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Subcellular Localization

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Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(−)-Epigallocatechin-3-gallate	(-)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners(2017)
15-deoxyspergualine	An Undefined Interaction between Polyamines and Heat Shock Proteins Leads to Cellular Protection in Plasmodium falciparum and Proliferating Cells in Various Organisms(2023)
15-Desoxyspergualin	15-Deoxyspergualin modulates Plasmodium falciparum heat shock protein function(2006)
4-(4-(4,6-bis(4-methoxyphenyl)pyrimidin-2-yl)piperazin-1-yl)-7-chloroquinoline	Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors(2021)
Chloroquine	Chloroquine mediates specific proteome oxidative damage across the erythrocytic cycle of resistant Plasmodium falciparum(2008)
DMT-2264	Effect of a-Tocopheryloxy Acetic Acid on the Infection of Mice with Plasmodium berghei ANKA In Vivo and Humans with P. falciparum In Vitro(2022)
EGCG	HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets(2022)
iso-mukaadial acetate	Iso-mukaadial acetate and ursolic acid acetate inhibit the chaperone activity of Plasmodium falciparum heat shock protein 70-1(2021)
Ly294002	Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death(2020)
MAL3-39	HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets(2022)
Malonganenone a	Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity(2014) HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets(2022)
Malonganenone C	HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets(2022)
MKT-077	HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets(2022)
P. angolensis and Z. mucronata Extracts	Extracts Obtained from Pterocarpus angolensis DC and Ziziphus mucronata Exhibit Antiplasmodial Activity and Inhibit Heat Shock Protein 70 (Hsp70) Function(2017)
plakortin	Oxidative stress-mediated antimalarial activity of plakortin, a natural endoperoxide from the tropical sponge Plakortis simplex(2015)
Polymyxin b	Polymyxin B inhibits the chaperone activity of Plasmodium falciparum Hsp70(2017)
Pyrimidinones	Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum(2009)
Transit peptide	Exploring the positional importance of aromatic residues and lysine in the interactions of peptides with the Plasmodium falciparum Hsp70-1(2010)
Violacein	Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity(2021) HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets(2022)
Warburganal	Establishing Computational Approaches Towards Identifying Malarial Allosteric Modulators: A Case Study of Plasmodium falciparum Hsp70s(2019)