PF3D7_1328800 transcriptional regulatory protein sir2a

Transcription sites form a distinct compartment in the nucleus of P. falciparum. Immunofluorescence assay for nascent RNAs of ring stage parasites labeled with BrUTP (BrRNA, green) and the compartments of acetylated H4 (H4ac, active chromatin); a proposed histone marker of nascent transcription (H3K79me3; PfSir2A (silencing compartment); and Nop1 (nucleolar compartment). DNA was labeled by DAPI, in blue. Bars, 1 mm.

Moraes CB, Dorval T, Contreras-Dominguez M, Dossin Fde M, Hansen MA, Genovesio A, Freitas-Junior LH. Transcription sites are developmentally regulated during the asexual cycle of Plasmodium falciparum. PLoS One. 2013;8(2):e55539.

Other associated proteins

PFID Formal Annotation
PF3D7_0610400 histone H3
PF3D7_0617900 histone H3 variant
PF3D7_1105000 histone H4
PF3D7_1333700 histone H3-like centromeric protein CSE4
PF3D7_1407100 rRNA 2'-O-methyltransferase fibrillarin, putative
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