Phosphoproteome
Data were collected from 5 different publications. Each publication is collor-coded and on the right side are indicated the articles in which a specific gene product is present - the more sources, the more reliable is the finding. The table geenrated from
Collins MO, Wright JC, Jones M, Rayner JC, Choudhary JS. Confident and sensitive phosphoproteomics using combinations of collision induced dissociation and electron transfer dissociation. J Proteomics. 2014 103C:1-14. PMID: 24657495
http://mpmp.huji.ac.il/maps/phosph_collins.html
Lasonder E, Green JL, Camarda G, Talabani H, Holder AA, Langsley G, Alano P. The Plasmodium falciparum schizont phosphoproteome reveals extensive phosphatidylinositol and cAMP-protein kinase A signaling. J Proteome Res. 2012 11(11):5323-37. PMID: 23025827
http://mpmp.huji.ac.il/maps/phosph_lasonder.html
Treeck M, Sanders JL, Elias JE, Boothroyd JC. The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries. Cell Host Microbe. 2011 10(4):410-9. PMID: 22018241
http://mpmp.huji.ac.il/maps/phosph_treeck.html
Pease BN, Huttlin EL, Jedrychowski MP, Talevich E, Harmon J, Dillman T, Kannan N, Doerig C, Chakrabarti R, Gygi SP, Chakrabarti D. Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic develop
http://mpmp.huji.ac.il/maps/phosph_pease.html
Solyakov L, Halbert J, Alam MM, Semblat JP, Dorin-Semblat D, Reininger L, Bottrill AR, Mistry S, Abdi A, Fennell C, Holland Z, Demarta C, Bouza Y, Sicard et al. Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falcipa
http://mpmp.huji.ac.il/maps/phosphopr.html
Wu Y, Nelson MM, Quaile A, Xia D, Wastling JM, Craig A. Identification of phosphorylated proteins in erythrocytes infected by the human malaria parasite Plasmodium falciparum. Malar J. 2009 May 18;8:105 PMID: 19450262;
Category PfID Annotation EC Transcript
Amino acid metabolism PF08_0132
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glutamate dehydrogenase, putative 1.4.1.2
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PF10_0322
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S-adenosylmethionine decarboxylase/ornithine decarboxylase (AdoMetDC/ODC) 4.1.1.17
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PF11_0301
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spermidine synthase (SpdSyn) 2.5.1.16
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PF11_0311 N-acetyl glucosamine phosphate mutase, putative 5.4.2.3
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PF14_0286
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NADP-specifiglutamate dehydrogenase 1.4.1.4
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PF14_0334
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NAD(P)H-dependent glutamate synthase 1.4.1.14
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PFB0200c
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aspartate aminotransferase 2.6.1.1
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PFC0395w asparagine synthetase, putative 6.3.5.4
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PFD0285c
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lysine decarboxylase, putative 4.1.1.18
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PFD0670c lysine decarboxylase-like protein, putative 4.1.1.18
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PFE1050w
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S-adenosyl-L-homocysteine hydrolase (SAHH) 3.3.1.1
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PFF0435w
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ornithine aminotransferase (OAT) 2.6.1.13
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PFI1090w
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S-adenosylmethionine synthetase 2.5.1.6
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PFL1940w 3-hydroxyisobutyryl-coenzyme A hydrolase, putative 3.1.2.4
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Carbohydrate metabolism MAL8P1.156
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mannose-6-phosphate isomerase, putative 5.3.1.8
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PF10_0122 phosphoglucomutase, putative 5.4.2.2
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PF10_0155
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enolase (ENO) 4.2.1.11
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PF11_0208
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phosphoglycerate mutase, putative (PGM1) 5.4.2.11
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PF13_0141
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L-lactate dehydrogenase 1.1.1.27
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PF14_0246
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phosphoenolpyruvate carboxylase, putative (PEPC) 4.1.1.31
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PF14_0341 glucose-6-phosphate isomerase 5.3.1.9
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PF14_0378
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triosephosphate isomerase 5.3.1.1
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PF14_0425
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fructose-bisphosphate aldolase 4.1.2.13
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PF14_0511
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glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (G6PDH) 1.1.1.49
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PF14_0520
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6-phosphogluconate dehydrogenase, decarboxylating, putative 1.1.1.44
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PF14_0598
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glyceraldehyde-3-phosphate dehydrogenase (GAPDH) 1.2.1.12
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PF14_0681 diacylglycerol kinase, putative 2.7.1.107
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PFC0430w phosphoglycerate mutase, putative 5.4.2.11
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PFC0525c
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glycogen synthase kinase 3 2.7.11.26
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PFF0895w
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malate dehydrogenase 1.1.1.37
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PFF1155w
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hexokinase 2.7.1.1
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PFF1300w
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pyruvate kinase 2.7.1.40
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PFI0755c
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6-phosphofructokinase (PFK9) 2.7.1.11
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PFI1105w
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phosphoglycerate kinase (PGK) 2.7.2.3
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PF11_0294 ATP-dependent 6-phosphofructokinase 2.7.1.11
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Cofactor metabolism
PFL1155w
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GTP cyclohydrolase I (GTP-CH) 3.5.4.16
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MAL13P1.292 riboflavin kinase / FAD synthase family protein, putative 2.7.1.26
PF08_0095
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dihydropteroate synthetase (DHPS) 2.5.1.15
