You can find more information about tRNA aminoacyl synthetases Class I using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_0311200

PFC0470w

valine--tRNA ligase, putative

PlasmoDB

TDR

PF3D7_0622800

PFF1095w

leucine--tRNA ligase, putative

PlasmoDB

TDR

AN6426	Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase
AN8432	Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase
norvaline	Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase

PF3D7_0807900

MAL8P1.125

tyrosine--tRNA ligase

PlasmoDB

TDR

Picture 1

Cefprozil

In silico assessment of natural products and approved drugs as potential inhibitory scaffolds targeting aminoacyl-tRNA synthetases from Plasmodium

PF3D7_0828200

PF08_0011

leucine--tRNA ligase, putative

PlasmoDB

TDR

PF3D7_0913900

PFI0680c

arginine--tRNA ligase, putative

PlasmoDB

TDR

Picture 1

PF3D7_1005000

PF10_0053

methionine--tRNA ligase, putative

PlasmoDB

TDR

Picture 1

5-(5-Phenyl-furan-2-ylmethylene)-2-thioxo-thiazolidin- 4-one	Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases
5-[3-[(6,8-dibromochroman-4-yl)amino]propylamino]-4H-thieno[3,2-b]pyridin-7-one	Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases
5-[3-[[4-bromo-5-(1-fluorovinyl)-3-methyl-tetrahydrothiophen-2-yl]methylamino]propylamino]-4H-thieno[3,2-b]pyridin-7-one	Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases

PF3D7_1015200

PF10_0149

cysteine--tRNA ligase, putative

PlasmoDB

TDR

PF3D7_1034900

PF10_0340

methionine--tRNA ligase

PlasmoDB

TDR

Picture 1

5-[3-[[4-bromo-5-(1-fluorovinyl)-3-methyl-tetrahydrothiophen-2-yl]methylamino]propylamino]-4H-thieno[3,2-b]pyridin-7-one	Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases
N,N'-1,3-benzothiazole-2,6-diyldi(2-furamide)	Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases
Tcmdc-139627	Thousands of chemical starting points for antimalarial lead identification

PF3D7_1117500

PF11_0181

tyrosine--tRNA ligase

PlasmoDB

TDR

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((2R,3S,4R,5S)-5-((R)-4-amino-5-(difluoromethoxy)-7H-cyclopenta[d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl sulfamate	Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy
Tcmdc-141232	Thousands of chemical starting points for antimalarial lead identification

PF3D7_1218600

PFL0900c

arginine-tRNA ligase; arginyl-tRNA synthetase

PlasmoDB

TDR

Hemin	Dimerization of Arginyl-tRNA Synthetase by Free Heme Drives Its Inactivation in Plasmodium falciparum
Metabolic network of knock-out strains in silico, suggested target	Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico
Protoporphyrin ix	Dimerization of Arginyl-tRNA Synthetase by Free Heme Drives Its Inactivation in Plasmodium falciparum
Topology of the metabolic network, suggested target	Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico

PF3D7_1225100

PFL1210w

isoleucine--tRNA ligase, putative

PlasmoDB

TDR

9-{[(2E)-4-(3,4-Dihydroxy-5-{[3-(3-hydroxy-2-butanyl)-2-oxiranyl]methyl}tetrahydro-2H-pyran-2-yl)-3-methyl-2-butenoyl]oxy}nonanoic acid	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Mupirocin	Validation of isoleucine utilization targets in Plasmodium falciparum Using genetic methods to define the targets of compounds with antimalarial activity

PF3D7_1251700

PFL2485c

tryptophanyl-tRNA synthetase, putative tryptophan--tRNA ligase, putative

PlasmoDB

TDR

indolmycin

PF3D7_1331700

PF13_0170

glutamine--tRNA ligase, putative

PlasmoDB

TDR

Picture 1

PF3D7_1332900

PF13_0179

isoleucine--tRNA ligase, putative

PlasmoDB

TDR

2-Amino-3-(methylsulfanyl)butanoic acid	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Tcmdc-131575	Thousands of chemical starting points for antimalarial lead identification
Thiaisoleucine	Validation of isoleucine utilization targets in Plasmodium falciparum

PF3D7_1336900

PF13_0205

tryptophanyl-tRNA synthetase tryptophan--tRNA ligase

PlasmoDB

TDR

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Cassiarin-F	Inverse docking based screening and identification of protein targets for Cassiarin alkaloids against Plasmodium falciparum
Crystal structure transition states, suggested target	Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design

