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Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(1E,4E)-1,5-bis(4-methoxyphenyl)penta-1,4-dien-3-one	Design, in silico and in vitro evaluation of curcumin analogues against Plasmodium falciparum(2017)
(1E,4E)-1,5-bis(4-methylphenyl)penta-1,4-dien-3- one	Design, in silico and in vitro evaluation of curcumin analogues against Plasmodium falciparum(2017)
(1R,3R,5aS,5bR,9S,11aR)-3-((3-(4-(3-aminopropyl)piperazin-1-yl)propyl)carbamoyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-yl acetate	SERCA plays a crucial role in the toxicity of a betulinic acid derivative with potential antimalarial activity(2018)
(3R,5aalpha,8aalpha,12aR)-10beta-(6-Oxotetrahydro-2H-pyran-2-yl)decahydro-3,6alpha,9beta-trimethyl-3beta,12alpha-epoxypyrano[4,3-j]-1,2-benzodioxepin	Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach(2016)
(4S,5E,8S,9E,11S,13E,15E,18R)-4-(((2R,3R,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-methoxytetrahydro-2H-pyran-2-yl)oxy)-8-methoxy-9,11-dimethyl-18-((1Z,4E)-2-methylhexa-1,4-dien-1-yl)oxacyclooctadeca-5,9,13,15-tetraen-2-one	Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca 2+ pump inhibitor from marine cyanobacteria(2018)
(E)-1-(3-phenyl-1-(p-tolylamino)allyl)urea	Octopus: a platform for the virtual high-throughput screening of a pool of compounds against a set of molecular targets(2017)
(E)-1,3- bis(4-hydroxylphenyl)prop-2-en-1-one	Design, in silico and in vitro evaluation of curcumin analogues against Plasmodium falciparum(2017)
1,2,4,5-tetraoxane	Docking studies of structurally diverse antimalarial drugs targeting PfATP6: no correlation between in silico binding affinity and in vitro antimalarial activity(2009)
1,2,4-tri-oxane	Docking studies of structurally diverse antimalarial drugs targeting PfATP6: no correlation between in silico binding affinity and in vitro antimalarial activity(2009)
1,2,4-trioxolane	Docking studies of structurally diverse antimalarial drugs targeting PfATP6: no correlation between in silico binding affinity and in vitro antimalarial activity(2009)
1-benzofuran-2-yl-[4-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl)-1,3-thiazol-2-yl]piperidin-1-yl]methanone	Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca²?-ATPase PfATP6(2015)
2,5-di(tert-butyl)-1,4-benzohydroquinone	Purified E255L mutant SERCA1a and purified PfATP6 are sensitive to SERCA-type inhibitors but insensitive to artemisinins(2010) Antimalarial screening via large-scale purification of Plasmodium falciparum Ca2+-ATPase 6 and in vitro studies(2013)
4-(3-(3-((4-butylpiperazin-1-yl)(imino)methyl)phenyl)ureido)-N-(4-sulfamoylbenzyl) benzenesulfonamide	SC83288 is a clinical development candidate for the treatment of severe malaria(2017)
AGN-PC-036KA3	Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca²?-ATPase PfATP6(2015)
Artemether	Identification of an antimalarial synthetic trioxolane drug development candidate(2004) Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins(2012)
Artemisinin	Identification of an antimalarial synthetic trioxolane drug development candidate(2004) A single amino acid residue can determine the sensitivity of SERCAs to artemisinins(2005) The effect of dosing regimens on the antimalarial efficacy of dihydroartemisinin-piperaquine: a pooled analysis of individual patient data(2013)
artemisinin dimer	Selective Inhibition of Plasmodium falciparum ATPase 6 by Artemisinins and Identification of New Classes of Inhibitors after Expression in Yeast(2022)
Artemisone	A single amino acid residue can determine the sensitivity of SERCAs to artemisinins(2005) Docking studies of structurally diverse antimalarial drugs targeting PfATP6: no correlation between in silico binding affinity and in vitro antimalarial activity(2009)
Artesunate	Identification of an antimalarial synthetic trioxolane drug development candidate(2004) Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins(2012)
calmidazolium	Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum(2016)
Chembl2172226	Combined receptor-based and ligand-based approach to delineate the mode of binding of guaianolide-endoperoxides to PfATP6(2012)