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PF13_0140
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dihydrofolate synthase/folylpolyglutamate synthase (DHFS-FPGS) 6.3.2.12
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PF13_0159
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nicotinate-nucleotide adenylyltransferase, putative 2.7.7.18
PF13_0353
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NADH-cytochrome B5 reductase, putative 1.6.2.2
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PF14_0282 acid phosphatase, putative 3.1.3.2
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PF14_0354
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pantothenate kinase, putative 2.7.1.33
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PFF0775w
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pyridoxine kinase 2.7.1.35
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PFF1025c
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pyridoxine biosynthesis protein PDX1 (PDX1)
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PFF1335c
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4-methyl-5(B-hydroxyethyl)-thiazol monophosphate biosynthesis enzyme
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PF14_0664
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acetyl-coa carboxylase 6.3.4.14
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PFF1410c
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nicotinate phosphoribosyltransferase, putative 6.3.4.21
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Lipid metabolism PF07_0129 acyl-coA synthetase 6.2.1.3
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MAL13P1.485 acyl-CoA synthetase, PfACS4 6.2.1.3
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PF11_0483
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protein farnesyltransferase subunit beta 2.5.1.58
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PFL0620c
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glycerol-3-phosphate acyltransferase 2.3.1.15
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PFI0980w long chain fatty acid elongation enzyme, putative 6.2.1.3
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PF14_0738 lysophospholipase, putative 3.1.1.5
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PFF1210w
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sphingomyelin synthase 1, putative 2.7.8.27
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MAL7P1.108 phosphoinositide-binding protein, putative
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PFI1125c
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3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100
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PFF1350c acetyl-CoA synthetase, putative 6.2.1.1
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PF08_0099 acyl-CoA binding protein, putative
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PFB0695c
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acyl-CoA synthetase 6.2.1.3
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PFE1250w acyl-CoA synthetase 6.2.1.3
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PFL0035c acyl-CoA synthetase 6.2.1.3
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PFF0945c acyl-CoA synthetase (ACS12) 6.2.1.3
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PFL1880w acyl-CoA synthetase, PfACS11 6.2.1.3
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PF11_0197 acyl-CoA-binding protein, putative
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PF10_0020
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alpha/beta hydrolase, putative 3.1.1.23
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PFF1375c
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choline/ethanolaminephosphotransferase, putative (CEPT) 2.7.8.1
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MAL13P1.86
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choline-phosphate cytidylyltransferase (CCT) 2.7.7.15
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PF14_0097
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cytidine diphosphate-diacylglycerol synthase (CDS) 2.7.7.41
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PFI1485c diacylglycerol kinase, putative (DGK1) 2.7.1.107
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PF11_0257
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ethanolamine kinase, putative 2.7.1.82
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PF13_0253
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ethanolamine-phosphate cytidylyltransferase, putative (ECT) 2.7.7.14
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MAL13P1.348 glycosylphosphatidylinositol anchor attachment 1 protein, putative
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PFC0150w HAD superfamily protein, putative 3.1.3.4
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PFI1020c
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inosine-5'-monophosphate dehydrogenase 1.1.1.205
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MAL8P1.152 inositol phosphatase, putative
PF13_0089 inositol polyphosphate kinase, putative 2.7.1.151
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PF07_0024
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inositol-phosphate phosphatase, putative 3.1.3.25
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PFF0290w long chain polyunsaturated fatty acid elongation enzyme, putative 6.2.1.3
PF07_0040
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lysophospholipase, putative 3.1.-.-
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PF07_0042 lysophospholipase, putative
PFE0585c
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myo-inositol 1-phosphate synthase, putative 5.5.1.4
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PFF0915w N-acetylglucosamine transferase (GPI1) 2.4.1.198
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PF11_0252 neutral-sphingomyelinase activation factor protein, putative
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PF11_0327 oxysterol-binding protein-related protein 2
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PFC0475c phosphatidylinositol 3- and 4-kinase, putative 2.7.1.67
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PFE0765w
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phosphatidylinositol 3-kinase 2.7.1.137
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PFE0485w
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phosphatidylinositol 4-kinase 2.7.1.67
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PFD0965w phosphatidylinositol 4-kinase, putative 2.7.1.67
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PFD0965w phosphatidylinositol 4-kinase, putative 2.7.1.67
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PF11_0425 phosphatidylinositol N-acetylglucosaminyltransferase subunit H, putative 2.4.1.198
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MAL13P1.256 phosphatidylinositol transfer protein, putative
PFA0515w
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phosphatidylinositol-4-phosphate 5-kinase (PIP5K) 2.7.1.68
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MAL13P1.214
