You can find more information about plasmepsin IV using the following links:

PlasmoDB - the Plasmodium genome resource
The TDR Targets Database

Subcellular Localization

PDB protein strucure

Affecting Drugs
Drug Name PubMed Articles (year of publication)
(2R,3R,4R)-2-Benzyloxy-3,4-dihydroxy-N-[(1S,2R)- 2-hydroxyindan-1-yl]-4-[(2R)-3-oxo-1-oxa-4-aza-cyclotridec-2-yl]-butyramide
(3R,4R)-3-benzyl-4-hydroxy-7-(3-methoxyphenyl)-7-methyl-1-(3-(2-propylpentanoyl)phenyl)octan-1-one
(4R)-3-[(2S,3S)-3-[[(2R)-2-[[2-(4-aminophenyl)acetyl]amino]-3-methylsulfanylpropanoyl]amino]-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide
(4R)-N-tert-Butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide
(S)-N-((2R,3S)-4-(4-(4-Bromobenzyl)piperazin-1-yl)-3-hydroxy-1-phenylbutan-2-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanamide.
(S)-N-((2R,3S)-4-(4-(4-Fluorobenzyl)piperazin-1-yl)-3-hydroxy-1-phenylbutan-2-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanamide.
[amino({5-phenyl-3-[(E)-2-phenylethenyl]- 4,5-dihydro-1H-pyrazol-1-yl})methylidene]azanium
1-[2-methoxy-5-[(1E)-3-phenylbuta-1,3-dienyl]phenyl]sulfonylpyridine
1-[2-methoxy-5-[(1E)-3-phenylbuta-1,3-dienyl]phenyl]sulfonylpyrrolidine
11-azatricyclo[6.2.1.02,7]undeca-2(7),3,5-triene tricycle
13- and 16-membred macrocycles
2,3,4,7-tetrahydro-1h-azepine
2-Amino-3-(((2S*,5R*)-5-isopropyltetrahydrofuran-2-yl)methyl)-7- phenylquinazolin-4(3H)-one
2-Amino-7-phenyl-3-(((2R,5S)-5-phenyltetrahydrofuran-2-yl)methyl)quinazolin- 4(3H)-one
2-Amino-7-phenyl-3-(((2S*,5R*)-5-phenyltetrahydrofuran-2- yl)methyl)quinazolin-4(3H)-one
3-(7-(4-(4l3-butyl)phenyl)-2-amino-4-oxo-3-((tetrahydrofuran-2-yl)methyl)-3,4-dihydroquinazolin-5-yl)propanoic acid
4-[2-methoxy-5-[(1E)-3-phenylbuta-1,3-dienyl]phenyl]sulfonylmorpholine
4-aminopiperidine
4-aminoquinoline
7-azabicyclo[2.2.1]heptane
Alln
Allophenylnorstatine
Aminohydantoin
Atazanavir
Atovaquone
Benzophenone
Catestatin
Diphenylurea
E-64
G16
Guanidino
Indinavir
Kni-10740
Kni-10823
Kni-764
Leupeptin
Ligand based virtual screening, mdg419, mdg421, mdg422, mdg425, mdg426, mdg427, mdg430, mdg432
Lopinavir
N,N'-((2R,2'R,3S,3'S)-piperazine-1,4-diylbis(3-hydroxy-1-phenylbutane-4,2-diyl))bis(2-(1,3-dioxoisoindolin-2-yl)-3 phenylpropanamide)
N1-((2S,3R)-1-cyclohexyl-3-hydroxy-4-((2-(3-methoxyphenyl)propan-2-yl)amino)butan-2-yl)-5-(piperidin-1-yl)-N3-(3,3,3-trifluoropropyl)isophthalamide
N-acetyl-l-leucyl-l-leucyl-norleucinal
N-alkyl chains
N-benzyl-2-methoxy-5-[(1E)-3-phenylbuta-1,3-dienyl]benzenesulfonamide
Nelfinavir
Norstatines
Pepstatin a
Plm iv selective symmetrical nonpeptidic inhibitor 18
Purine
Ritonavir
Ro 40-4388
Saquinavir
Statine
Suggested target
Sulfonamide 4-metychalcone
Tcmdc-134527
Tcmdc-134674
tert-butyl ((S)-1-(((2S,3S)-4-(4-((2S,3R)-3-((S)-2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-2-hydroxy-4-phenylbutyl)piperazin-1-yl)-3-hydroxy-1-phenylbutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate
tert-Butyl((2R,3S)-4-([1,4'-bipiperidin]-1'-yl)-3-hydroxy-1-phenylbutan-2-yl)carbamate
Thiourea
X-ray structures and 3d models , suggested target
ZINC03351002