You can find more information about
dihydroorotase, putative
using the following links:
PlasmoDB - the Plasmodium genome resource
The TDR Targets Database
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
5-amino orotate
Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase(1992)
5-bromo orotate
Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase(1992)
5-fluoroorotate
Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase(1992)
5-methyl orotate
Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase(1992)
dynasore
Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase(1992)
genz-669178
Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance(2014)
Suggested target
Cloning and expression of malarial pyrimidine enzymes(2004)
Tdho
dCTP levels are maintained in Plasmodium falciparum subjected to pyrimidine deficiency or excess(1997)
Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis(2010)