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phosphoethanolamine N-methyltransferase (PMT) 2.1.1.103
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MAL7P1.109 phosphoinositide-binding protein, putative
PF07_0017 phosphoinositide-binding protein, putative
MAL7P1.112 phosphoinositide-binding protein, putative
PF10_0132
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phosphoinositide-specific phospholipase C 3.1.4.11
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PFB0410c
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phospholipase A2, putative 3.1.1.4
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MAL8P1.91 Phospholipase DDHD1 3.1.1.32
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PFF1280w Sec14 domain containing protein
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PFL1870c
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sphingomyelin phosphodiesterase 3.1.4.12
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PF14_0403
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geranylgeranyl transferase type-2 subunit alpha 2.5.1.60
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Mucleotide metabolism PFL1890c HD superfamily phosphohydrolase protein 3.1.4.17
MAL13P1.118
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3',5'-cyclic nucleotide phosphodiesterase, putative (PDEbeta) 3.1.4.17
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MAL8P1.150
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adenylyl cyclase beta, putative (ACbeta) 4.6.1.1
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PF10_0086
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adenylate kinase 2.7.4.3
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PF10_0121
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hypoxanthine-guanine phosphoribosyltransferase (HGPRT) 2.4.2.8
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PF10_0289
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adenosine deaminase, putative 3.5.4.4
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PF11_0395 guanylyl cyclase 4.6.1.2
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PF13_0044
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carbamoyl phosphate synthetase (cpsSII) 6.3.5.5
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PF13_0143
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phosphoribosylpyrophosphate synthetase 2.7.6.1
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PF13_0273 P-loop containing nucleoside triphosphate hydrolase, putative
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PF13_0349
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nucleoside diphosphate kinase 2.7.4.6
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PF14_0100
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cytidine triphosphate synthetase 6.3.4.2
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PF14_0352
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ribonucleoside-diphosphate reductase, large subunit 1.17.4.1
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PFA0160c
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nucleoside transporter, putative
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PFB0295w
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adenylosuccinate lyase 4.3.2.2
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PFF0745c ribonuclease, putative 3.1.13.1
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PFL0475w
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cGMP-specific phosphodiesterase (PDE1) 3.1.4.35
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Redox metabolism PF14_0368
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thioredoxin peroxidase 1 1.11.1.15
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MAL13P1.159
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thioredoxin, putative
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PF10_0268
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peroxiredoxin 1.11.1.15
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PF14_0192
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glutathione reductase 1.8.1.7
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PFI0925w
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gamma-glutamylcysteine synthetase (gammaGCS) 6.3.2.2
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PFI1140w
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flavodoxin-like protein 1.14.13.39
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Hemoglobin digestion MAL13P1.56
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M1-family alanyl aminopeptidase (M1AAP) 3.4.11.2
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PF13_0322
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falcilysin 3.4.24.-
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PF14_0076
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plasmepsin I 3.4.23.38
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PF14_0077
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plasmepsin II 3.4.23.39
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PF14_0077
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plasmepsin II 3.4.23.39
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PF14_0078
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plasmepsin III,histo-aspartic protease (HAP) 3.4.23.-
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PF14_0553
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cysteine proteinase falcipain 1 3.4.22.-
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PFI0580c
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falstatin (ICP)
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MAL13P1.233
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DNA/RNA-binding protein Alba 2 (ALBA2)
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Mitosis and chromosome separation PF08_0117 AAA family ATPase, putative
PFD0390c
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AAA family ATPase, putative
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PF14_0443
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centrin-2
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PF11_0066
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centrin-4
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PF14_0173 cyclic nucleotide-binding protein, putative
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PFD1045c erythrocyte membrane-associated antigen, putative
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PFD0720w
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armadillo-domain containing rhoptry protein
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PF11_0397 beta-catenin-like protein 1, putative
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PFA0510w bromodomain protein, putative
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PF10_0271
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centrin-3
PF13_0149
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chromatin assembly factor 1 subunit, putative
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PF11_0053 chromatin remodeling protein
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PFE0090w
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chromosome assembly factor 1