Peptidases and proteases
Weißbach T, Golzmann A, Bennink S, Pradel G, Julius Ngwa C. Transcript and protein expression analysis of proteases in the blood stages of Plasmodium falciparum. Exp Parasitol. 2017 180:33-44. PMID: 28351685.
Data for MEROPS were taken from  (http://merops.sanger.ac.uk/index.htm) with additions. Clans and families are linked to MEROPS.
PfID Annotation EC Transcript MEROPS assignment
Cysteine proteases Clan Family MEROPS ID
PF3D7_1458000
cysteine proteinase falcipain 1 3.4.22.-
AA A1 A01.022
PF3D7_1115700
cysteine proteinase falcipain 2a falcipain 2 3.4.22.-
AA A1 A01.023
PF3D7_1115300
falcipain 2' cysteine proteinase falcipain 2b 3.4.22.-
AA A1 A01.043
PF3D7_1115400
cysteine proteinase falcipain 3 3.4.22.-
AA A1 A01.058
PF3D7_1116700
dipeptidyl aminopeptidase 1 cathepsin C, homolog 3.4.14.1
AA A1 A01.058
PF3D7_1247800
dipeptidyl aminopeptidase 2 3.4.14.1
AA A1 A01.059
PF3D7_0404700
dipeptidyl aminopeptidase 3 3.4.14.4
AA A1 A01.075
PF3D7_0208000
serine repeat antigen 1 3.4.22.-
AA A1 A01.A32
PF3D7_0207900 serine repeat antigen 2 3.4.22.-
AA A1 A01.A93
PF3D7_0207800
serine repeat antigen 3 3.4.22.-
AA A1 A01.A95
PF3D7_0207700
serine repeat antigen 4 3.4.22.-
AA A1 unassigned
PF3D7_0207600
serine repeat antigen 5 3.4.22.-
AA A28 A28.A07
PF3D7_0207500
serine repeat antigen 6 3.4.22.-
AD A22 A22.013
PF3D7_0207400
serine repeat antigen 7 3.4.22.-
CA C1 C01.046
PF3D7_0207300 serine repeat antigen 8 3.4.22.-
CA C1 C01.063
PF3D7_0902800
serine repeat antigen 9 3.4.22.2
CA C1 C01.077
PF3D7_1362400
calpain 3.4.22.-
CA C1 C01.124
PF3D7_1117100 ubiquitin carboxyl-terminal hydrolase uch54 3.4.19.12
CA C1 C01.126
PF3D7_0104300
ubiquitin carboxyl-terminal hydrolase 1, putative 3.4.19.12
CA C1 C01.169
PF3D7_0403500 ubiquitin specific protease, putative 3.1.2.15
CA C1 C01.984
PF3D7_0413900 ubiquitin carboxyl-terminal hydrolase 13, putative 3.4.19.12
CA C1 C01.984
PF3D7_0527200
ubiquitin carboxyl-terminal hydrolase 14 3.4.19.12
CA C1 C01.984
PF3D7_0516700 ubiquitin carboxyl-terminal hydrolase 2, putative 3.4.19.12
CA C1 C01.984
PF3D7_0726500 ubiquitin carboxyl-terminal hydrolase, putative 3.4.19.12
CA C1 C01.984
PF3D7_0904600 ubiquitin specific protease, putative 3.4.19.12
CA C1 C01.984
PF3D7_1317000 U4/U6.U5 tri-snRNP-associated protein 2, putative
CA C1 C01.A64
PF3D7_1414700 ubiquitin carboxyl-terminal hydrolase, putative 3.4.19.12
CA C1 non-peptidase homologue
PF3D7_1128700 GPI-anchor transamidase 3.4.13.19
CA C1 non-peptidase homologue
PF3D7_1354800
metacaspase 1 3.4.22.-
CA C1 non-peptidase homologue
PF3D7_1438400
metacaspase-2
CA C1 unassigned
PF3D7_1233900 sentrin-specific protease 1 3.4.22.68 CA C1 unassigned
PF3D7_0801700 sentrin-specific protease 2, putative 5.3.1.8
CA C2 C02.029
PF3D7_0627500
protein DJ-1
CA C12 C12.010
PF3D7_0309500 asparagine synthetase [glutamine-hydrolyzing], putative 6.3.5.4
CA C12 C12.A12
PF3D7_0809600 peptidase family C50, putative separase, putative 3.4.22.49
CA C19 C19.A74
PF3D7_0919200 PPPDE peptidase, putative
CA C19 C19.A75
PF3D7_0922400
para-aminobenzoic acid synthetase 2.6.1.85
CA C19 C19.A76
PF3D7_1006900 PPPDE peptidase, putative
CA C19 C19.A77
PF3D7_1012600
GMP synthase [glutamine-hydrolyzing] 6.3.5.2
CA C19 C19.A78
PF3D7_1025100 glutamine--fructose-6-phosphate aminotransferase [isomerizing], putative 2.6.1.16
CA C19 C19.A79
PF3D7_1031400
OTU-like cysteine protease 3.4.22.-
CA C19 C19.A80
PF3D7_1111900 Josephin domain-containing protein, putative 3.4.19.12
MA M3 unassigned
