Drug-target associations predicted for P. falciparum
Ramakrishnan G, Chandra N, Srinivasan N. Exploring anti-malarial potential of FDA approved drugs: an in silico approach. Malar J. 2017 16(1):290. PMID: 28720135
Highlighted entries in pink denote drug-target associations that require critical evaluation; green denote proteins localized in apicoplast
Entries in italics correspond to associations concurring with a previously published study (Bispo et al. 2013)
FDA-approved drugs which are already known to be anti-malarial, though independently predicted in the current analysis, are not listed in this Table
PfID Annotation Sporozoite Ring Trophozoite Schizont Merozoite Gametocyte Functional category Drug name
PF3D7_0203900
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5'-3' exonuclease, N-terminal resolvase-like domain, putative N N Y Y N N DNA-dependent processes Azelaic Acid
PF3D7_0215700 DNA-directed RNA polymerase II second largest subunit, putative Y Y Y Y Y Y DNA-dependent processes Rifabutin, Rifampicin, Rifaximin
PF3D7_0318200 DNA-directed RNA polymerase II subunit RPB1, putative (RPB1) Y Y Y Y Y Y DNA-dependent processes Rifabutin, Rifampicin
PF3D7_0411900 DNA polymerase alpha N N Y Y N Y DNA-dependent processes Vidarabine, Penciclovir, Famciclovir, Foscarnet, Valaciclovir, Aciclovir, Ganciclovir, Cidofovir, Foscarnet, Famciclovir, Aciclovir
PF3D7_0509400
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RNA polymerase I N Y Y N Y N DNA-dependent processes Rifabutin, Rifampicin
PF3D7_0625300
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DNA polymerase 1, putative N N Y Y N Y DNA-dependent processes Azelaic Acid
PF3D7_1017000
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DNA polymerase delta catalytic subunit Y Y Y Y Y Y DNA-dependent processes Vidarabine, Famciclovir, Aciclovir, Cidofovir, Foscarnet, Penciclovir, Valaciclovir, Ganciclovir
PF3D7_1037000 DNA polymerase zeta catalytic subunit, putative N N Y N Y Y DNA-dependent processes Vidarabine, Famciclovir, Aciclovir, Cidofovir, Foscarnet, Penciclovir, Valaciclovir, Ganciclovir
PF3D7_1134700 DNA-directed RNA polymerase I subunit RPA2, putative N Y Y N Y N DNA-dependent processes Rifabutin, Rifampicin, Rifaximin
PF3D7_1206600 DNA-directed RNA polymerase III subunit, putative Y Y Y N Y Y DNA-dependent processes Rifabutin, Rifampicin, Rifaximin
PF3D7_1223300
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DNA gyrase subunit A (GyrA) Y Y Y Y Y Y DNA-dependent processes Moxifloxacin, Enoxacin, Pefloxacin, Ciprofloxacin, Lomefloxacin, Norfloxacin, Levofloxacin, Gemifloxacin, Ofloxacin, Sparfloxacin, Fleroxacin, Besifloxacin, Rosoxacin, Gatifloxacin, Besifloxacin
PF3D7_1239500
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DNA gyrase subunit B (GyrB) Y N Y Y Y Y DNA-dependent processes Novobiocin, Rosoxacin, Ciprofloxacin
PF3D7_1307600
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DNA-directed RNA polymerase alpha chain, putative Y Y Y Y Y N DNA-dependent processes Rifabutin
PF3D7_1329000 DNA-directed RNA polymerase 3 largest subunit N Y Y Y Y Y DNA-dependent processes Rifabutin, Rifampicin, Rifapentine, Mupirocin
PF3D7_1347100 DNA topoisomerase 3, putative (TOP3) Y N Y Y N Y DNA-dependent processes Pefloxacin, Novobiocin
PF3D7_1411400
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plastid replication-repair enzyme (PREX) Y N Y Y Y Y DNA-dependent processes Azelaic Acid
PF3D7_1433500
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DNA topoisomerase II, putative Y Y Y Y Y Y DNA-dependent processes Novobiocin, Rosoxacin, Ciprofloxacin
