You can find more information about GTP cyclohydrolase I using the following links:

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
6- (phenylhydrazino)uracil, s 6-(p-n-heptylanilino)uracil	Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I(2014)
8-oxo-GTP	Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I(2014)
Gene amplification	Origin of robustness in generating drug-resistant malaria parasites(2014)
increased copy number	Expansion of GTP cyclohydrolase I copy number in malaria parasites resistant to a pyrimidine biosynthesis inhibitor(2023)
Protein expression, suggested target	Co-expression of the Plasmodium falciparum molecular chaperone, PfHsp70, improves the heterologous production of the antimalarial drug target GTP cyclohydrolase I, PfGCHI(2011)