You can find more information about
Gyrase
using the following links:
PFID
PFID Old
Formal Annotation
PlasmoDB
TDR Targets
Subcellular Localization
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
PF3D7_1223300
PFL1120c
DNA gyrase subunit A
PlasmoDB
TDR
Picture 1
3,6-diamino-10- methylacridinum chloride
Potent antimalarial activity of acriflavine in vitro and in vivo
3,6-diaminoacridine
Potent antimalarial activity of acriflavine in vitro and in vivo
Biochemical analyses, suggested target
Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA
ciprofloxacin
Nuclear gyrB encodes a functional subunit of the Plasmodium falciparum gyrase that is involved in apicoplast DNA replication
Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach
Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons
Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites
ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylate
Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach
ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylate;ferrocene
Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach
ethyl 6-fluoro-1-methyl-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylate;ferrocene
Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach
etoposide
Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons
Fluoroquinolone
Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach
Quinolone
A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast
Ribozyme rz491gyra
Ribozyme cleavage of Plasmodium falciparum gyrase A gene transcript affects the parasite growth
Suggested target
Molecular cloning of apicoplast-targeted Plasmodium falciparum DNA gyrase genes: unique intrinsic ATPase activity and ATP-independent dimerization of PfGyrB subunit
Tcmdc-134527
Thousands of chemical starting points for antimalarial lead identification
PF3D7_1239500
PFL1915w
DNA gyrase subunit B
PlasmoDB
TDR
Picture 1
(3,9,10,11-tetrahydroxybicyclo[5.4.0]undeca 1(7),3,5,8,10-pentaen-2-one
Inhibitory compounds targeting Plasmodium falciparum Gyrase B
fosmidomycin
Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons
N,n-dimethyl aminopropylamine
Synthesis and bio-evaluation of alkylaminoaryl phenyl cyclopropyl methanones as antitubercular and antimalarial agents
Novobiocin
Nuclear gyrB encodes a functional subunit of the Plasmodium falciparum gyrase that is involved in apicoplast DNA replication
Pyridinium
Potent antimalarial activity of acriflavine in vitro and in vivo
Tcmdc-134527
Thousands of chemical starting points for antimalarial lead identification
Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System