Chloroquine	Effect of chloroquine phosphate and toxic concentrations of lead acetate on Ca2+-ATPase activity in isolates and clones of Plasmodium falciparum(2011)
CID 10625452	Mechanism of artemisinin resistance for malaria PfATP6 L263 mutations and discovering potential antimalarials: An integrated computational approach(2016)
Crystal structure, suggested target	Combined receptor-based and ligand-based approach to delineate the mode of binding of guaianolide-endoperoxides to PfATP6(2012)
Curcumin	Interactions of curcumin with the PfATP6 model and the implications for its antimalarial mechanism(2009) Inhibition of P. falciparum PFATP6 by curcumin and its derivatives: a bioinformatic study(2012)
Cyclopiazonic acid	Purified E255L mutant SERCA1a and purified PfATP6 are sensitive to SERCA-type inhibitors but insensitive to artemisinins(2010) Antimalarial screening via large-scale purification of Plasmodium falciparum Ca2+-ATPase 6 and in vitro studies(2013)
Dihydroartemisinin	Docking studies of structurally diverse antimalarial drugs targeting PfATP6: no correlation between in silico binding affinity and in vitro antimalarial activity(2009) Lack of association of the S769N mutation in Plasmodium falciparum SERCA (PfATP6) with resistance to artemisinins(2012)
ergosterol5,8-endoperoxide	Steroids from Diplazium esculentum: Antiplasmodial activity and molecular docking studies to investigate their binding modes(2022)
Guaianolide	Combined receptor-based and ligand-based approach to delineate the mode of binding of guaianolide-endoperoxides to PfATP6(2012)
Iron + artemisinin	A plausible mechanism for the antimalarial activity of artemisinin: A computational approach(2013)
Lead diacetate	Effect of chloroquine phosphate and toxic concentrations of lead acetate on Ca2+-ATPase activity in isolates and clones of Plasmodium falciparum(2011)
methyl (2R,3'R,6a'R,6b'R,7a'R)-3',6a'-dimethyldecahydro-9'H,11'H-spiro[oxirane-2,10'-[9,11a]methanonaphtho[1',2':1,7]cyclohepta[1,2-b]oxirene]-3'-carboxylate	Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca²?-ATPase PfATP6(2015)
methyl (3R,6aR,6bR,7aR,10S)-10-hydroxy-10-(hydroxymethyl)-3,6a-dimethyldodecahydro-9H-9,11a-methanonaphtho[1',2':1,7]cyclohepta[1,2-b]oxirene-3-carboxylate	Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca²?-ATPase PfATP6(2015)
methyl (4R,8S,11bS)-8-(hexahydropyrimidin-2-yl)-4,11b-dimethyltetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylate	Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca²?-ATPase PfATP6(2015)
methyl 4-(imino(3-(3-(4-(N-(4-sulfamoylbenzyl)sulfamoyl)phenyl)ureido) phenyl)methyl) piperazine-1-carboxylate	SC83288 is a clinical development candidate for the treatment of severe malaria(2017)
N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-Ohexanoylbetulinamide	Identification of an antimalarial synthetic trioxolane drug development candidate(2004)
Nsc 95397	Antimalarial screening via large-scale purification of Plasmodium falciparum Ca2+-ATPase 6 and in vitro studies(2013)
Oz277	Identification of an antimalarial synthetic trioxolane drug development candidate(2004)
Rbx-11160	Mechanism of antimalarial action of the synthetic trioxolane RBX11160 (OZ277)(2007)
Rh5 antibody	Characterization of the differences in the cyclopiazonic acid binding mode to mammalian and P. Falciparum Ca2+ pumps: a computational study(2015)
Simulated noncompetitive inhibitors	The binding modes and binding affinities of artemisinin derivatives with Plasmodium falciparum Ca2+-ATPase (PfATP6)(2011)
Thaperoxide	Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents(2010)
Thapsigargin	Plasmodium falciparum malaria parasites display a THG-sensitive Ca2+ pool(2003) Purified E255L mutant SERCA1a and purified PfATP6 are sensitive to SERCA-type inhibitors but insensitive to artemisinins(2010) Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents(2010) Antimalarial screening via large-scale purification of Plasmodium falciparum Ca2+-ATPase 6 and in vitro studies(2013) Calmidazolium evokes high calcium fluctuations in Plasmodium falciparum(2016) Fragment Molecular Orbital Study of the Interaction between Sarco/Endoplasmic Reticulum Ca 2+-ATPase and its Inhibitor Thapsigargin toward Anti-Malarial Development(2018)