Antimalarial activity of plant metabolites
Schwikkard S, van Heerden FR. Antimalarial activity of plant metabolites. Nat Prod Rep. 2002 Dec;19(6):675-92. Review. PubMed PMID: 12521264.
Family Species Compound IC50  (μg/ml)) strain
Amaryllidaceae Brunsvigia littoralis Lycorine (5) 0.062 D10
1,2-Di-O-acetyllycorine (6) 1 D10
Crinamine (7) 2.8 D10
Crinum amabile  Augustine (8) 0.18 W2
Anacardiaceae Rhus retinorrhoea 7,7”-Di-O-methyltetra-hydromentoflavone (9) 0.98 W2
Swintonia foxworthyi Methyl gallate 2 W2
Methyl digallate 4.6 W2
Dioncophyllaceae, Triphyophyllum peltatum Dioncophylline C (10) 0.014 NF 54
Dioncopeltine A (11) 0.021 NF 54
7-Epidioncophylline A (12) 0.19 NF 54
Dioncophylline B (13) 0.063 K1
Dioncophylline A (14) 0.086 K1
Ancistrocladaceae  Ancistrocladus korupensis Korundamine A (15) 1.1
Korupensamine B (16) 0.18
Yaoundamine A (17) 2.2 NF 54
Triphyophyllum peltatum Betulinic acid 10.46 NF 54
Annonaceae  Duguetia hadrantha Sampangine (20) 0.068 W2
3-Methoxysampagine (21) 0.095 W2
Uvaria spp. Uvaretin (22) 3.49 K1
3-(8,9-Dihydroxyfarnesyl)indole 2.86 K1
Apocynaceae  Alstonia angustifolia Villalstonine (23) 0.18 K1
Peschiera fuchsiaefolia Voacamine (24) 0.29 W2
Picralima nitida Akuammine (25) 0.001 W2
Araceae Rhaphidophora decursiva Polysyphorin (26) 0.368 W2
Rhaphidecurperoxin (27) 0.42 W2
Asparagaceae Asparagus africanus Muzanzagenin (28) 7.07 Dd2
Nyasol (29) 3.02 Dd2
Asphodelaceae Kniphophia foliosa Knipholone (30) 0.46 K1
Bulbine capitata Anthrone 31 0.16 K1
Berberidaceae Berberis spp. Berbamine (32) 0.19
Berberine (33) 0.32 K1
Bignoniaceae Kigelia pinnata 2-(1-Hydroxyethyl)naphtha [2,3-b]furan-4,9-dione (36) 0.152 K1
Isopinnatal (37) 0.258 K1
Celastraceae Salacia kraussii 28-nor-Isoiguesterin-17-carbaldehyde (38) 0.094 K1
17-Methoxycarbonyl-28-nor-isoiguesterin (39) 0.027 K1
28-Hydroxyisoiguesterin (40) 0.114 K1
Celastrol (41) 0.18 K1
Celastrus paniculatus Pristimerin (42) 0.19 K1
Chenopodiaceae Chenopodium ambrosioides Isoiguesterol (43) 0.023 K1
Clusiaceae Garcinia dulcis Garciniaxanthone (45) 0.96
Cowanol (46) 1.6
Cowaxanthone (47) 1.5
Hypericum japonicum japonicin A (48)
japonicin B (49)
Hypericum calycinum Phloroglucinol derivative (50) 0.88 K1
Vismia guineensis Vismione H (51) 0.088 NF 54
Combretaceae Terminalia bellerica Termilignan (52) 2.85 3D7
Anolignan B (53) 5.32 3D7
Compositae Artemisia indica Exiguaflavone A (54) 4.6 K1
Exiguaflavone B (55) 7.05 K1
Artemisia abrotanum Isofraxidin (56) 7.95 K1
(1S)-1-Hydroxy-α-bisabololoxide A acetate (57) 5.09 K1
Asteraceae Eupatorium rufescens Zingiberene-3,6-β-endoperoxide (58) 10 FCH-5
Senecio selloi Zingiberene-3,6-α-endoperoxide (59) 10 FCH-5
Neurolaena lobata Neurolenin A (61) 0.336 NF 54
Neurolenin B (62) 0.263 NF 54
Vernonia brachycalyx 2’-Epicycloisobrachycoumarinone epoxide (64) 3D7
Cyclosiobrachycoumarinone epoxide (65) 3D7
16,17-Dihydrobrachycalyxolide (66) 13.7 3D7
Cyperaceae Cyperus rotundus α-Cyperone (68) 5.5 K1
β-Selinene (69) autoxidised 5.56 K1
10,12-Peroxycalamenene (70) K1
Dracaenaceae Dracaena mannii Spiroconazole A (71) 0.03 W2
Ebenaceae Diospyros montana Diospyrin (72) K1
Euphorbiaceae Phyllanthus fraternus E,E-2,4-Octadienamide (73) 3D7
E,Z,-2,4-Decadienamide (74) 3D7
Margaritaria discoidea Securinine (75) 5.4 K1
