You can find more information about
DNA mismatch repair protein MLH
using the following links:
PlasmoDB - the Plasmodium genome resource
The TDR Targets Database
Subcellular Localization
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Affecting Drugs
Drug Name
PubMed Articles (year of publication)
Biological characterization suggested target
Plasmodium falciparum MLH is schizont stage specific endonuclease(2012)
Daunorubicin
ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth(2017)
Ethidium bromide
ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth(2017)
etoposide
ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth(2017)
Netropsin
ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth(2017)
nogalamycin a
ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth(2017)
Present in rapid production of drug resistance, suggested target
Malaria drug resistance is associated with defective DNA mismatch repair(2011)