PF3D7_1472700 DNA-directed RNA polymerase, alpha subunit, putative Y N Y Y N Y DNA-dependent processes Rifabutin
PFC10_API0015 RNA polymerase B (rpoB) N N N N Y Y DNA-dependent processes Rifabutin, Rifampicin, Rifaximin
PF3D7_0409500 conserved Plasmodium protein, unknown function Y Y Y Y Y Y Metabolic processes Triclosan
PF3D7_0417200
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bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) Y Y Y Y Y N Metabolic processes Isoniazid
PF3D7_0422000 steroid dehydrogenase, putative Y Y Y Y N Y Metabolic processes Triclosan
PF3D7_0615100
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enoyl-acyl carrier reductase (ENR) Y Y N N N Y Metabolic processes Ethionamide, Isoniazid, Triclosan
PF3D7_0616800 malate:quinone oxidoreductase, putative Y N Y Y Y Y Metabolic processes Azelaic Acid
PF3D7_0618500
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malate dehydrogenase (MDH) N N Y Y N Y Metabolic processes Nitrofural
PF3D7_0626100 oxidoreductase, short-chain dehydrogenase family, putative Y Y Y Y N Y Metabolic processes Triclosan
PF3D7_0720400 ferrodoxin reductase-like protein Y N Y Y Y Y Metabolic processes Azelaic Acid
PF3D7_0810800
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dihydropteroate synthetase (DHPS) Y Y Y Y Y N Metabolic processes Sulfanilamide, Sulfisoxazole, Sulfamethizole, Sulfacetamide, Sulfamethoxazole, Sulfacytine, Sulfamerazine, Sulfamethazine, Sulfaphenazole, Sulfacetamide, Dapsone
PF3D7_0815900
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lipoamide dehydrogenase (aLipDH) Y Y Y N N Y Metabolic processes Azelaic Acid, Nitrofural
PF3D7_0915000
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type II NADH:ubiquinone oxidoreductase (NDH2) N N Y Y Y Y Metabolic processes Azelaic Acid
PF3D7_0922900
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3-oxoacyl-[acyl-carrier-protein] reductase (FabG) Y Y Y N N Y Metabolic processes Triclosan
PF3D7_0923800
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thioredoxin reductase (TRXR) N N Y Y N Y Metabolic processes Azelaic Acid, Nitrofural
PF3D7_1034400
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flavoprotein subunit of succinate dehydrogenase Y N Y Y Y Y Metabolic processes Azelaic Acid, Thiabendazole, Albendazole
PF3D7_1232200
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dihydrolipoyl dehydrogenase, mitochondrial (LPD1) Y Y Y Y Y Y Metabolic processes Azelaic Acid, Nitrofural
PF3D7_1324800
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dihydrofolate synthase/folylpolyglutamate synthase (DHFS-FPGS) Y N Y Y Y N Metabolic processes Sulfamethoxazole
PF3D7_1324900
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L-lactate dehydrogenase (LDH) Y Y Y Y Y Y Metabolic processes Nitrofural
PF3D7_1325200
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oxidoreductase, putative Y Y Y N N Y Metabolic processes Nitrofural
PF3D7_1419800
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glutathione reductase (GR) Y N Y Y Y Y Metabolic processes Azelaic Acid, Nitrofural
PF3D7_1435300
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NAD(P)H-dependent glutamate synthase, putative Y N Y Y Y Y Metabolic processes Azelaic Acid
PF3D7_0422300
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alpha tubulin 2 Y Y Y Y N Y Microtubule-associated processes Griseofulvin, Albendazole
PF3D7_0723500 dynactin subunit 5, putative Y Y N N Y Y Microtubule-associated processes Dalfopristin
PF3D7_0803700
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tubulin gamma chain (g-tub) N Y Y Y Y Y Microtubule-associated processes Griseofulvin, Albendazole
