You can find more information about
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
using the following links:
PFID
PFID Old
Formal Annotation
PlasmoDB
TDR Targets
Subcellular Localization
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
PF3D7_0209300
PFB0420w
2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
PlasmoDB
TDR
2C-methyl-d-erythritol 2,4-cyclodiphosphate
Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy
Biochemical characterization, suggested target
Biosynthesis of terpenoids. 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF) from Plasmodium falciparum
Crystal structure, suggested target
Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development
Metabolic control analysis and in silico inhibition studies, ketoclomazone
Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum
Metabolic network analysis, suggested target
Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis
N,N'-(4,5-Dibromo-1,2-phenylene)bis(4-bromobenzenesulfonamide)
Aryl Bis-Sulfonamide Inhibitors of IspF from Arabidopsis thaliana and Plasmodium falciparum
N,N'-(4,5-Dinitro-1,2-phenylene)bis(4-methylbenzenesulfonamide)
Aryl Bis-Sulfonamide Inhibitors of IspF from Arabidopsis thaliana and Plasmodium falciparum
Suggested target
Biosynthesis of isoprenoids: a bifunctional IspDF enzyme from Campylobacter jejuni
Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment
Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System
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