Malaria Parasite Metabolic Pathways
Drugs affecting pathway with unknown specific target
| Drug Name | PubMed Articles (year of publication) |
|---|---|
| 4H-dispiro[cyclohexane-1,3′-[1,2,4,5]tetroxane-6′,2′′-tricyclo[3.3.1.13,7]decan]-4-on | |
| Artemisinin | |
| Artesunate | |
| C-terminal peptide of pfclpy (fi peptide) | |
| Dihydroartemisinin | |
| dispiro[cyclohexane-1,3′-[1,2,4,5]tetroxane-6′,2′′-tricyclo[3.3.1.13,7]decan]-4-yl acetate | |
| Tetraoxane |
Transporters of the mitochondrial and apicoplast membranes map details
| PFID | PFID Old | Annotation | Formal Annotation | EC | Transcript |
|---|---|---|---|---|---|
PF3D7_1231400
|
PFL1515c | AAAP3 | membrane protein icm1 |
|
|
| PF3D7_1004800 | PF10_0051 | AAC1 | ADP, ATP carrier protein 2, aac2 |
|
|
PF3D7_1037300
|
PF10_0366 | AAC2 | ADP, ATP carrier protein 1, aac1 |
|
|
|
PF3D7_0727800
|
PF07_0115 | ATP10 | cation transporting ATPase, putative | 3.6.3.12 |
|
| PF3D7_0504000 | PFE0195w | ATP3 | cation transporting P-ATPase, ATPase3 | 3.6.3.14 |
|
| PF3D7_1223800 | PFL1145w | COC | citrate/oxoglutarate carrier protein, putative |
|
|
|
PF3D7_1421900
|
PF14_0211 | CTR2 | copper transporter, putative, CTR2 |
|
|
| PF3D7_0715800 | PF07_0064 | DMT1 | drug/metabolite transporter dmt1, putative, DMT1 |
|
|
|
PF3D7_0823900
|
PF08_0031 | DTC | dicarboxylate/tricarboxylate carrier, DTC |
|
|
|
PF3D7_0217100
|
PFB0795w | F-ATPase | ATP synthase subunit alpha, mitochondrial | 3.6.3.14 |
|
|
PF3D7_0705900
|
MAL7P1.340 | F-ATPase | ATP synthase subunit C, putative | 3.6.3.14 |
|
|
PF3D7_0715500
|
MAL7P1.75 | F-ATPase | ATP synthase subunit epsilon, mitochondrial, putative | 3.6.3.14 |
|
|
PF3D7_1147700
|
PF11_0485 | F-ATPase | ATP synthase subunit delta, mitochondrial, putative | 3.6.3.14 |
|
|
PF3D7_1235700
|
PFL1725w | F-ATPase | ATP synthase subunit beta, mitochondrial | 3.6.3.14 |
|
|
PF3D7_1310000
|
MAL13P1.47 | F-ATPase | ATP synthase subunit o, mitochondrial, putative | 3.6.3.14 |
|
|
PF3D7_1311300
|
PF13_0061 | F-ATPase | ATP synthase subunit gamma, mitochondrial | 3.6.3.14 |
|
|
PF3D7_0530200
|
PFE1510c | ipPT | phosphoenolpyruvate/phosphate translocator, PPT |
|
|
| PF3D7_0417300 | PFD0835c | LetM1 | LETM1-like protein, putative |
|
|
| PF3D7_0108400 | PFA0415c | MC1 | mitochondrial carrier protein, putative |
|
|
| PF3D7_0108800 | PFA0435w | MC1 | mitochondrial carrier protein, putative |
|
|
| PF3D7_0407500 | PFD0367w | MC1 | mitochondrial carrier protein, putative |
|
|
| PF3D7_0811100 | PF08_0093 | MC1 | mitochondrial carrier protein, putative |
|
|
| PF3D7_0905200 | PFI0255c | MC1 | mitochondrial carrier protein, putative |
|
|
| PF3D7_0908800 | PFI0425w | MC1 | mitochondrial carrier protein, putative |
|
|
|
PF3D7_0926400
|
PFI1295c | MCP2 | monocarboxylate transporter, putative |
|
|
| PF3D7_1145500 | PF11_0466 | MDR3 | ABC transporter B family member 3, putative. ABCB3 |
|
|
|
PF3D7_0302600
|
PFC0125w | MDR4 | ABC transporter B family member 4, putative, ABCB4 |
|
|
|
PF3D7_1352100
|
PF13_0271 | MDR6 | ABC transporter B family member 6, putative, ABCB6 |
|
|
|
PF3D7_1209900
|
PFL0495c | MDR7 | ABC transporter B family member 7, putative, ABCB7 |
|
|
|
PF3D7_1440800
|
PF14_0387 | MFS6 | major facilitator superfamily domain-containing protein, MFS6 |
|
|
| PF3D7_1340800 | PF13_0223 | MPC1,2 | mitochondrial pyruvate carrier protein 1, putative, MPC1 |
|
|
| PF3D7_1470400 | PF14_0671 | MPC1,2 | mitochondrial pyruvate carrier protein 2, putative, MPC2 |
|
|
| PF3D7_0209600 | PFB0435c | NSS1 | transporter, putative |
|
|
| PF3D7_0515500 | PFE0775c | NSS2,3 | gametogenesis essential protein 1, putative, gep1 |
|
|
| PF3D7_1132500 | PF11_0334 | NSS2,3 | amino acid transporter, putative |
|
|
| PF3D7_1432100 | PF14_0301 | OMPP, VDAC | voltage-dependent anion-selective channel protein, putative |
|
|
|
PF3D7_0508300
|
PFE0410w | opPT | triose phosphate transporter, TPT |
|
|
| PF3D7_1202200 | PFL0110c | PIC | mitochondrial phosphate carrier protein, MPC |
