You can find more information about serine hydroxymethyltransferase using the following links:

Subcellular Localization

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PDB protein strucure

• 4O6Z

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(±)-(1-{3-[6-Amino-5-cyano-3-methyl-4-isopropyl-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5- fluorophenyl}piperidin-4-yl)acetic Acid	Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures(2017)
(±)-6-Amino-3-methyl-4-isopropyl-4-[3-(pyridin-4-yl)-5-(trifluoromethyl)phenyl]-2,4- dihydropyrano[2,3-c]pyrazole-5-carbonitrile	Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures(2017)
(±)-Methyl 5-[3-(6-Amino-5-cyano-4- isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazol-4-yl)-5-cyanophenyl]thiophene-2-carboxylate	An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery(2016)
(±)-Methyl 5-[3-(6-Amino-5-cyano-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazol-4-yl)-5-cyanophenyl]-thiophene-2-carboxylate	Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities(2015)
[2-[3-(5-benzyloxycarbonyl-2-thienyl)-5-cyano-phenyl]-4-[hydroxy(methyl)amino]-4-oxo-butyl]phosphonic acid	Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities(2015)
6'-amino-4-fluoro-2,2,3'-trimethyl-6-(pyridin-4-yl)-2,3-dihydro-2'H-spiro[indene-1,4'-pyrano[2,3-c]pyrazole]-5'-carbonitrile	Potent Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT) Featuring a Spirocyclic Scaffold(2018)
Cinnamic acid	Plasmodium serine hydroxymethyltransferase as a potential anti-malarial target: inhibition studies using improved methods for enzyme production and assay(2012)
Novel disulfide/sulfhydryl switch , suggested target	The structure of Plasmodium falciparum serine hydroxymethyltransferase reveals a novel redox switch that regulates its activities(2014)
Phosphonomethoxyethyl	Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities(2015)
Pyrazolopyran	Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities(2015)
Suggested target	A three-dimensional structure of Plasmodium falciparum serine hydroxymethyltransferase in complex with glycine and 5-formyl-tetrahydrofolate. Homology modeling and molecular dynamics(2005)