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PF3D7_1328800
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transcriptional regulatory protein sir2a 1.51 3.5.1.98
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PF3D7_1114700
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serine/threonine protein kinase, putative 1.44 2.7.11.1
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DNA replication PF3D7_0309200
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serine/threonine protein kinase, putative 3.99 2.7.11.1
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PF3D7_1227500 protein soc2, putative 3.43
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PF3D7_0509100
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structural maintenance of chromosomes protein 4, putative 3.19
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PF3D7_0625300
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DNA polymerase 1, putative 2.62 2.7.7.7
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PF3D7_1211300 DNA helicase MCM8, putative 2.06 3.6.4.12
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PF3D7_0111300
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p-loop containing nucleoside triphosphate hydrolase, putative 1.95
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PF3D7_1203000
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origin recognition complex subunit 1 1.48
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PF3D7_0928800 serine/threonine protein kinase, putative 2.57 2.7.11.1
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PF3D7_0926100 protein kinase, putative 2.43 2.7.11.1
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PF3D7_0211700
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tyrosine kinase-like protein, putative 2.24 2.7.11.1
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PF3D7_1121300
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tyrosine kinase-like protein 2.15 2.7.10.2
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PF3D7_0705000 mRNA cap guanine-n7 methyltransferase, putative 2.43 2.1.1.56
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PF3D7_1008000
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histone deacetylase 2 2.15 3.5.1.98
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PF3D7_1211600
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lysine-specific histone demethylase 1, putative 2.03 1.14.11.27
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PF3D7_1233700 homocysteine S-methyltransferase, putative 1.93 2.1.1.10
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Macromolecules modification PF3D7_1123100
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calcium-dependent protein kinase 7 3.46 2.7.11.17
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PF3D7_1431500
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mitogen-activated protein kinase 1 2.77 2.7.11.24
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PF3D7_0419900 phosphatidylinositol 4-kinase, putative 2.10 2.7.1.67
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PF3D7_1145200 serine/threonine protein kinase, putative 2.09 2.7.11.1
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PF3D7_1316100 inositol polyphosphate kinase, putative 1.88 2.7.1.151
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PF3D7_1247500
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serine/threonine protein kinase, putative 2.23 2.7.11.1
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PF3D7_0705300
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mediator of RNA polymerase ii transcription subunit 10, putative 3.41
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PF3D7_0919900 regulator of chromosome condensation, putative 2.50
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PF3D7_0615500 cdc2-related protein kinase 5 2.33 2.7.11.22
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PF3D7_1227600 conserved plasmodium protein, unknown function 2.07
PF3D7_0317200
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cdc2-related protein kinase 4 1.62 2.7.11.22
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PF3D7_1222600 AP2 domain transcription factor AP-g 7.54
PF3D7_1221000
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histone-lysine N-methyltransferase, H3 lysine-4 specific 2.55 2.1.1.43
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PF3D7_0827800
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SET domain protein, putative 2.19 2.1.1.43
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The expression of more than 300 genes was found to be modified by LysoPC deprivation
Online articles related to LysoPC depletion induces gene activity retrieved from PubMed