Protein structure of PfSRs and expression of P. falciparum serpentine receptors (PfSRs) in the parasite (B) Stage-specific expression of PfSRs in the blood stages of P. falciparum. Expression of PfSRs starts in late trophozoite stage, with maximal expression in schizonts. Scale bar, 5 mm. The images show localization of PfSRs (green) in the trophozoites and schizonts. (C) Localization of PfSRs in schizonts and merozoites of P. falciparum. Co-immunostaining of PfSRs (green) with merozoite surface protein MSP-1 (red) revealed membrane localization of PfSRs in merozoites. Nuclei were counterstained with DAPI (blue). Scale bar, 0.5 mm.

Gupta S, Saini M, Joshi N, Shafi S, Najmi AK, Singh S. Antimalarial and Plasmodium falciparum serpentine receptor 12 targeting effect of FDA approved purinergic receptor antagonist. J Biomol Struct Dyn. 2022 Nov 9:1-14.