Indirect immunofluorescence assays on air-dried P.falciparum 3D7 segmented schizonts (upper), individual merozoites (lower). Merozoite nuclei are labeled with Hoescht 33342. The scale bar represents 3μm. A typical punctate pattern is seen with partial superposition with the signal produced by the anti-AMA1 mAb 28G2. This is in line with the subcellular localization of PfSUB1 and AMA1 in the exonemes and micronemes, respectively.

Bouillon A, Giganti D, Benedet C, Gorgette O, Pêtres S, Crublet E, Girard-Blanc C, Witkowski B, Ménard D, Nilges M, Mercereau-Puijalon O, Stoven V, Barale JC. In silico screening on the 3D-model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound. J Biol Chem. 2013 288(25):18561-73