You can find more information about M1-family alanyl aminopeptidase using the following links:

PlasmoDB - the Plasmodium genome resource
The TDR Targets Database

Subcellular Localization

PDB protein strucure

Affecting Drugs
Drug Name PubMed Articles (year of publication)
((4-(1H-Pyrazol-1-yl)phenyl)(amino)methyl)phosphonic acid
(5S)-2-amino-5-[[(2S)-2-amino-2-phenyl-acetyl]-[2-anilino-1-(2-furyl)-2-oxo-ethyl]amino]-6-hydroxy-6-lambda3-oxidanylidyne-4-methyl-hexanoic acid
(Z)-2-(hydroxycarbamoyl)-3-phenyl-N-(4-phenylbutyl)prop-2-enamide
(Z)-N-[(4-fluorophenyl)methyl]-2-(hydroxycarbamoyl)-3-phenyl-prop-2-enamide
2-(2-(Bicyclo[2.2.1]heptan-2-yl)acetamido)-N-hydroxy-2-(3',4',5'-trifluoro-[1,1'-biphenyl]- 4-yl)acetamide
2-(4-bromophenyl)-2-(butoxymethylamino)ethanehydroxamic acid
2-(butoxymethylamino)-2-[4-(2,4,6-trifluorocyclohexa-2,4-dien-1-yl)phenyl]ethanehydroxamic acid
2-(hydroxycarbamoyl)-N-(1-naphthylmethyl)pentanamide
2-(hydroxycarbamoyl)-N-[(5-phenoxycyclohexa-1,3-dien-1-yl)methyl]pentanamide
2-[[(1-amino-3-phenyl-propyl)-hydroxy-phosphoryl]methyl]-3-(4-hydroxyphenyl)propanoic acid
2-[[(1-Amino-4-phenylbutyl)hydroxyphosphinyl]-methyl]-3-(4-hydroxyphenyl)propionic Acid
2-[[(1-Amino-4-phenylbutyl)hydroxyphosphinyl]-methyl]-3-phenylpropionic Acid
2-amino-1-hydroxyphosphonates
2-amino-N-[3-[4-[3-[(7-chloro-4-quinolyl)amino]propyl]piperazin-1-yl]propyl]-3-(hydroxyamino)-N-isobutyl-3-oxo-propanamide
2-benzyl-3-(hydroxyamino)-3-oxo-N-(4-phenylbutyl)propanamide
2-benzyl-3-(hydroxyamino)-N-(o-tolylmethyl)-3-oxo-propanamide
2-benzyl-N-[(4-fluorophenyl)methyl]-3-(hydroxyamino)-3-oxo-propanamide
2-benzyl-N1-(4-fluorobenzyl)-N3-hydroxymalonamide
7-amino-4-phenyl-5,7,8,9-tetrahydro-6H-benzo[7]annulen-6-one
7-amino-5,7,8,9-tetrahydro-6H-benzo[7]annulen-6-one
Alpha-aminoalkylphosphonates
Amastatin
and N-(1-(4-(1H-pyrazol-1-yl)phenyl)-2-(hydroxyamino)-2-oxoethyl)pivalamide
Arginine fosfomycin
Atovaquone
Bdm14471
Benzyl alcohol
Bestatin
Bestatin methyl ester
Chloroquine
Chr-2863
Chr-6768
Deferoxamine
E-64
Epiamastatin
Fbs0701
GNF-Pf-2389
GNF-Pf-2795
GNF-Pf-3024
GNF-Pf-3139
GNF-Pf-3890
GNF-Pf-4269
GNF-Pf-5492
Hydroxamate
Malonic acid
MMV007228
MMV007273
MMV019241
MMV020750
MMV084434
Mmv403679
MMV665969
MMV666022
Mmv666023
MMV666054
N-(2-(hydroxyamino)-2-oxo-1-(4-(3,4,5-trifluorocyclohexyl)phenyl)ethyl)-3-methylbutanamide
N-[(2S,3R)-3-AMINO-2-HYDROXY-4-(4-METHOXYPHENYL) BUTANOYL]-L-LEUCINE
N-[3-[4-[3-[(7-chloro-4-quinolyl)amino]propyl]piperazin-1-yl]propyl]-2-(hydroxycarbamoyl)-N-isobutyl-4-methyl-pentanamide
N-[3-[4-[3-[(7-chloro-4-quinolyl)amino]propyl]piperazin-1-yl]propyl]-3-(hydroxyamino)-N-isobutyl-3-oxo-propanamide
Nitrobestatin
Pepstatin
Peptide r1
Phosphinate
Pro-arg-fluoromethyl ketone
sMD simulation
Substrate specificty suggested target
tert-butyl (1-(4-(1H-pyrazol-1-yl)phenyl)-2-(hydroxyamino)-2-oxoethyl)carbamate
tert-butyl N-[1-(4-bromophenyl)-2-(hydroxyamino)-2-oxo-ethyl]carbamate
Tosedostat