You can find more information about plasmepsin X using the following links:

Subcellular Localization

• Picture 1
• Picture 2
• Picture 3
• Picture 4
• Picture 5
• Picture 6
• Picture 7

PDB protein strucure

• 6ORS

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(1r)-5'-[(2-Chlorophenyl)Sulfanyl]-4'-Hydroxy-2,3-Dihydrospiro[Indene-1,2'-Pyran]-6'(3'H)-One	A dual target of Plasmepsin IX and X: Unveiling the atomistic superiority of a core chemical scaffold in malaria therapy(2018)
(4R)-4-(2-amino-4,4-diethyl-6-oxo-5H-pyrimidin-1-yl)-N-[(4S)-2,2-dimethyl-3,4-dihydrochromen-4-yl]-3,4-dihydro-2H-chromene-6-carboxamide	Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase(2016)
(R)-4-(4,4-diethyl-2-imino-6-oxotetrahydropyrimidin-1(2H)-yl)-N-((S)-2,2-dimethylchroman-4-yl)chromane-6-carboxamide	Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle(2020)
Aliskiren	A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast(2013)
Benzohydrazide	Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase(2016)
CWHM-117	Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion(2017)
Diphenylurea	Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors(2009)
histidylserylphenylalanylisoleucylglutamine	Structures of plasmepsin X from P. falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme(2022)
N-((2R,3S)-3-hydroxy-1-phenyl-4-(((S)-1-phenylethyl)amino)butan-2-yl)-4-(4-methylpiperazine-1-carbonyl)benzamide	Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases(2018)
N-((S)-chroman-4-yl)-3-((R)-1-(4,4-diethyl-2-imino-6-oxotetrahydropyrimidin-1(2H)-yl)butyl)benzamide	The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria(2022)
Remikiren	A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast(2013)
Sucralfate	A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast(2013)
TCMDC-134675	Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion(2017)
TCMDC-136879	Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion(2017)
UCB7362	Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362(2022)