PF3D7_0903700
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alpha tubulin 1 Y Y Y Y Y Y Microtubule-associated processes Griseofulvin, Albendazole
PF3D7_0933800 delta tubulin, putative Y N N Y Y Y Microtubule-associated processes Griseofulvin, Albendazole
PF3D7_1008700
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tubulin beta chain Y Y Y Y Y Y Microtubule-associated processes Griseofulvin, Albendazole
PF3D7_1475700 tubulin epsilon chain, putative Y Y N N Y Y Microtubule-associated processes Albendazole, Griseofulvin
PF3D7_0110100 selenocysteine-specific elongation factor selB homologue, putative Y N Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_0306900 40S ribosomal protein S23, putative Y Y Y Y Y Y Protein biosynthesis Framycetin, Amikacin, Tigecycline, Tobramycin, Gentamicin, Spectinomycin, Netilmicin, Neomycin, Streptomycin, Kanamycin, Arbekacin
PF3D7_0311200 valine--tRNA ligase, putative Y Y Y Y Y N Protein biosynthesis Mupirocin
PF3D7_0412100 mitochondrial ribosomal protein S12 precursor, putative N N Y Y Y N Protein biosynthesis Framycetin, Amikacin, Tigecycline, Tobramycin, Gentamicin, Spectinomycin, Netilmicin, Neomycin, Streptomycin, Kanamycin, Arbekacin
PF3D7_0520000 40S ribosomal protein S9, putative Y Y Y Y Y Y Protein biosynthesis Lymecycline, Clomocycline, Oxytetracycline, Demeclocycline, Minocycline
PF3D7_0602400
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elongation factor G (EF-G) N Y Y Y Y N Protein biosynthesis Fusidic Acid
PF3D7_0622800
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leucine--tRNA ligase, putative N Y Y N Y N Protein biosynthesis Mupirocin
PF3D7_0715600 GTP-binding translation elongation factor tu family protein, putative N N Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_0813900 40S ribosomal protein S16, putative Y Y Y Y Y Y Protein biosynthesis Lymecycline, Clomocycline, Tigecycline, Oxytetracycline, Demeclocycline, Minocycline, Rolitetracycline
PF3D7_0822000
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mitochondrial ribosomal protein L4 precursor, putative N N Y N Y Y Protein biosynthesis Troleandomycin, Josamycin
PF3D7_0828200 leucine--tRNA ligase, putative Y N Y N Y Y Protein biosynthesis Mupirocin
PF3D7_0911700 GTP-binding protein, putative Y Y Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_0918200 50S ribosomal protein L3, apicoplast, putative N Y Y Y Y Y Protein biosynthesis Retapamulin
PF3D7_0931000 elongation factor Tu, putative Y Y Y N Y Y Protein biosynthesis Fusidic Acid
PF3D7_1003500 40S ribosomal protein S20e, putative N Y Y Y Y Y Protein biosynthesis Nitrofurantoin, Paromomycin
PF3D7_1003800 U5 small nuclear ribonuclear protein, putative N Y Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_1005000
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methionine--tRNA ligase, putative Y Y Y N Y Y Protein biosynthesis Mupirocin
PF3D7_1015200
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cysteine--tRNA ligase, putative (CysRS) Y Y Y Y Y Y Protein biosynthesis Mupirocin
PF3D7_1027800 60S ribosomal protein L3 (RPL3) N Y Y Y Y N Protein biosynthesis Retapamulin
PF3D7_1034900
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methionine--tRNA ligase, putative Y Y Y Y Y N Protein biosynthesis Mupirocin
PF3D7_1126200 40S ribosomal protein S18, putative Y Y Y Y Y Y Protein biosynthesis Tigecycline
PF3D7_1137100 mitochondrial ribosomal protein S9 precursor, putative Y Y Y Y Y N Protein biosynthesis Lymecycline, Clomocycline, Tigecycline, Oxytetracycline, Demeclocycline, Minocycline, Rolitetracycline
