Latest Updates

Last update: 11/09/2022

  • 11/09/2022

    The general ATPase cycle of HSP70 we summarize the current state of knowledge about one particular chaperone family, that of the HSP70, and highlight their importance, function, and potential co-chaperone interactions. This is then discussed with regard to the suitability of these protein
  • 30/08/2022

    Lipid post-translational modifications mong these PTMs, lipidation plays a unique and key role in subcellular trafficking, signalling and membrane association of proteins through altering substrate function, and hydrophobicity via the addition and removal of lipid groups. Three prevalent class
  • 29/08/2022

    Different types of rosette and the key players involved in rosette formation Since the discovery of rosettes in the late 1980s, different formation mechanisms and pathobiological roles have been postulated for rosetting; most of which have focused on Plasmodium falciparum. Recent breakthroughs, including new data from Plasmodium v
  • 25/08/2022

    The ferredoxin redox system Plasmodium falciparum have shown that the iron sulfur cluster (FeS)-containing ferredoxin is essential in the blood stage parasites, Here we review ferredoxin’s crucial contribution to isoprenoid and lipoate biosynthesis as well as tRNA modification in th
  • 19/08/2022

    Identification of erythrocyte proteins bound to exported P. falciparum proteins we used a biochemical screening approach to identify putative exported P. falciparum proteins that bound to inside-out vesicles prepared from erythrocytes. Out of 69 P. falciparum PEXEL-motif proteins tested, 18 bound to inside-out vesicles (IOVs) in two
  • 13/08/2022

    Model for cAMP and Ca2+ mediated signaling pathways that regulate microneme secretion cAMP as a key regulator that triggers the timely secretion of microneme proteins enabling receptor-engagement and invasion. We demonstrate that exposure of merozoites to a low K+ environment, typical of blood plasma, activates a bicarbonate-sensitive cyto
  • 05/08/2022

    lncRNAs operate by different mechanisms rotozoan parasites encode diverse ncRNA transcripts; however, little is known about their cellular functions. Recent advances in high-throughput "omic" studies identified many novel long ncRNAs (lncRNAs) in apicomplexan parasites, some of which undergo sp
  • 05/08/2022

    Interactions between erythrocyte cytoskeletal and exported P. falciparum proteins. We used a biochemical screening approach to identify putative exported P. falciparum proteins that bound to inside-out vesicles prepared from erythrocytes. Out of 69 P. falciparum PEXEL-motif proteins tested, 18 bound to inside-out vesicles (IOVs) in two
  • 19/07/2022

    Characteristics of known and putative P. falciparum transport proteins manual curation of information from various sources led to the identification of 197 known and putative transporter genes, representing almost 4% of all parasite genes, a proportion that is comparable to well-studied metazoan species. This transporter lis
  • 29/06/2022

    Fast- and slow-acting antimalarials against cultured P. falciparum strains An incisive comprehensive analysis of the fast and slow-acting profile of antimalarial agents relating to parasite time-kill kinetics and the target organelle on the progression of blood-stage parasites was carried out. It is evident from numerous finding