You can find more information about 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase using the following links:

PDB protein strucure

• 4C81
• 4C82

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
2C-methyl-d-erythritol 2,4-cyclodiphosphate	Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy(2006)
Biochemical characterization, suggested target	Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum(2001)
Crystal structure, suggested target	Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development(2002)
Metabolic control analysis and in silico inhibition studies, ketoclomazone	Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum(2013)
Metabolic network analysis, suggested target	Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis(2010)
N,N'-(4,5-Dibromo-1,2-phenylene)bis(4-bromobenzenesulfonamide)	Aryl Bis-Sulfonamide Inhibitors of IspF from Arabidopsis thaliana and Plasmodium falciparum(2015)
N,N'-(4,5-Dinitro-1,2-phenylene)bis(4-methylbenzenesulfonamide)	Aryl Bis-Sulfonamide Inhibitors of IspF from Arabidopsis thaliana and Plasmodium falciparum(2015)
Suggested target	Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni(2004) Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment(2014)