You can find more information about histo-aspartic protease using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_1408100

PF14_0078

plasmepsin III histo-aspartic protease

PlasmoDB

TDR

(4R)-N-tert-Butyl-3-[(2S,3S)-2-hydroxy-3-({N-[(isoquinolin-5-yloxy)acetyl]-S-methyl-L-cysteinyl}amino)-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide	High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor
4-(5-(4-methoxyphenyl)- 1’phenyl-3’-(p-tolyl)-3,4- 1’H,2H-[3,4’-bipyrazol]-2- yl)benezenesulfonamide	Molecular docking and dynamics studies on novel benzene sulfonamide substituted pyrazole-pyrazoline analogues as potent inhibitors of Plasmodium falciparum Histo aspartic protease
Alln	Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
Atazanavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
Diphenylurea	Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
Doxorubicin	Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring
E-64	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
Fragment-based docking and consensus scoring, halofantrine, doxorubicin, lumefantrine	Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring
G16	Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites
Halofantrine	Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring
Indinavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
Kni-10006	Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum
Kni-10395	Structural insights into the activation and inhibition of histo-aspartic protease from Plasmodium falciparum
Leupeptin	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
Lopinavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
Lumefantrine	Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring
Nelfinavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
Pepstatin a	Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum Antimalarial activity of thiosemicarbazones and purine derived nitriles Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors Molecular modeling and prediction of binding mode and relative binding affinity of Art-Qui-OH with P. falciparum Histo-Aspartic Protease (HAP)
Purine	Antimalarial activity of thiosemicarbazones and purine derived nitriles
Ritonavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
Ro 40-4388	Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
Saquinavir	Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
Sucralfate	A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast
Suggested target	Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy
X-ray structures and 3d models , suggested target	Predicting functional residues in Plasmodium falciparum plasmepsins by combining sequence and structural analysis with molecular dynamics simulations
ZINC02619047	Unveiling a New Era in Malaria Therapeutics: A Tailored Molecular Approach Towards the Design of Plasmepsin IX Inhibitors

Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System