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Subcellular Localization

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Affecting Drugs
Drug Name	PubMed Articles (year of publication)
Alln	Antimalarial effect of N-acetyl-L-Leucyl-L-leucyl-L-norleucinal by the inhibition of Plasmodium falciparum Calpain(2009) Synthesis and evaluation of peptidyl a,ß-unsaturated carbonyl derivatives as anti-malarial calpain inhibitors(2012) Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development(2013) Potential Interaction of Plasmodium falciparum Hsp60 and Calpain(2015)
Bapta	Cysteine-protease activity elicited by Ca2+ stimulus in Plasmodium(2005)
Bda-410	BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria(2007)
Celastrol	Specific calpain activity evaluation in Plasmodium parasites(2015)
E-64	Cysteine-protease activity elicited by Ca2+ stimulus in Plasmodium(2005) Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development(2013) Specific calpain activity evaluation in Plasmodium parasites(2015)
mizoribine	Potential Interaction of Plasmodium falciparum Hsp60 and Calpain(2015)
RF05	Hypervalent organotellurium compounds as inhibitors of P. falciparum calcium-dependent cysteine proteases(2016)
RF07	Hypervalent organotellurium compounds as inhibitors of P. falciparum calcium-dependent cysteine proteases(2016)
RF19	Hypervalent organotellurium compounds as inhibitors of P. falciparum calcium-dependent cysteine proteases(2016)
Suggested target	A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development(2009)