You can find more information about Calcium-dependent protein kinases; CDPK1 using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_0217500

PFB0815w

Calcium-dependent protein kinases; CDPK1

PlasmoDB

TDR

(2-{1,1,5,9-tetraoxo-4H,5H,9H-1λ⁶-[1,4]thiazino[2,3-f]indol-8- yl}ethyl)urea	Computational strategies to explore antimalarial thiazine alkaloid lead compounds based on an Australian marine sponge Plakortis Lita
{4-[2-trans-(4-Amino-cyclohexylamino)-9-(4-ethoxy-phenyl)-9H-purin-6-ylamino]-phenyl}-piperidin-1-yl-methanone	Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
{4-[2-trans-(4-Amino-cyclohexylamino)-9-benzo[1,3]dioxol-5-yl-9H-purin-6-ylamino]-phenyl}-piperidin-1-yl-methanone	Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
{4-[9-(3-Fluoro-phenyl)-2-trans-(4-hydroxy-cyclohexylamino)-9H-purin-6-ylamino]-phenyl}-piperidin-1-yl-methanone	Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
1-(5-(4-amino-1-isobutyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)indolin-1-yl)-2-methylpropan-1-one	Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G
17-N-allylamino-17-demethoxygeldanamycin	Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
2-amino-3-[(4-methylphenyl)carbonyl]indolizine-1-carboxamide	Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1
2-hydroxy-N-(2-{1,1,5,9-tetraoxo-4H,5H,9H-1λ⁶- [1,4]thiazino[2,3-f]indol-8-yl}ethyl)propanamide	Computational strategies to explore antimalarial thiazine alkaloid lead compounds based on an Australian marine sponge Plakortis Lita
2-methoxy-N-(2-{1,1,5,9-tetraoxo-4H,5H,9H-1λ⁶-[1,4]thiazino[2,3- f]indol-8-yl}ethyl)acetamide	Computational strategies to explore antimalarial thiazine alkaloid lead compounds based on an Australian marine sponge Plakortis Lita
2-N-[4-(3,4-Dimethylpiperazin-1-yl)phenyl]- 4-N-(3-methylphenyl)pyrimidine-2,4-diamine	Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors
3-(2-(benzyloxy)quinolin-6-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G
3-(6-ethoxynaphthalen-2-yl)-1-((1-methylpiperidin-4-yl)methyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G
3-(6-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G
3,6-imidazopyridazine	Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)
3-{2-trans-(4-Amino-cyclohexylamino)-6-[4-(piperidine-1-carbonyl)-phenylamino]-purin-9-yl}-benzoic acid	Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
3-{6-[(3-Methylbutyl)amino]pyridin-3-yl}-N-(1-methylpiperidin-4-yl)imidazo[1,2-b]pyridazin-6-amine	Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
3-Chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]benzamide	Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like CDPK1, a multistage growth regulator of P. falciparum
4-[7-[(dimethylamino)-methyl]-2-(4-fluorphenyl)imidazo[1,2-a]pyridine-3-yl] pyrimidin-2-amine	Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion
4-{2-trans-(4-Amino-cyclohexylamino)-6-[4-(piperidine-1-carbonyl)-phenylamino]-purin-9-yl}-benzoic acid	Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
4-N-(3-Methylphenyl)-2-N-[4-(4-methylpiperazin-1-yl) phenyl]pyrimidine-2,4-diamine	Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors
5-amino-1-(2,2-dimethylpropyl)-3-(2-naphthyl)pyrazole-4-carboxamide	5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents
5-amino-3-(6-methoxy-2-naphthyl)-1-methyl-pyrazole-4-carboxamide	5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents
5-amino-3-[2-(cyclobutoxy)-6-quinolyl]-1-isopropyl-pyrazole-4-carboxamide	5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents
Aminoethylpyridine	Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)
Azabenzimidazole	Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1
Dasatinib	Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs
Imidazo[1,2-β]pyridazine	Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1
Imidazopyridazine	Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1
Isoxazole amide	Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1
K252a	The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase
Lestaurtinib	Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs
MV008270	Allosteric regulation of the inactive to active state conformational transition in CDPK1 protein of Plasmodium falciparum
N-[2-(Methylamino)-2-Oxidanylidene-Ethyl]-2-(4-Pyrazol-1-Ylphenyl)-N-(1-Pyridin-2-Ylpiperidin-4-Yl)ethanamide	Targeted Inhibition of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 with a Constrained J Domain-Derived Disruptor Peptide
NA-PP1	Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
Nilotinib	Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs
NM-PP1	Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
Pazopanib	Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs
Plx-4720	Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs
Purfalcamine	Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen 5 triggers merozoite egress
Pyrazinone	Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1
Pyrazolopyrimidine	Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1
Sorafenib	Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs
Staurosporine	Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1 Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs
Sunitinib	Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs
TCMDC-134116	Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors
TCMDC-136676	Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
TCMDC-138389	Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
TCMDC-138435	Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
TCMDC-138446	Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds
trans-N-(3-{2-[(3-Fluoropyridin-2-yl)amino]pyrimidin-5-yl}imidazo[1,2-b]pyridazin-6-yl)cyclohexane-1,4-diamine	Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development
trans-N-{3-[5-Fluoro-6-(pyridin-2-ylamino)pyridin-3-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine	Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

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