You can find more information about Lysine-tRNA ligase using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_1350100

PF13_0262

lysine--tRNA ligase

(1-benzyl-4-piperidyl)[6,7-dimethoxy-2-(4-methyl-1,4-diazepin-1-yl)-4-quinazolinyl]amine	Antimalarial drug discovery - approaches and progress towards new medicines
(R)-6,8-dihydroxy-3-(((2R,6R)-6-methyltetrahydro-2H-pyran-2-yl)methyl)isochroman-1-one	Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
(R)-6,8-dihydroxy-3-((3-methylpiperidin-1-yl)methyl)-1H-isochromen-1-one	Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via a piperidine-ring scaffold inspired Cladosporin analogues
(R)-6,8-Dihydroxy-3-((R)-hydroxy- ((2R,6S)-6-methyltetrahydro-2H-pyran-2-yl)methyl)- isochroman-1-one	Design, Synthesis, and Structural Analysis of Cladosporin-Based Inhibitors of Malaria Parasites
3-(cyclohexylmethyl)-6,8-dihydroxy-1H-isochromen-1-one	Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin
6,8-dihydroxy-3-((3-methylcyclohexyl)methyl)-1H-isochromen-1-one	Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase
6,8-Dihydroxy-3-[(6-methyltetrahydro-2H-pyran-2-yl)methyl]-3,4-dihydro-1H-isochromen-1-one	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Calcipotriol	In silico assessment of natural products and approved drugs as potential inhibitory scaffolds targeting aminoacyl-tRNA synthetases from Plasmodium
cladosporin	Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin Using genetic methods to define the targets of compounds with antimalarial activity Antimalarial drug discovery - approaches and progress towards new medicines Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor Side chain rotameric changes and backbone dynamics enable specific cladosporin binding in Plasmodium falciparum lysyl-tRNA synthetase
Crystal structure, suggested target	Structural analysis of malaria-parasite lysyl-tRNA synthetase provides a platform for drug development
Decoquinate	Using genetic methods to define the targets of compounds with antimalarial activity
Gene silencing, suggeted target	Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-6-fluoro-4-oxo-4H-chromene-2-carboxamide	Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
N-[2-(Isopropylsulfonyl)phenyl]-N'-{2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl}-1,3,5-triazine-2,4-diamine	Inhibition of Plasmodium falciparum Lysyl-tRNA synthetase via an anaplastic lymphoma kinase inhibitor
Perlolyrine	Metabolomic Profiling, In Vitro Antimalarial Investigation and In Silico Modeling of the Marine Actinobacterium Strain Rhodococcus sp. UR111 Associated with the Soft Coral Nephthea sp

PF3D7_1416800

PF14_0166

lysine--tRNA ligase, putative

Picture 1

(2S)-4-[[(2R)-2-amino-3-(2-aminoethylsulfanyl)propanoyl]-hydroxy-amino]-1-[3-(1,3-diphenylpyrazol-4-yl)propanoyl]pyrrolidine-2-carboxamide	Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum
(2S)-4-[[(2R)-2-amino-3-(2-aminoethylsulfanyl)propanoyl]-hydroxy-amino]-1-[5-(m-tolyl)furan-2-carbonyl]pyrrolidine-2-carboxamide;hydroxydiazene	Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum
(2S)-4-[[(2S)-2,6-diaminohexanoyl]-hydroxy-amino]-1-[5-(m-tolyl)furan-2-carbonyl]pyrrolidine-2-carboxamide;hydroxydiazene	Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum
(R)-6,8-dihydroxy-3-(((2R,6R)-6-methyltetrahydro-2H-pyran-2-yl)methyl)isochroman-1-one	Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite
cladosporin	Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
Lysyl-adenylate	Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum

Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System