You can find more information about Complex III using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_0622600

PFF1085a

cytochrome b-c1 complex subunit 9, putative

PlasmoDB

TDR

2-Methyl-3-(4-(4-(Trifluoromethoxy)Phenoxy)Phenyl)- 5,6,7,8-Tetrahydroquinolin-4-One	Potent Tetrahydroquinolone Eliminates Apicomplexan Parasites
3-Chloro-6-(hydroxymethyl)-2-methyl-5-{4-[4-(trifluoromethoxy)phenoxy]phenyl}-4(1H)-pyridinone	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
5,7-difluoro-2-methyl-3-(4-(4-(trifluoromethoxy)phenoxy)phenyl)quinolin-4(1H)-one	The antimalarial compound ELQ-400 is an unusual inhibitor of the bc 1 complex, targeting both Q o and Q i sites
6-(4-Fluorophenyl)-6H-benzo[b]indeno[1,2-e][1,4]thiazepin-5-ol	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Atovaquone	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Cycloguanil	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Decoquinate	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery

PF3D7_1012300

PF10_0120

cytochrome b-c1 complex subunit 7, putative

PlasmoDB

TDR

[4-[(3-hydroxy-1,4-dioxo-2-naphthyl)methyl]phenyl]azinate	Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling
1-hydroxy-2-dodecyl-4(1h)quinolone	HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex
1-hydroxy-2-dodecyl-4(1H)quinolone)	Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages
2-[3-[di(cyclohexa-2,4-dien-1-yl)-phenyl-$l^5-phosphanyl]propoxy]-3-(4-methoxyphenyl)naphthalene-1,4-dione	1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues
2-hydroxy-3-[(4-methoxyphenyl)sulfanyl-(4-nitrophenyl)methyl]naphthalene-1,4-dione	Insights into cytochrome bc1 complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling
2-methyl-3-[3-(1-pyridyl)propoxy]naphthalene-1,4-dione	1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues
2-methyl-3-[3-(3H-pyrrol-1-yl)propoxy]naphthalene-1,4-dione	1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues
2-methyl-4(1h)-quinolones	Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity
4-(1h)-quinolone-3-diarylethers	Quinolone-3-diarylethers: a new class of antimalarial drug
4-oxo-piperidine-3-mono-carboxylate	Quinolone-3-diarylethers: a new class of antimalarial drug
5,7-difluoro-2-methyl-3-octylquinolin-4(1H)-one	Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc 1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis
5-fluoroorotate	A drug-selected Plasmodium falciparum lacking the need for conventional electron transport
6-chloro-7-methoxy-2-methyl-3-[4-[4-(trifluoromethoxy)phenoxy]phenyl]-1H-quinolin-4-one	Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum
6-nh2ac	A drug-selected Plasmodium falciparum lacking the need for conventional electron transport
Acridine	Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex
Antimycin a	A drug-selected Plasmodium falciparum lacking the need for conventional electron transport Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
Atovaquone	Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site Mitochondrial oxygen consumption in asexual and sexual blood stages of the human malarial parasite, Plasmodium falciparum Molecular basis for atovaquone binding to the cytochrome bc1 complex Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae A drug-selected Plasmodium falciparum lacking the need for conventional electron transport Synthesis and antimalarial activity of new atovaquone derivatives Reconstructing the Qo site of Plasmodium falciparum bc 1 complex in the yeast enzyme Computationally designed atovaquone prodrugs based on Bruice's enzyme model Antimalarial drug discovery - approaches and progress towards new medicines Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism Antimalarial drug resistance: new treatments options for Plasmodium Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum Inhibition Mechanism of Antimalarial Drugs Targeting the Cytochrome bc 1 Complex
Benzothiazepines	Using genetic methods to define the targets of compounds with antimalarial activity
Bestatin	Identification of MMV Malaria Box inhibitors of Perkinsus marinus using an ATP-based bioluminescence assay
Chloroquine	Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum
Ciclopirox	Quinolone-3-diarylethers: a new class of antimalarial drug
CK-2-68	Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stages
Clopidol	A drug-selected Plasmodium falciparum lacking the need for conventional electron transport
Compound-x	Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex
Decoquinate	A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor
Dihydroacridinediones	Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex
Elq-300	Antimalarial drug discovery - approaches and progress towards new medicines Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
ethyl 4-hydroxy-5-methylquinoline-3-carboxylate	Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity
ethyl 4-oxo-7-methylquinoline-3-carboxylate	Quinolone-Hydroxyquinoline Tautomerism in Quinolone 3-Esters. Preserving the 4-Oxoquinoline Structure To Retain Antimalarial Activity
F1386-0209	Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits
fosmidomycin	Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum
Gsk932121	Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1 Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1
Gw844520	Preclinical drug metabolism and pharmacokinetic evaluation of GW844520, a novel anti-malarial mitochondrial electron transport inhibitor Identification of new antimalarial leads by use of virtual screening against cytochrome bc1 Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1
Hydroxynaphthoquinone	Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinones
In silico screening and in vitro tests	Identification of new antimalarial leads by use of virtual screening against cytochrome bc1
Licochalcone a	Parasite mitochondria as a target of chemotherapy: inhibitory effect of licochalcone A on the Plasmodium falciparum respiratory chain
Mimosine	Quinolone-3-diarylethers: a new class of antimalarial drug
MMV006309	The relative rate of kill of the MMV Malaria Box compounds provides links to the mode of antimalarial action and highlights scaffolds of medicinal chemistry interest
Myxothiazol	Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways
Napthoquinone	Prediction of the P. falciparum target space relevant to malaria drug discovery
N-butyloxycarbonyloxymethyl	Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum
N-cyclopropyl-5-[(4-methylphenyl)methylsulfanylmethyl]furan-2-carboxamide	An exclusive computational insight toward molecular mechanism of MMV007571, a multitarget inhibitor of Plasmodium falciparum
P218	Antimalarial drug discovery - approaches and progress towards new medicines
Proguanil	Antimalarial drug discovery - approaches and progress towards new medicines
Stigmatellin	A drug-selected Plasmodium falciparum lacking the need for conventional electron transport
tamoxifen	Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1
TCMDC-124971	Discovery of Dual-Stage Malaria Inhibitors with New Targets
TCMDC-135546	Discovery of Dual-Stage Malaria Inhibitors with New Targets
Toslab 802803	Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits
Triclosan	Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1
Wr243251	A drug-selected Plasmodium falciparum lacking the need for conventional electron transport

PF3D7_1426900

PF14_0248

cytochrome b-c1 complex subunit 6, putative

PlasmoDB

TDR

(Z)-2-benzylidene-4,6-dimethoxyindolin-3-one	3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents
Atovaquone	Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials

PF3D7_1439400

PF14_0373

cytochrome b-c1 complex subunit Rieske, putative

PlasmoDB

TDR

2-OH-3-(2-methyl-trifluorooctyl)-naphthoquinone (N	Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance
4-amino-2-(4- methoxyphenyl)isoindoline-1,3-dione	Phthalimide Derivatives with Bioactivity against Plasmodium falciparum: Synthesis, Evaluation, and Computational Studies Involving bc 1 Cytochrome Inhibition
Atovaquone	Hemozoin-free Plasmodium falciparum mitochondria for physiological and drug susceptibility studies

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