PF3D7_1137500
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apicoplast ribosomal protein S14p/S29e precursor, putative Y N Y Y N Y Protein biosynthesis Tigecycline
PF3D7_1225100
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isoleucine--tRNA ligase, putative Y N Y Y Y Y Protein biosynthesis Mupirocin
PF3D7_1233000
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elongation factor G (EF-G) Y N Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_1235400
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tetQ family GTPase, putative Y Y Y N Y Y Protein biosynthesis Fusidic Acid
PF3D7_1245400 mitochondrial ribosomal protein L3 precursor, putative Y N Y Y Y Y Protein biosynthesis Retapamulin
PF3D7_1312400
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translation initiation factor IF-2, putative Y Y Y N Y Y Protein biosynthesis Fusidic Acid
PF3D7_1317800 40S ribosomal protein S19 (RPS19) Y Y Y Y Y Y Protein biosynthesis Tigecycline
PF3D7_1332900
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isoleucine--tRNA ligase, putative Y Y Y Y Y Y Protein biosynthesis Mupirocin
PF3D7_1348300
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elongation factor Tu, putative Y Y Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_1404400 mitochondrial ribosomal protein L16 precursor, putative Y N Y Y Y Y Protein biosynthesis Chloramphenicol
PF3D7_1410600 eukaryotic translation initiation factor 2 gamma subunit, putative Y Y Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_1413400 30S ribosomal protein S9, putative Y N Y Y N Y Protein biosynthesis Lymecycline, Clomocycline, Tigecycline, Oxytetracycline, Demeclocycline, Minocycline, Rolitetracycline
PF3D7_1451100
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elongation factor 2 Y Y Y Y Y Y Protein biosynthesis Fusidic Acid
PF3D7_1460900 apicoplast ribosomal protein S10 precursor, putative N N Y Y N Y Protein biosynthesis Nitrofurantoin, Paromomycin
PF3D7_1461900
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valine--tRNA ligase, putative Y Y Y Y Y Y Protein biosynthesis Mupirocin
PFC10_API0030 apicoplast ribosomal protein S12 (rps12) N Y Y Y Y Y Protein biosynthesis Framycetin, Amikacin, Tigecycline, Tobramycin, Gentamicin, Spectinomycin, Netilmicin, Neomycin, Streptomycin, Kanamycin, Arbekacin
PFC10_API0038 apicoplast ribosomal protein L16 (rpl16) N Y Y N N Y Protein biosynthesis Chloramphenicol
PFC10_API0043
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apicoplast ribosomal protein L4 (rpl4) Y Y Y Y Y N Protein biosynthesis Josamycin
PFC10_API0043
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apicoplast ribosomal protein L4 (rpl4) Y Y Y Y Y N Protein biosynthesis Troleandomycin
PFC10_API0043
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apicoplast ribosomal protein L4 (rpl4) Y Y Y Y Y N Protein biosynthesis Erythromycin
PF3D7_0808000 conserved Plasmodium protein, unknown function Y Y Y N Y Y Proteolysis Sulfanilamide, Sulfisoxazole, Sulfamethizole, Sulfacetamide, Sulfamethoxazole, Sulfacytine, Sulfamerazine, Sulfamethazine, Sulfaphenazole
PF3D7_0808000 conserved Plasmodium protein, unknown function Y Y Y N Y Y Proteolysis Sulfacetamide
PF3D7_1303200 SNARE protein, putative (VAMP8) N N Y Y N Y Transport Triclosan
PF3D7_1117700
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GTP-binding nuclear protein RAN/TC4 (RAN) Y N Y Y Y Y Transport (Nuclear export pathway) Fusidic Acid
Online articles related to Drug-target associations predicted for P. falciparum retrieved from PubMed