Predicted potential drug targets using the PMH plus metabolic network
Afolabi R, Chinedu S, Ajamma Y, Adam Y, Koenig R, Adebiyi E. Computational identification of Plasmodium falciparum RNA pseudouridylate synthase as a viable drug target, its physicochemical properties, 3D structure prediction and prediction of potential inhibitors. Infect Genet Evol. 2022 97:105194.  PMID: 34968763.
PfID Protein targets EC number Transcript
PF3D7_0605600
nucleoside diphosphate kinase, putative 2.7.4.6
PF3D7_0910400 selenide water dikinase, putative 2.7.9.3
PF3D7_1414600 mRNA-capping enzyme subunit alpha 2.7.7.50
PF3D7_0219500
pseudouridine synthase, putative 4.2.1.70
PF3D7_1227900
RNA pseudouridylate synthase, putative 4.2.1.70
PF3D7_0914000 pseudouridylate synthase, putative 4.2.1.70
PF3D7_0628000 6-pyruvoyltetrahydropterin synthase 4.2.3.12
PF3D7_1332600
DNA-(apurinic or apyrimidinic site) lyase 1 4.2.99.18
PF3D7_0305600
AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 4.2.99.18
PF3D7_0917100 N-glycosylase/DNA lyase, putative 3.2.2.-
PF3D7_0614800 endonuclease III homologue, putative 4.2.99.18
PF3D7_1364900
ferrochelatase, HemH 4.99.1.1
PF3D7_1005000
methionine--tRNA ligase, putative 6.1.1.10
PF3D7_1442300
tRNA import protein tRIP
PF3D7_1251700
tryptophanyl-tRNA synthetase, putative tryptophan--tRNA ligase, putative 6.1.1.2
PF3D7_1232000
phenylalanine--tRNA ligase 6.1.1.20
PF3D7_0211800 asparagine--tRNA ligase 6.1.1.22
PF3D7_0509600
asparagine--tRNA ligase 6.1.1.22
PF3D7_0514300 aspartate--tRNA ligase, putative 6.1.1.12
PF3D7_1350100
lysine--tRNA ligase 6.1.1.6
PF3D7_0215300
acyl-CoA synthetase 6.2.1.3
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