You can find more information about protein farnesyltransferase subunit beta using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_1147500

PF11_0483

protein farnesyltransferase subunit beta

PlasmoDB

TDR

1-methyl-1h-imidazole-4-sulfonamide not (4-bromo and 4-phenyl derivatives)	Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites
2-(aminoacylamino)benzophenones	2-(aminoacylamino)benzophenones: farnesyltransferase inhibition and antimalarial activity
2-(arylacryloylamino)	2-(Arylpropionylamino)- and 2-(arylacryloylamino)benzophenones: farnesyltransferase inhibition and antimalarial activity
2-(arylpropionylamino)	2-(Arylpropionylamino)- and 2-(arylacryloylamino)benzophenones: farnesyltransferase inhibition and antimalarial activity
2,5-diaminobenzophenone	Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties 3D-QSAR analysis of antimalarial farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold
2-oxo-tetrahydro-1,8-naphthyridines	2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials
2-oxotetrahydroquinoline	2-Oxotetrahydroquinoline-based antimalarials with high potency and metabolic stability
3-arylthiophene 2-carboxylic acids	New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis
4-Metoxychalcone	Protein farnesyltransferase inhibitors exhibit potent antimalarial activity Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials 2D Chemometrics analyses of tetrahydroquinoline and ethylenediamine derivatives with antimalarial activity
5-arylacryloylaminobenzophenone	Inhibitors of farnesyltransferase: 5-arylacryloylaminobenzophenones show antimalarial activity
6-cyano-1-(3-methyl-3h-imidazoly-4-ylmethyl)-3-substituted-1,2,3,4-tetrahydroquinoline	QSAR study on tetrahydroquinoline analogues as plasmodium protein farnesyltransferase inhibitors: a comparison of rationales of malarial and mammalian enzyme inhibitory activities for selectivity
Acryloylaminobenzophenone	Structure-activity relationships of novel anti-malarial agents part 8. Effect of different central aryls in biarylacryloylaminobenzophenones on antimalarial activity
Alisiaquinol	Alisiaquinones and alisiaquinol, dual inhibitors of Plasmodium falciparum enzyme targets from a New Caledonian deep water sponge
Alisiaquinone A	Alisiaquinones and alisiaquinol, dual inhibitors of Plasmodium falciparum enzyme targets from a New Caledonian deep water sponge
Alisiaquinone B	Alisiaquinones and alisiaquinol, dual inhibitors of Plasmodium falciparum enzyme targets from a New Caledonian deep water sponge
Alisiaquinone C	Alisiaquinones and alisiaquinol, dual inhibitors of Plasmodium falciparum enzyme targets from a New Caledonian deep water sponge
Benzophenone	Farnesyltransferase inhibitors inhibit the growth of malaria parasites in vitro and in vivo
Benzophenone	Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials
Bms-339941	Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase
Bms-388891	Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase
Cvfm	Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents
Ethylenediamine	Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents 2D Chemometrics analyses of tetrahydroquinoline and ethylenediamine derivatives with antimalarial activity
Farnesylpyrophosphate	Towards the synthesis of bisubstrate inhibitors of protein farnesyltransferase: Synthesis and biological evaluation of new farnesylpyrophosphate analogues
Fti	In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
Furylacrylic acid	Structure-activity relationships of novel anti-malarial agents: part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides
Methylpiperazinyl	Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials
N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides	Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity
N-(4-arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)- 2-furyl]acrylic acid amides	Structure-activity relationships of novel anti-malarial agents. Part 6: N-(4-arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides
N-(4-piperidinyl)benzamide	Novel N-(4-Piperidinyl)benzamide antimalarials with mammalian protein farnesyltransferase inhibitory activity
N,n,n’-trimethylethylenediamine	Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials
N-[(5-{[(2R)-2-Amino-3-sulfanylpropyl]amino}-2-biphenylyl)carbonyl]-L-methionine	Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis
N-[(5-{[(2R)-2-Amino-3-sulfanylpropyl]amino}-2-biphenylyl)carbonyl]-L-methionine	Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis
Risedronate	In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity
Zoledronate	Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

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