You can find more information about DNA gyrase subunit A using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_1223300

PFL1120c

DNA gyrase subunit A

Picture 1

3,6-diamino-10- methylacridinum chloride	Potent antimalarial activity of acriflavine in vitro and in vivo
3,6-diaminoacridine	Potent antimalarial activity of acriflavine in vitro and in vivo
Biochemical analyses, suggested target	Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA
ciprofloxacin	Nuclear gyrB encodes a functional subunit of the Plasmodium falciparum gyrase that is involved in apicoplast DNA replication Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites
ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylate	Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach
ethyl 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylate;ferrocene	Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach
ethyl 6-fluoro-1-methyl-4-oxo-7-piperazin-1-yl-quinoline-3-carboxylate;ferrocene	Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach
etoposide	Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons
Fluoroquinolone	Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach
Quinolone	A systematic in silico search for target similarity identifies several approved drugs with potential activity against the Plasmodium falciparum apicoplast
Ribozyme rz491gyra	Ribozyme cleavage of Plasmodium falciparum gyrase A gene transcript affects the parasite growth
Suggested target	Molecular cloning of apicoplast-targeted Plasmodium falciparum DNA gyrase genes: unique intrinsic ATPase activity and ATP-independent dimerization of PfGyrB subunit
Tcmdc-134527	Thousands of chemical starting points for antimalarial lead identification

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