You can find more information about L-lactate dehydrogenase using the following links:

Subcellular Localization

• Picture 1

PDB protein strucure

• 1U5A
• 1LDG
• 1CET
• 1CEQ
• 2X8L
• 1T26
• IT24
• 1T2D
• 1T2C
• 1U4O
• 1U5C
• 1T2E
• 1XIV
• 1T25
• 2A94
• 1U4S
• 3ZH2
• 4B7U
• 4PLZ
• 1T24

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(‐)‐Cycloxanthochymol	Biological Activity Evaluation and In Silico Studies of Polyprenylated Benzophenones from Garcinia celebica(2021)
(2R,3aS,6aR,8S)-1,2,3,3a,4,5,6,6a,7,8-Decahydro-8-methyl-2-pentyl-1,9,9b-triazaphenalene	Docking Based 3D-QSAR Study of Tricyclic Guanidine Analogues of Batzelladine K As Anti-Malarial Agents(2017)
(3S,5a'R,8'S,9'R,9a'S,10a'S)-1-(2-chloro-4-methoxybenzyl)-8'-((2-chloro-4-methoxybenzyl)oxy)-9'-(dimethoxymethyl)-2',3',5a',6',7',8',9',9a',10',10a'-decahydro-5'H-spiro[indoline-3,1'-pyrrolo[1,2-b]isoquinolin]-2-one	Re-Engineering of Yohimbine's Biological Activity through Ring Distortion: Identification and Structure-Activity Relationships of a New Class of Antiplasmodial Agents(2020)
(4aR,6aR,9R,11aR)-4,4-dimethyl-1,2,3,4,4a,5,6,9,10,11,11a,11b-dodecahydro-6a,9-methanocyclohepta[a]naphthalene-8-carbaldehyde	Naturally Occurring 8ß,13ß-kaur-15-en-17-al and Anti-Malarial Activity from Podocarpus polystachyus Leaves(2022)
(4R,7R,7aS,12aR,12bR)-1,8,10,11-tetramethoxy-4-methyl-6-((1s,4S)-4-methylcyclohexyl)-7-(2-((1s,4R)-4-methylcyclohexyl)ethyl)tetradecahydro-1H,6H-chromeno[4,3-b]chromene	Highly potent anti-malarial activity of benzopyrano(4,3-b)benzopyran derivatives and in silico interaction analysis with putative target Plasmodium falciparum lactate dehydrogenase(2021)
(E)-N-(2-(5-nitrofuran-2-yl)vinyl)quinazolin-4-amine	In silico and in vivo anti-malarial investigation on 1-(heteroaryl)-2-((5-nitroheteroaryl)methylene) hydrazine derivatives(2020)
2-[4-[2-[5-hydroxy-2-[(4-methoxyphenyl)methylcarbamoyl]-4-oxo-chromen-7-yl]oxyethyl]-2-methyl-anilino]-2-oxo-acetic acid	Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors(2007)
2-[4-[2-[5-hydroxy-2-[(4-methoxyphenyl)methylcarbamoyl]-4-oxo-chromen-7-yl]oxyethyl]anilino]-2-oxo-acetic acid	Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors(2007)
4-(2-hydroxy-4-methoxyphenyl)-4-oxobutanoic acid	Design of novel dihydroxynaphthoic acid inhibitors of Plasmodium falciparum lactate dehydrogenase(2012)
4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid	Synthesis and Evaluation of N-(3-Trifluoroacetyl-indol-7-yl) Acetamides for Potential In Vitro Antiplasmodial Properties(2017)
5-(4-methylbenzylidene)-2-(4-chlorophenyl)-3-(4- methylquinolin-2-ylamino) thiazolidin-4-one	Novel arylidene derivatives of quinoline based thiazolidinones: Synthesis, in vitro, in vivo and in silico study as antimalarials(2018)
7,8-dihydroxy-2h-chromen-2-one	Drug discovery studies on quinoline-based derivatives as potential antimalarial agents(2014)
7-[(4-chlorophenyl)methyl]-2,3-dihydroxy-4-isopropyl-6-methyl-naphthalene-1-carboxylic acid	The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum(2001)
7-benzyl-2,3-dihydroxy-4-isopropyl-6-methyl-naphthalene-1-carboxylic acid	The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum(2001)
7-benzyl-2,3-dihydroxy-6-methyl-4-propyl-naphthalene-1-carboxylic acid	The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum(2001)
alpha-Cadinol	Uncovering the inhibitory potentials of Phyllanthus nivosus leaf and its bioactive compounds against Plasmodium lactate dehydrogenase for malaria therapy(2022)
Amodiaquine	Docking studies on the binding of quinoline derivatives and hematin to Plasmodium falciparum lactate dehydrogenase(2011)
Arjungenin	An Allosteric Inhibitory Potential of Triterpenes from Combretum racemosum on the Structural and Functional Dynamics of Plasmodium falciparum Lactate Dehydrogenase Binding Landscape(2022)
Artemisinin	Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum(2015)
Atorvastatin	Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies(2011)
Azole	Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity(2004)
Biochemical characterization, suggested target	Plasmodium falciparum: enhanced soluble expression, purification and biochemical characterization of lactate dehydrogenase(2008)
