You can find more information about 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_0106900

PFA0340w

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, putative

(1R,3S)-1-(2,4-dichlorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid	Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target
(5S)-D-methylerythritol monofluoromethyl phosphonate	Synthesis and Evaluation of Fluoroalkyl Phosphonyl Analogues of 2- C-Methylerythritol Phosphate as Substrates and Inhibitors of IspD from Human Pathogens
1-(2,4-Dichlorophenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
2-[3-(4-chlorophenyl)phenyl]-1,2-benzothiazol-3-one	Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD
2-[3-(4-methoxyphenyl)phenyl]-1,2-benzothiazol-3-one	Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD
2-[3-[4-(trifluoromethyl)phenyl]phenyl]-1,2-benzothiazol-3-one	Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD
5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid	Targeting the IspD enzyme in the MEP pathway: identification of a novel fragment class
Differences from host cell orthologue, suggested target	In silico elucidation and inhibition studies of selected phytoligands against Mitogen activated protein kinases of protozoan parasites
Domiphen Bromide	Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway
fosmidomycin	The methylerythritol phosphate pathway is functionally active in all intraerythrocytic stages of Plasmodium falciparum A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling Plasmodium IspD (2-C-Methyl-D-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target
O-((1R)-1-(3,4-dichlorophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carbonyl)-N-methylhydroxylamine	Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs
Pyrrolopyrazines	Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents
X-ray diffraction, suggested target	A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis

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