You can find more information about
Geranyltranstransferase, dimethylallyltranstransferase
using the following links:
PlasmoDB - the Plasmodium genome resource
The TDR Targets Database
Subcellular Localization
Picture 1
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
[2-(3-dodecylimidazol-1-yl)-1-hydroxy-1-phosphono-ethyl]-hydroxy-phosphinate
Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase(2016)
Aminomethylene bisphosphonates
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo(2004)
Bisphosphonate
Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy(2001)
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo(2004)
Bisquinoline
Pharmacophoric studies of in vitro inhibition of Plasmodium falciparum growth(2012)
MMV019313
Specific Inhibition of the Bifunctional Farnesyl/Geranylgeranyl Diphosphate Synthase in Malaria Parasites via a New Small-Molecule Binding Site(2018)
N-(2-(2,4-difluorophenyl)thiazol-5-yl)-4-(1,4-oxazepan-4-yl)butanamide
Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS(2021)
N-[3-(1-Azepanyl)propyl]-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]quinoline-2-carboxamide
Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery(2018)
Risedronate
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo(2004)
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity(2012)
Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum(2013)
Plasmodium falciparum parasites overexpressing farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase are more resistant to risedronate(2018)
Zoledronate
Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity(2012)
Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase(2016)
Remarkable similarity in Plasmodium falciparum and Plasmodium vivax geranylgeranyl diphosphate synthase dynamics and its implication for antimalarial drug design(2018)