You can find more information about FT using the following links:

PFID

PFID Old

Formal Annotation

PlasmoDB

TDR Targets

Subcellular Localization

Affecting Drugs

Drug Name

PubMed Articles (year of publication)

PF3D7_1147400

PF11_0483a

protein farnesyltransferase subunit beta

PlasmoDB

TDR

Picture 1

(E)-2-(4,8-Dimethylnona-3,7-dien-1-yl)anthracene-9,10- dione	Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors
(E)-6-(2,6-Dimethylhepta-1,5-dien-1-yl)-15-methyl-15-(4- methylpent-3-en-1-yl)benzo[h]naphtho[2,3-c]pyrano[3,2-f] chromene-7,12(6H,15H)-dione	Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors
(E)-N-[3-benzoyl-4-[[2-(p-tolyl)acetyl]amino]phenyl]-3-(4-propoxyphenyl)prop-2-enamide	3D-QSAR analysis of antimalarial farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold
(E)-N-[3-benzoyl-4-[[2-(p-tolyl)acetyl]amino]phenyl]-3-[5-(4-methylsulfonylphenyl)-2-furyl]prop-2-enamide	3D-QSAR analysis of antimalarial farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold
(E)-N-[3-benzoyl-4-[[2-[4-(trifluoromethyl)phenyl]acetyl]amino]phenyl]-3-[5-(4-nitrophenyl)-2-furyl]prop-2-enamide	3D-QSAR analysis of antimalarial farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold
[4-[5-[(1E)-3-[3-benzoyl-4-[3-(3-bromophenyl)propanoylamino]anilino]buta-1,3-dienyl]-2-furyl]phenyl] nitrate	Structure-activity relationships of novel anti-malarial agents: part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides
1-[3-[(3-acetyl-2,4-dihydroxy-5-isopentyl-6-methoxy-phenyl)methyl]-2,6-dihydroxy-5-isopentyl-4-methoxy-phenyl]ethanone	Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes Mediate Merozoite Binding to Human Erythrocytes
2-(4-Methylpent-3-en-1-yl)anthracene-9,10-dione	Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors
2,20 -Bis((E)-4,8-dimethylnona-3,7-dien-1-yl)-2,20 - dimethyl-2H,20 H-[5,50 -bibenzo[h]chromene]-6,60 -diol	Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors
2,7-Bis((E)-4,8-dimethylnona-3,7-dien-1-yl)-2,7- dimethyl-2,7-dihydrobenzo[h]pyrano[3,2-f]chromene	Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors
3-(2,4-Dioxo-1,4-dihydrothieno[3,2-d]pyrimidin-3(2H)-yl)-N-(2-methoxybenzyl)propanamide	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Biochemical characterization, suggested target	Structure-based binding between protein farnesyl transferase and PRL-PTP of malaria parasite: an interaction study of prenylation process in Plasmodium
BMS-214662	QSAR study on tetrahydroquinoline analogues as plasmodium protein farnesyltransferase inhibitors: a comparison of rationales of malarial and mammalian enzyme inhibitory activities for selectivity
BMS-386914	The Prenylated Proteome of Plasmodium falciparum Reveals Pathogen-specific Prenylation Activity and Drug Mechanism-of-action
Mallotojaponin B	Mallotojaponins B and C: Total Synthesis, Antiparasitic Evaluation, and Preliminary SAR Studies
Mallotojaponin C	Mallotojaponins B and C: Total Synthesis, Antiparasitic Evaluation, and Preliminary SAR Studies
N-{6-Cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydro-3-quinolinyl}-1-methyl-N-(2-methyl-2-propen-1-yl)-1H-imidazole-4-sulfonamide	Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery
Tecomaquinone	Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors
Tectol	Discovery and preliminary structure-activity relationship studies on tecomaquinone I and tectol as novel farnesyltransferase and plasmodial inhibitors

PF3D7_1242600

PFL2050w

protein farnesyltransferase subunit alpha

PlasmoDB

TDR

BMS-386914

The Prenylated Proteome of Plasmodium falciparum Reveals Pathogen-specific Prenylation Activity and Drug Mechanism-of-action