You can find more information about
Phe-tRNA ligase
using the following links:
PFID
PFID Old
Formal Annotation
PlasmoDB
TDR Targets
Subcellular Localization
Affecting Drugs
Drug Name
PubMed Articles (year of publication)
PF3D7_0109800
PFA0480w
phenylalanyl-tRNA synthetase alpha subunit
PlasmoDB
TDR
Picture 1
(7S,8R,9S)-9-(hydroxymethyl)-N-(4-methoxyphenyl)-8-[4-(2-phenylethynyl)phenyl]-1,5-diazabicyclo[5.2.0]nonane-5-carboxamide
Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp 3)-H Arylation
(7S,8S,9R)-9-[2-(dimethylamino)ethyl]-N-(4-methoxyphenyl)-8-[4-(2-phenylethynyl)phenyl]-1,5-diazabicyclo[5.2.0]nonane-5-carboxamide
Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp 3)-H Arylation
(8R,9R,10S)-10-(hydroxymethyl)-N-(4-methoxyphenyl)-9-(4-(phenylethynyl)phenyl)-1,6- diazabicyclo[6.2.0]decane-6-carboxamide
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
(8R,9R,10S)-10-(hydroxymethyl)-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
(8R,9S,10S)-10-((dimethylamino)methyl)-N-(4-methoxyphenyl)-9-(4- (phenylethynyl)phenyl)-1,6-diazabicyclo[6.2.0]decane-6-carboxamide
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
(8R,9S,10S)-10-(aminomethyl)-N-(4-methoxyphenyl)-9-(4-(phenylethynyl)phenyl)-1,6- diazabicyclo[6.2.0]decane-6-carboxamide
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
(8R,9S,10S)-10-(aminomethyl)-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide
Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
(8R,9S,10S)-10-[(dimethylamino)methyl]-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
In silico prediction of protein targets of antimalarial compounds, suggested target
Prediction of the P. falciparum target space relevant to malaria drug discovery
Tcmdc-140563
Thousands of chemical starting points for antimalarial lead identification
PF3D7_1104000
PF11_0051
phenylalanine--tRNA ligase beta subunit
PlasmoDB
TDR
Picture 1
Picture 2
(3S,4R,8R,9R)-N-(4-cyclopropoxyphenyl)-3,4-dihydroxy-10-(methoxymethyl)-9-(4-(phenylethynyl)phenyl)-1,6-diazabicyclo[6.2.0]decane-6-carboxamide
Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines
Expasy - NiceZime View
Brenda - The Comprehensive Enzyme Information System