|
|
| PF3D7_1241600 | PFL2000w | SAMC | S-adenosylmethionine mitochondrial carrier protein, SAMC |
|
|
| PF3D7_1368700 | PF13_0359 | TPC | mitochondrial carrier protein, putative |
|
Total number of related proteins: 6
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFA0415c | mitochondrial carrier protein, putative |
| 2 | PFA0435w | mitochondrial carrier protein, putative |
| 3 | PFD0367w | mitochondrial carrier protein, putative |
| 4 | PF08_0093 | mitochondrial carrier protein, putative |
| 5 | PFI0255c | mitochondrial carrier protein, putative |
| 6 | PFI0425w | mitochondrial carrier protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFB0435c | transporter, putative |
Total number of related proteins: 7
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFB0795w
|
ATP synthase subunit alpha, mitochondrial |
| 2 |
MAL7P1.340
|
ATP synthase subunit C, putative |
| 3 |
MAL7P1.75
|
ATP synthase subunit epsilon, mitochondrial, putative |
| 4 |
PF11_0485
|
ATP synthase subunit delta, mitochondrial, putative |
| 5 |
PFL1725w
|
ATP synthase subunit beta, mitochondrial |
| 6 |
MAL13P1.47
|
ATP synthase subunit o, mitochondrial, putative |
| 7 |
PF13_0061
|
ATP synthase subunit gamma, mitochondrial |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFC0125w
|
ABC transporter B family member 4, putative, ABCB4 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFD0835c | LETM1-like protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFE0195w | cation transporting P-ATPase, ATPase3 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFE0410w
|
triose phosphate transporter, TPT |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFE0775c | gametogenesis essential protein 1, putative, gep1 |
| 2 | PF11_0334 | amino acid transporter, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFE1510c
|
phosphoenolpyruvate/phosphate translocator, PPT |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF07_0064 | drug/metabolite transporter dmt1, putative, DMT1 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF07_0115
|
cation transporting ATPase, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF08_0031
|
dicarboxylate/tricarboxylate carrier, DTC |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFI1295c
|
monocarboxylate transporter, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF10_0051 | ADP, ATP carrier protein 2, aac2 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF10_0366
|
ADP, ATP carrier protein 1, aac1 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF11_0466 | ABC transporter B family member 3, putative. ABCB3 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL0110c | mitochondrial phosphate carrier protein, MPC |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFL0495c
|
ABC transporter B family member 7, putative, ABCB7 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL1145w | citrate/oxoglutarate carrier protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PFL1515c
|
membrane protein icm1 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PFL2000w | S-adenosylmethionine mitochondrial carrier protein, SAMC |
Total number of related proteins: 2
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF13_0223 | mitochondrial pyruvate carrier protein 1, putative, MPC1 |
| 2 | PF14_0671 | mitochondrial pyruvate carrier protein 2, putative, MPC2 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF13_0271
|
ABC transporter B family member 6, putative, ABCB6 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF13_0359 | mitochondrial carrier protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF14_0211
|
copper transporter, putative, CTR2 |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 | PF14_0301 | voltage-dependent anion-selective channel protein, putative |
Total number of related proteins: 1
| # | PFID | Formal Name |
|---|---|---|
| 1 |
PF14_0387
|
major facilitator superfamily domain-containing protein, MFS6 |