You can find more information about tRNA aminoacyl synthetases Class II using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_0102900

PFA0145c

aspartate--tRNA ligase

PlasmoDB

TDR

PF3D7_0109800

PFA0480w

phenylalanyl-tRNA synthetase alpha subunit

PlasmoDB

TDR

Picture 1

(7S,8R,9S)-9-(hydroxymethyl)-N-(4-methoxyphenyl)-8-[4-(2-phenylethynyl)phenyl]-1,5-diazabicyclo[5.2.0]nonane-5-carboxamide	Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp 3)-H Arylation
(7S,8S,9R)-9-[2-(dimethylamino)ethyl]-N-(4-methoxyphenyl)-8-[4-(2-phenylethynyl)phenyl]-1,5-diazabicyclo[5.2.0]nonane-5-carboxamide	Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp 3)-H Arylation
(8R,9R,10S)-10-(hydroxymethyl)-N-(4-methoxyphenyl)-9-(4-(phenylethynyl)phenyl)-1,6- diazabicyclo[6.2.0]decane-6-carboxamide	Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
(8R,9R,10S)-10-(hydroxymethyl)-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide	Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
(8R,9S,10S)-10-((dimethylamino)methyl)-N-(4-methoxyphenyl)-9-(4- (phenylethynyl)phenyl)-1,6-diazabicyclo[6.2.0]decane-6-carboxamide	Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
(8R,9S,10S)-10-(aminomethyl)-N-(4-methoxyphenyl)-9-(4-(phenylethynyl)phenyl)-1,6- diazabicyclo[6.2.0]decane-6-carboxamide	Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
(8R,9S,10S)-10-(aminomethyl)-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
(8R,9S,10S)-10-[(dimethylamino)methyl]-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide	Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
In silico prediction of protein targets of antimalarial compounds, suggested target	Prediction of the P. falciparum target space relevant to malaria drug discovery
Tcmdc-140563	Thousands of chemical starting points for antimalarial lead identification

PF3D7_0211800

PFB0525w

asparagine--tRNA ligase

PlasmoDB

TDR

PF3D7_0416100

PFD0780w

glutamyl-tRNA(Gln) amidotransferase subunit A

PlasmoDB

TDR

Picture 1

6-diazo-5-oxonorleucine

Computational and experimental analysis identified 6-diazo-5-oxonorleucine as a potential agent for treating infection by Plasmodium falciparum

PF3D7_0509600

PFE0475w

asparagine--tRNA ligase

PlasmoDB

TDR

Picture 1

PF3D7_0514300

PFE0715w

aspartate--tRNA ligase, putative

PlasmoDB

TDR

PF3D7_0603700

PFF0180w

phenylalanine--tRNA ligase

PlasmoDB

TDR

Picture 1

Gallinamide a

Plasmodium falciparum mitochondria import tRNAs along with an active phenylalanyl-tRNA synthetase

PF3D7_0628800

PFF1395c

glutamyl-tRNA(Gln) amidotransferase subunit B, putative

PlasmoDB

TDR

Picture 1

PF3D7_0717700

PF07_0073

serine--tRNA ligase, putative

PlasmoDB

TDR

Picture 1

PF3D7_0925300

PFI1240c

proline--tRNA ligase, putative

PlasmoDB

TDR

Picture 1

aplysulphurin-1	Identification of Selective Novel Hits against Plasmodium falciparum Prolyl tRNA Synthetase Active Site and a Predicted Allosteric Site Using in silico Approaches
glyburide	Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
Halofuginone	Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase
TCMDC-124506	Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

PF3D7_0934000

PFI1645c

histidine--tRNA ligase, putative

PlasmoDB

TDR

PF3D7_1104000

PF11_0051

phenylalanine--tRNA ligase beta subunit

PlasmoDB

TDR

(3S,4R,8R,9R)-N-(4-cyclopropoxyphenyl)-3,4-dihydroxy-10-(methoxymethyl)-9-(4-(phenylethynyl)phenyl)-1,6-diazabicyclo[6.2.0]decane-6-carboxamide

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

PF3D7_1126000

PF11_0270

threonine--tRNA ligase

PlasmoDB

TDR

Borrelidin	A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Bufexamac	Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo
Chloroquine	Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase

PF3D7_1213800

PFL0670c

prolyl-tRNA synthetase proline--tRNA ligase

PlasmoDB

TDR

Picture 1

3-(cyclohexanecarboxamido)-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide	Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance
4-((1H-indol-3-yl)methyl)-1-butyl-1,2-dihydro-6H-pyrazino[2,1-b]quinazoline-3,6(4H)-dione	Indole-Containing Pyrazino[2,1- b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids
epi-febrifuginol	Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Febrifugine	Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
febrifuginol	Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Halofuginol	The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs
Halofuginone	Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Ncgc00015280	Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis
Protein biology suggested target	Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis
Raltitrexed	In silico assessment of natural products and approved drugs as potential inhibitory scaffolds targeting aminoacyl-tRNA synthetases from Plasmodium

PF3D7_1216000

PFL0770w

serine--tRNA ligase, putative

PlasmoDB

TDR

PF3D7_1232000

PFL1540c

phenylalanine--tRNA ligase

PlasmoDB

TDR

Picture 1

PF3D7_1313200

MAL13P1.67

methionyl-tRNA formyltransferase, putative

PlasmoDB

TDR

Metabolic network of knock-out strains in silico, suggested target	Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico
Topology of the metabolic network, suggested target	Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico

PF3D7_1367700

PF13_0354

alanine--tRNA ligase

PlasmoDB

TDR

PF3D7_1420400

PF14_0198

glycine--tRNA ligase

PlasmoDB

TDR

PF3D7_1445100

PF14_0428

histidine--tRNA ligase, putative

PlasmoDB

TDR

Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System