PF3D7_1116200
pyridoxine biosynthesis protein PDX2 1.4.3.5
MA M100 M100.UPW
PF3D7_1217900 PPPDE peptidase domain-containing protein, putative MA M41 M41.A13
PF3D7_1226800 ataxin-3, putative 3.4.19.12
MA M41 M41.A21
PF3D7_1308200
carbamoyl phosphate synthetase 6.3.5.5
MA M41 unassigned
PF3D7_1410200
CTP synthase 6.3.4.2
MA M76 M76.A01
PF3D7_1460400
ubiquitin carboxyl-terminal hydrolase isozyme L3 3.4.19.12
MA M80 unassigned
Aspartic proteases
PF3D7_1407900
plasmepsin I 3.4.23.38
AA A1 A01.022
PF3D7_1408000
plasmepsin II 3.4.23.39
AA A1 A01.023
PF3D7_1408100
plasmepsin III histo-aspartic protease 3.4.23.-
AA A1 A01.023
PF3D7_1407800
plasmepsin IV 3.4.23.-
NA
PF3D7_1323500
PEXEL protease plasmepsin V 3.4.23.-
AA A1 A01.075
PF3D7_0311700
plasmepsin VI 3.4.23.-
AA A1 A01.058
PF3D7_1033800
plasmepsin VII 3.4.23.-
AA A1 A01.A32
PF3D7_1465700
plasmepsin viii, putative 3.4.17.4
AA A1 A01.058
PF3D7_1430200
plasmepsin IX 3.4.23.-
AA A1 A01.A32
PF3D7_0808200
plasmepsin X 3.4.23.1
NA
PF3D7_1234400
microgamete surface protein migs, putative
PF3D7_1409300
DNA damage-inducible protein 1 3.4.23.-
AA A28 A28.A07
PF3D7_1457000
signal peptide peptidase 3.4.21.89
AD A22 A22.013
Serine proteases
PF3D7_0807700
serine protease DegP 3.4.21.-
PA S1 S01.B87
PF3D7_0321500 peptidase, putative 3.4.21.26
SC S9 S09.A66
PF3D7_0307400
ATP-dependent Clp protease proteolytic subunit 3.4.21.92
SK S14 S14.011
PF3D7_1436800 ATP-dependent Clp protease proteolytic subunit 3.4.21.92
SK S14 non-peptidase homologue
PF3D7_0816600
chaperone protein ClpB1
NA
PF3D7_1406600
ATP-dependent Clp protease regulatory subunit Clpc, putative 3.4.21.92
NA
PF3D7_1116800
heat shock protein 101 chaperone protein ClpB2
NA
PF3D7_1414900
ATP-dependent protease, putative 3.4.21.53
SJ S16 S16.A14
PF3D7_1320400 type I signal peptidase 3.4.21.89
SF S26 non-peptidase homologue
PF3D7_1331300
signal peptidase complex catalytic subunit SEC11 3.4.21.89
SF S26 S26.010
PF3D7_0507500
subtilisin-like protease 1 3.4.21.62
SB S8 S08.013
PF3D7_1136900
subtilisin-like protease 2 3.4.21.62
SB S8 S08.013
PF3D7_0507200
subtilisin-like protease 3 3.4.21.62
SB S8 non-peptidase homologue
PF3D7_1114100
rhomboid protease ROM1 3.4.21.105
ST S54 S54.018
PF3D7_0828000 rhomboid protease ROM3 3.4.21.105
ST S54 S54.021
PF3D7_0506900
rhomboid protease ROM4 3.4.21.105
ST S54 S54.017
PF3D7_1345200 rhomboid protease ROM6, putative 3.4.21.105
ST S54 unassigned
PF3D7_1358300
rhomboid protease ROM7 3.4.21.105
ST S54 unassigned
PF3D7_1411200 rhomboid protease ROM8 3.4.21.105
ST S54 S54.A13
PF3D7_0515100 rhomboid protease ROM9 3.4.21.105
ST S54 unassigned
PF3D7_0618600 rhomboid protease ROM10 3.4.21.105 ST S54 non-peptidase homologue
PF3D7_0826200 alpha/beta hydrolase, putative
SC S33 S33.B16
PF3D7_0812200 trypsin-like serine protease, putative
NA
PF3D7_0805000 alpha/beta hydrolase, putative
NA
PF3D7_0812220
GTP-binding protein YihA3
NA
PF3D7_1032500 DER1-like protein, putative
ST S54 non-peptidase homologue
PF3D7_1401300
proline aminopeptidase 3.4.11.5
SC S33 unassigned
PF3D7_1410100
alpha/beta hydrolase, putative
NA
PF3D7_1468500 derlin-1
ST S54 non-peptidase homologue
PF3D7_1001400
exported lipase 1 3.1.1.5
SC S33 S33.B17
PF3D7_0731800 alpha/beta hydrolase, putative gametocyte exported protein 8 SC S33 S33.B17
PF3D7_0403800 alpha/beta hydrolase, putative
SC S9 S09.A95
PF3D7_0301300
epoxide hydrolase 1
SC S33 unassigned
Threonine proteases
PF3D7_1474800 proteasome subunit alpha type-1, putative 3.4.25.1
PB T1 T01.A16