Fabaceae Andira inermis Andidermal A (76) 3.9 Dd2
Andidermal C (77) 6.3 Dd2
Calycosin (78) 9.8 Dd2
Genistein (79) 4.1 Dd2
Bauhinia malabarica Racemosol (80) 0.9 K1
Demethylracemosol (81) 2 K1
Hernandiaceae Hernandia voyronii Herveline A (83) 2.13 FCM29
Herveline B (84) 1.09 FCM29
Herveline C (85) 1.87 FCM29
Herveline D (86) 1.41 FCM29
Laudanosine (87) 9.53 FCM29
Sparattanthelium amazonum Roemrefidine (88) 0.21 20/87
Lamiaceae Hoslundia opposita 3-O-Benzoylhosloppone (89) 0.4 K1
Lauraceae  Nectandra salicifolia Costaricine (90) 0.05 W2
Malvaceae Gossypium spp. Gossypol (91)
Meliaceae Azadirachta indica Gedunin (92) 0.02 W2
Khaya senegalensis Fissinolide (95) 24.5 3D7
Candicusine (96) 0.06 W2
12-O-Methyltricordatine (97) 0.06 W2
Cycleapeltine (98) 0.04 W2
Cepharanthine (99) 0.29 W2
Cycleanine (100) 0.15 W2
Stephania venosa Dehydrodiscretine (101) 0.01
Menispermaceae Stephania venosa Dehydrostephanine (102) 0.04
Moraceae Artocarpus integer 1",2" dehydro Stilbene 103 1.7 K1
2",3" dehydro Stilbene 104 8.2 K1
Stilbene 105 9.4 K1
Nepenthaceae Nephenthes thorelii Plumbagin (109) T9/94
Olacaceae Minquartia guianensis Minquartynoic acid (110) 3 3D7
Periplocaceae Cryptolepis sanguinolenta Cryptolepine (111) 0.033 K1
11-Hydroxycryptolepine (112) 0.045 K1
Quindoline (113) 0.087 K1
Neocryptine (114) 0.051 K1
Ranunculaceae Thalictrum faberi Thalifasine (116) 0.049 W2
Isopyrum thalictroides Penduline (117) 0.01 W2
Cimicifuga spp. (26S)-O-Methylactein (118). 0.69 FCR3
Rubiaceae Psychotria camponutans Quinone 119 0.84 K1
Morinda lucida Damnacanthal (120). 9.2
Anthocephalus chinensi Cadambine (121) 3.68 K1
Pogonopus tubulosus Tubulosine (122) 0.011 INDO
Rutaceae Fagara rhetza Hazaleamide (123) 11.8
Toddalia asiatica Nitidine (125) 0.045 K39
5,7-Dimethoxy-8-(3’-hydroxy-3’methyl-1’-butene)coumarin 16.2 K39
N-Isobutyldeca-2,4-dienamide 5.37 K1
Fagaramide (126) 12.34 K1
Simaroubaceae Brucea javanica Bruceajavanin A (129) 0.62 K1
Dihydrobruceajavanin A (130) 1.42 K1
Bruceacanthinoside K1
Bruceine A (132) 0.011 K1
Bruceine B (133) 0.011 K1
Bruceine C (134) 0.005 K1
Bruceantin (135) 0.0008 K1
Bruceantinol (136) 0.002 K1
Dehydrobruceine A (137) 0.046 K1
Brusatol (138) 0.003 K1
Bruceine D (139) 0.015 K1
Yadanziolide A (140) 0.031 K1
Yadanzioside F (142) 5 K1
Yadanzioside I (143) 22.04 K1
Brucea sumatrana Bruceolide (144) 0.451 K1
Eurycoma longifolia Quassinoid 145 0.21 K1
Quassinoid 146 1.15 K1
Quassinoid 147 0.11 K1
Quassinoid 148 0.28 K1
Simaba guianensis Gutolactone (151) 0.004 W2
Simalikalactone D (152) 0.0016 W2
Simarouba amara Quassinoid 153 0.009 K1
Quassinoid 154 0.008 K1
Quassinoid 155 0.007 K1
Quassinoid 156 0.004 K1
Simana cedron Cedronin (157) 0.23 Fcc2
Solanaceae Saracha punctata Sarachine (158) 0.07 INDO
Strychnaceae Strychnos spp. Strychnobrasiline (159) 73.08
Malagashanine (160) 69.12
Strychnos usambarensis Dihydrousambarensine (161) 0.01 K1
Strychnopentamine (162) 0.09 K1
10’-Hydroxyusambarensine (163) 0.16 W2
Strychnos icaja Strychnogucine B (164) 0.41 FCA 20
Valerianaceae Nardostachys chinensis Nardosinone (166) 1.13
Nardoperoxide (167) 0.4
Diterpene peroxide 168 0.06
Zingiberaceae Reneilmia cincinnata Sesquiterpenoid 169 1.63 D-6
Sesquiterpenoid 170 1.64 D-6
Online articles related to Antimalarial activity of plant metabolites retrieved from PubMed