You can find more information about DNA topoisomerase 2 using the following links:

PDB protein strucure

• 6CA8

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
3,6-Diamino-9-[ (4-hydroxyphenyl)amino]acridine	Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum(1994)
3,6-Diamino-9-[ (4-methoxyphenyl)amino]acridine	Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum(1994)
3,6-Diamino-9-[(4-aminophenyl)amino]acridine	Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum(1994)
3,6-diamino-9-anilinoacridine	Cleavage of DNA induced by 9-anilinoacridine inhibitors of topoisomerase II in the malaria parasite Plasmodium falciparum(2000)
3,6-diamino-9-anilinoacridines	Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum(1994) Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis(2010)
4-[(3,6-Diamino-9-acridinyl)amino]benzenecarboxamide	Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum(1994)
8-bromo-2-fluoro-5-methyl-5H-indolo[3,2-c]quinoline	Proteomic analysis of Plasmodium falciparum response to isocryptolepine derivative(2019)
9-anilinoacridine	Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum(1994) Inhibitory effects of 9-anilinoacridines on Plasmodium falciparum gametocytes(2001) Antimalarial 9-anilinoacridine compounds directed at hematin(2003)
Amsacrine	Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro(2000) Partial purification of mitochondrial DNA topoisomerase II from Plasmodium falciparum and its sensitivity to inhibitors(2001)
Antisense nanoparticles	Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols(2006)
Cationic nanoemulsions	Adsorption of antisense oligonucleotides targeting malarial topoisomerase II on cationic nanoemulsions optimized by a full factorial design(2014)
Chloroquine	Cleavage of DNA induced by 9-anilinoacridine inhibitors of topoisomerase II in the malaria parasite Plasmodium falciparum(2000)
ciprofloxacin	Partial purification of mitochondrial DNA topoisomerase II from Plasmodium falciparum and its sensitivity to inhibitors(2001) Quinolone-based drugs against Toxoplasma gondii and Plasmodium spp(2005) Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION(2015)
dsRNA targeting PfTOP2 complexd with chitosan nanoparticles	Inhibition of Plasmodium falciparum proliferation in vitro by double-stranded RNA nanoparticle against malaria topoisomerase II(2016)
Epirubicin	Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets(2017)
etoposide	Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro(2000) Partial purification of mitochondrial DNA topoisomerase II from Plasmodium falciparum and its sensitivity to inhibitors(2001) Evidence on the chromosomal location of centromeric DNA in Plasmodium falciparum from etoposide-mediated topoisomerase-II cleavage(2006) Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION(2015)
Finafloxacin	Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets(2017)
gatifloxacin	Quinolone-based drugs against Toxoplasma gondii and Plasmodium spp(2005)
grepafloxacin	Quinolone-based drugs against Toxoplasma gondii and Plasmodium spp(2005)
GSK299423	Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION(2015)
moxifloxacin	Quinolone-based drugs against Toxoplasma gondii and Plasmodium spp(2005)
N-[4-[(3,6-diaminoacridin-9-yl)amino]phenyl]methanesulfonamide	Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum(1994)
Norfloxacin	Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro(2000) Partial purification of mitochondrial DNA topoisomerase II from Plasmodium falciparum and its sensitivity to inhibitors(2001)
Ofloxacin	Partial purification of mitochondrial DNA topoisomerase II from Plasmodium falciparum and its sensitivity to inhibitors(2001)
Oligonucleotide-loaded nanoemulsion	Cationic nanoemulsion as a delivery system for oligonucleotides targeting malarial topoisomerase II(2011)
Phosphorothioate	Inhibition of Plasmodium falciparum proliferation in vitro by antisense oligodeoxynucleotides against malarial topoisomerase II(2003)
Pyronaridine	Cleavage of DNA induced by 9-anilinoacridine inhibitors of topoisomerase II in the malaria parasite Plasmodium falciparum(2000) Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro(2000)