PF3D7_1349200

PF13_0257

glutamate--tRNA ligase, putative

PlasmoDB

TDR

PF3D7_1350100

PF13_0262

lysine--tRNA ligase

PlasmoDB

TDR

(1-benzyl-4-piperidyl)[6,7-dimethoxy-2-(4-methyl-1,4-diazepin-1-yl)-4-quinazolinyl]amine	Antimalarial drug discovery - approaches and progress towards new medicines
(R)-6,8-dihydroxy-3-(((2R,6R)-6-methyltetrahydro-2H-pyran-2-yl)methyl)isochroman-1-one	Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
(R)-6,8-dihydroxy-3-((3-methylpiperidin-1-yl)methyl)-1H-isochromen-1-one	Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via a piperidine-ring scaffold inspired Cladosporin analogues
(R)-6,8-Dihydroxy-3-((R)-hydroxy- ((2R,6S)-6-methyltetrahydro-2H-pyran-2-yl)methyl)- isochroman-1-one	Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites
3-(cyclohexylmethyl)-6,8-dihydroxy-1H-isochromen-1-one	Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin
6,8-dihydroxy-3-((3-methylcyclohexyl)methyl)-1H-isochromen-1-one	Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase
6,8-Dihydroxy-3-[(6-methyltetrahydro-2H-pyran-2-yl)methyl]-3,4-dihydro-1H-isochromen-1-one	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Calcipotriol	In silico assessment of natural products and approved drugs as potential inhibitory scaffolds targeting aminoacyl-tRNA synthetases from Plasmodium
cladosporin	Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin Using genetic methods to define the targets of compounds with antimalarial activity Antimalarial drug discovery - approaches and progress towards new medicines Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor Side chain rotameric changes and backbone dynamics enable specific cladosporin binding in Plasmodium falciparum lysyl-tRNA synthetase
Crystal structure, suggested target	Structural analysis of malaria-parasite lysyl-tRNA synthetase provides a platform for drug development
Decoquinate	Using genetic methods to define the targets of compounds with antimalarial activity
Gene silencing, suggeted target	Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-6-fluoro-4-oxo-4H-chromene-2-carboxamide	Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
N-[2-(Isopropylsulfonyl)phenyl]-N'-{2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}-1,3,5-triazine-2,4-diamine	Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor
Perlolyrine	Metabolomic Profiling, In Vitro Antimalarial Investigation and In Silico Modeling of the Marine Actinobacterium Strain Rhodococcus sp. UR111 Associated with the Soft Coral Nephthea sp

PF3D7_1357200

MAL13P1.281

glutamate--tRNA ligase

PlasmoDB

TDR

5′-o-[n-(l-glutamyl)sulfamoyl]adenosine	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
5-Benzylidene-2-thioxothiazolidin-4-one	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
5-O-[N-(Lglutamyl)sulfamoyl]adenosine	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
Acrisorcin	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
Alvespimycin	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
cladosporin	Structural characterization of Glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum
Gambogic acid	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
Ganetespib	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
Gedunin	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
Harmine	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
Monorden	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
Novobiocin sodium	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
Radicicol	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
Tanespimycin	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway
Vitespen	A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway

PF3D7_1416800

PF14_0166

lysine--tRNA ligase, putative

PlasmoDB

TDR

Picture 1

(2S)-4-[[(2R)-2-amino-3-(2-aminoethylsulfanyl)propanoyl]-hydroxy-amino]-1-[3-(1,3-diphenylpyrazol-4-yl)propanoyl]pyrrolidine-2-carboxamide	Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum
(2S)-4-[[(2R)-2-amino-3-(2-aminoethylsulfanyl)propanoyl]-hydroxy-amino]-1-[5-(m-tolyl)furan-2-carbonyl]pyrrolidine-2-carboxamide;hydroxydiazene	Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum
(2S)-4-[[(2S)-2,6-diaminohexanoyl]-hydroxy-amino]-1-[5-(m-tolyl)furan-2-carbonyl]pyrrolidine-2-carboxamide;hydroxydiazene	Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum
(R)-6,8-dihydroxy-3-(((2R,6R)-6-methyltetrahydro-2H-pyran-2-yl)methyl)isochroman-1-one	Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
cladosporin	Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
Lysyl-adenylate	Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum

PF3D7_1461900

PF14_0589

valine--tRNA ligase, putative

PlasmoDB

TDR

Picture 1

Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System