PF3D7_0608500 proteasome subunit alpha type-2, putative 3.4.25.1
PB T1 T01.972
PF3D7_0317000 proteasome subunit alpha type-3, putative 3.4.25.1
PB T1 unassigned
PF3D7_1353800 proteasome subunit alpha type-4, putative 3.4.25.1
PB T1 T01.973
PF3D7_0727400
proteasome subunit alpha type-5, putative 3.4.25.1
PB T1 unassigned
PF3D7_0807500 proteasome subunit alpha type-6, putative 3.4.25.1
PB T1 unassigned
PF3D7_1353900 proteasome subunit alpha type-7, putative 3.4.25.1
PB T1 T01.974
PF3D7_0518300
proteasome subunit beta type-1, putative 3.4.25.1
PB T1 T01.A14
PF3D7_0803800
proteasome subunit beta type-4 3.4.25.1
PB T1 unassigned
PF3D7_0108000
proteasome subunit beta type-3, putative 3.4.25.1
NA
PF3D7_1470900
proteasome subunit beta type-2, putative 3.4.25.1
PB T1 unassigned
PF3D7_0931800
proteasome subunit beta type-6, putative 3.4.25.1
PB T1 T01.010
PF3D7_1328100 proteasome subunit beta type-7, putative 3.4.25.1
PB T1 T01.A02
PF3D7_1011400
proteasome subunit beta type-5 3.4.25.1
PB T1 T01.A15
PF3D7_1230400
ATP-dependent protease subunit ClpQ 3.5.1.98
PB T1 T01.018
Metalloproteases
PF3D7_1311800
M1-family alanyl aminopeptidase 3.4.11.2
MA M1 M01.029
PF3D7_1005700 peptidase
MA M3 M03.A11
PF3D7_1337000 mitochondrial intermediate peptidase, putative 3.4.24.59
MA M3 unassigned
PF3D7_0523100 cytochrome b-c1 complex subunit 2, putative 3.4.24.64
ME M16 non-peptidase homologue
PF3D7_0933600
cytochrome b-c1 complex subunit 1, putative 3.4.24.64
ME M16 M16.003
PF3D7_1118300 insulinase, putative 3.4.24.56
ME M16 M16.A22
PF3D7_1121800
peptidase m16, putative 3.4.24.55
ME M16 non-peptidase homologue
PF3D7_1360800
falcilysin 3.4.24.-
ME M16 M16.011
PF3D7_1440200
stromal-processing peptidase, putative 3.4.24.56
ME M16 M16.A21
PF3D7_1446200
M17 leucyl aminopeptidase 3.4.11.1
MF M17 M17.008
PF3D7_0932300
M18 aspartyl aminopeptidase 3.4.11.21
MH M18 M18.003
PF3D7_1030600
tRNA N6-adenosine threonylcarbamoyltransferase 2.3.1.234
NA
PF3D7_0804400
methionine aminopeptidase 1c, putative 3.4.11.18
MG M24 M24.A13
PF3D7_1015300
methionine aminopeptidase 1b, putative 3.4.11.18
MG M24 M24.001
PF3D7_1434600
methionine aminopeptidase 2 3.4.11.18
MG M24 unassigned
PF3D7_1454400
aminopeptidase P 3.4.11.9
MG M24 M24.038
PF3D7_1239700
ATP-dependent zinc metalloprotease FTSH 1 3.4.24.-
MA M41 unassigned
PF3D7_1464900 ATP-dependent zinc metalloprotease FTSH, putative 3.4.24.-
MA M41 M41.A21
PF3D7_1119600
ATP-dependent zinc metalloprotease FTSH, putative 3.4.24.-
MA M41 M41.A13
PF3D7_0103400 zinc-carboxypeptidase, putative 3.4.17.10
MC M14 M14.A35
PF3D7_0517400 FACT complex subunit SPT16, putative MG M24 non-peptidase homologue
PF3D7_0527300 methionine aminopeptidase 1a, putative 3.4.11.18
MG M24 M24.001
PF3D7_0912900 26S proteasome regulatory subunit RPN8, putative
MP M67 M67.973
PF3D7_0913500
apicoplast-minus ipp-rescued 4
G- G5 G05.A10
PF3D7_0918300 eukaryotic translation initiation factor 3 subunit F, putative
MP M67 non-peptidase homologue
PF3D7_1005600 DnaJ protein, putative
NA
PF3D7_1009500 metalloprotease 3.4.24.-
MA M80 unassigned
PF3D7_1305600 site-2 protease s2p, putative
MM M50 M50.A09
PF3D7_1368100 26S proteasome regulatory subunit RPN11, putative
MP M67 M67.001
PF3D7_1428300 proliferation-associated protein 2g4, putative
MG M24 non-peptidase homologue
PF3D7_1441700
mitochondrial inner membrane protease atp23, putative
MA M76 M76.A01
PF3D7_1472400
M1-family alanyl aminopeptidase, putative 3.4.11.2
MA M1 non-peptidase homologue
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