You can find more information about PEXEL protease plasmepsin V using the following links:

Subcellular Localization

• Picture 1
• Picture 2
• Picture 3
• Picture 4
• Picture 5
• Picture 6
• Picture 7
• Picture 8
• Picture 9
• Picture 10
• Picture 11
• Picture 12
• Picture 13
• Picture 14
• Picture 15
• Picture 16
• Picture 17
• Picture 18
• Picture 19
• Picture 20
• Picture 21
• Picture 22
• Picture 23
• Picture 24
• Picture 25
• Picture 26
• Picture 27
• Picture 28
• Picture 29
• Picture 30
• Picture 31
• Picture 32
• Picture 33
• Picture 34
• Picture 35
• Picture 36
• Picture 37
• Picture 38

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(3s,4r,5s)-4-((s)-2-((s)-5-guanidino-2-(phenylmethylsulfonamido)pentanamido)-3-methylbutanamido)-3-hydroxy-5-methyl-n-phenethylheptanamide	Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites(2014)
(3S,4S)-4-((9S,12S,Z)-4-amino-1,1,1-trifluoro-2,10-dioxo-12-phenyl-9-(3-phenylpropanamido)-6-oxa-3,5,11-triazatridec-3-en-13-amido)-3-hydroxy-6-methyl-N-phenethylheptanamide	Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P 2 position of PEXEL peptidomimetics(2018)
(3s,4s)-4-((s)-2-((s)-5-guanidino-2-(phenylmethylsulfonamido)pentanamido)-3-methylbutanamido)-3-hydroxy-6-methyl-n-phenethylheptanamide	Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites(2014)
(3s,4s)-4-((s)-2-((s)-6-amino-2-(phenylmethylsulfonamido)hexanamido)-3-methylbutanamido)-3-hydroxy-6-methyl-n-phenethylheptanamide	Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites(2014)
(4R)-N-tert-Butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide	The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active(2014)
(R)-3-((2S,3S)-3-(2-(4-((2-(dimethylamino)ethyl)(methyl)amino)-2,6-dimethylphenoxy)acetamido)-2-hydroxy-4-phenylbutanoyl)-N-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-5,5-dimethylthiazolidine-4-carboxamide	The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active(2014)
(R)-3-((2S,3S)-3-(2-(4-((2-aminoethyl)(ethyl)amino)-2,6-dimethylphenoxy)acetamido)-2-hydroxy-4-phenylbutanoyl)-N-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-5,5-dimethylthiazolidine-4-carboxamide	The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active(2014)
[acetyl-[4-[[(Z)-N'-tert-butoxycarbonyl-N-(1-tert-butoxyvinyl)carbamimidoyl]amino]butyl]carbamoyl]carbamic acid	Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax(2014)
1,10-phenanthroline	The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active(2014)
3-(3-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2,2-dimethylpropyl heptanoate	In vitro and in silico studies of naphthoquinones and peptidomimetics toward Plasmodium falciparum plasmepsin V(2018)
4-[[2-[[4-guanidinooxy-2-[(1-methylene-3-phenyl-propyl)amino]butanoyl]amino]-3-methyl-butanoyl]amino]-3-hydroxy-6-methyl-N-(2-phenylethyl)heptanamide	The binding landscape of plasmepsin V and the implications for flap dynamics(2016)
7-(2-amino-2-oxoethyl)-2-(2-hydroxyphenyl)-3-(p-tolylamino)imidazo[1,2-a]pyrazin-7-ium	In Silico and In Vitro Antimalarial Screening and Validation Targeting Plasmodium falciparum Plasmepsin V(2022)
Cu2+	The zymogen of plasmepsin V from Plasmodium falciparum is enzymatically active(2014)
diamino-[5-(benzylsulfonylamino)-6-[[1-[[2-hydroxy-1-isobutyl-4-oxo-4-(2-phenylethylamino)butyl]carbamoyl]-2-methyl-propyl]amino]-6-oxo-hexylidene]ammonium	The binding landscape of plasmepsin V and the implications for flap dynamics(2016)
Diphenylurea	Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
fosmidomycin	Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites(2014)
KNI10006	Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors(2016)
KNI764	Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors(2016)
Lopinavir	An aspartyl protease directs malaria effector proteins to the host cell(2010) Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte(2010)
menisporopsin A	Biochemical characterization of plasmepsin V from Plasmodium vivax Thailand isolates: Substrate specificity and enzyme inhibition(2015)
N1-(3-hydroxy-1-phenyl-4-(4-(piperidin-4-yl)piperazin-1-yl)butan-2-yl)-N3-phenylmalonamide	In silico validation of novel inhibitors of malarial aspartyl protease, plasmepsin V and antimalarial efficacy prediction(2021)
N2-(Benzylsulfonyl)-L-arginyl-N-{(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]-4-heptanyl}-L-valinamide	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery(2018)
N2-[(Benzyloxy)carbonyl]-L-arginyl-N-{(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]-4-heptanyl}-L-valinamide	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery(2018)
Nelfinavir	An aspartyl protease directs malaria effector proteins to the host cell(2010) Plasmodium falciparum Plasmepsin V (PfPMV): Insights into recombinant expression, substrate specificity and active site structure(2015) Biochemical characterization of plasmepsin V from Plasmodium vivax Thailand isolates: Substrate specificity and enzyme inhibition(2015)
Pepstatin	Characterization of plasmepsin V, a membrane-bound aspartic protease homolog in the endoplasmic reticulum of Plasmodium falciparum(2005) Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte(2010)
Pepstatin a	Biochemical characterization of plasmepsin V from Plasmodium vivax Thailand isolates: Substrate specificity and enzyme inhibition(2015)
Phenylmethanesulfonyl fluoride	Biochemical characterization of plasmepsin V from Plasmodium vivax Thailand isolates: Substrate specificity and enzyme inhibition(2015)
Pmsf	Plasmodium falciparum Plasmepsin V (PfPMV): Insights into recombinant expression, substrate specificity and active site structure(2015)
Ritonavir	An aspartyl protease directs malaria effector proteins to the host cell(2010) Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte(2010)
Saquinavir	An aspartyl protease directs malaria effector proteins to the host cell(2010) Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors(2016)
Three-dimensional model, suggested target	Structural rationale for the recognition of arginine at P3 in PEXEL motif containing proteins of Plasmodium falciparum by plasmepsin V(2011)
Transition state mimetics of the native pexel substrate	Transition state mimetics of the Plasmodium export element are potent inhibitors of Plasmepsin V from P. falciparum and P. vivax(2014)
WEHI-842	Targeting Plasmodium Plasmepsin V: Hitting Two Birds with One Stone(2020)
ZINC03351002	Unveiling a New Era in Malaria Therapeutics: A Tailored Molecular Approach Towards the Design of Plasmepsin IX Inhibitors(2019)
ZINC72012008	Targeting the Plasmodium falciparum plasmepsin V by ligand-based virtual screening(2019)