Bisindolylmaleimide ii	Identification of potential multitarget antimalarial drugs(2005)
Bisindolylmaleimide x	Identification of potential multitarget antimalarial drugs(2005)
Chloroquine	Docking studies on the binding of quinoline derivatives and hematin to Plasmodium falciparum lactate dehydrogenase(2011)
CTACTGTTGATATGAGTGATAGGGCGGCGCGCTTATCTGTATTGTG aptamer	Towards development of aptamers that specifically bind to lactate dehydrogenase of Plasmodium falciparum through epitopic targeting(2018)
Diaminedialkyne	Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action(2014)
Dihydroxynaphthoic acid	The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum(2001)
ethyl gossypol	Antimalarial activity of new gossypol derivatives(2000)
Extracts of Callistemon citrinus	Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon citrinus(2019)
gentianine	A computational approach to validate novel drug targets of gentianine from Swertiya chirayita in Plasmodium falciparum(2020)
Gossylic iminolactone	The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum(2001)
Gossylic lactone	The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum(2001) Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human malarial parasites(2004)
Gossylic nitrile 1,1′-diacetate	Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human malarial parasites(2004)
Gossylic nitrile 1,1-diacetate	The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum(2001)
Gossylic nitrile 1,1-divalerate	The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum(2001)
Gossypol	Antimalarial activity of new gossypol derivatives(2000) The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum(2001) Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human malarial parasites(2004)
Hydroxychloroquine	Docking studies on the binding of quinoline derivatives and hematin to Plasmodium falciparum lactate dehydrogenase(2011)
isopropyl gossypol	Antimalarial activity of new gossypol derivatives(2000)
Itraconazole	Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies(2011)
Mefloquine	Docking studies on the binding of quinoline derivatives and hematin to Plasmodium falciparum lactate dehydrogenase(2011)
Methyl gossypol	Antimalarial activity of new gossypol derivatives(2000)
Methylgene_05	Identification of potential multitarget antimalarial drugs(2005)
N-(2,5-Bis(4-fluorophenyl)-3-(2,2,2-trifluoroacetyl)-1H-indol-7-yl) Acetamide	Synthesis and Evaluation of N-(3-Trifluoroacetyl-indol-7-yl) Acetamides for Potential In Vitro Antiplasmodial Properties(2017)
Oxamic acid	Generation of oxamic acid libraries: antimalarials and inhibitors of Plasmodium falciparum lactate dehydrogenase(2007) Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors(2007)
Oxamic esters	Generation of oxamic acid libraries: antimalarials and inhibitors of Plasmodium falciparum lactate dehydrogenase(2007)
Oxd1	Plasmodium falciparum: stage specific effects of a selective inhibitor of lactate dehydrogenase(2005)
Posaconazole	Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies(2011)
propyl gossypol	Antimalarial activity of new gossypol derivatives(2000)
Quebrachitol	Quebrachitol from Putranjiva roxburghii Wall. (Putranjivaceae) a potent antimalarial: Pre-clinical efficacy and its interaction with PfLDH(2022)
ssDNA aptamer	Aromatic Surfactant as Aggregating Agent for Aptamer-Gold Nanoparticle-Based Detection of Plasmodium Lactate Dehydrogenase(2016)
Sti-571	Identification of potential multitarget antimalarial drugs(2005)
Suggested target	Enzymatic properties of the lactate dehydrogenase enzyme from Plasmodium falciparum(2007) Plasmodium and host lactate dehydrogenase molecular function and biological pathways: implication for antimalarial drug discovery(2007)
Tetrahydro-4-((E)-7-hydroxy-10-methoxy-6, 14-dimethyl-15-m-tolylpentadec-13-enyl) pyran-2- one	A novel compound purified from Alstonia boonei inhibits Plasmodium falciparum lactate dehydrogenase and plasmepsin II(2019)
X-ray crystallography, qsar, 110 7-substituted-4-aminoquinoline derivative	Molecular docking and QSAR analyses for understanding the antimalarial activity of some 7-substituted-4-aminoquinoline derivatives(2015)