You can find more information about PF3D7_0618500-MDH using the following links:

Subcellular Localization

• Picture 1
• Picture 2

PDB protein strucure

• 6Y91
• 6R8G

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
2-[4-[2-[5-hydroxy-2-[(4-methoxyphenyl)methylcarbamoyl]-4-oxo-chromen-7-yl]oxyethyl]-2-methyl-anilino]-2-oxo-acetic acid	Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors(2007)
2-[4-[2-[5-hydroxy-2-[(4-methoxyphenyl)methylcarbamoyl]-4-oxo-chromen-7-yl]oxyethyl]anilino]-2-oxo-acetic acid	Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors(2007)
Atorvastatin	Antimalarial drugs and drug targets specific to fatty acid metabolic pathway of Plasmodium falciparum(2012)
ATP	Structure-function study of a Plasmodium falciparum Hsp70 using three dimensional modelling and in vitro analyses(2008)
Gossypol	An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme(2004)
Hsp70	Structure-function study of a Plasmodium falciparum Hsp70 using three dimensional modelling and in vitro analyses(2008)
Itraconazole	Antimalarial drugs and drug targets specific to fatty acid metabolic pathway of Plasmodium falciparum(2012)
Oxamic acid	Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors(2007)
PfMDH mutant	Oligomeric protein interference validates druggability of aspartate interconversion in Plasmodium falciparum(2019)
Posaconazole	Antimalarial drugs and drug targets specific to fatty acid metabolic pathway of Plasmodium falciparum(2012)
Specific substrate, suggested target	Structure and function of Plasmodium falciparum malate dehydrogenase: role of critical amino acids in co-substrate binding pocket(2009)
Suggested target	Plasmodium and host lactate dehydrogenase molecular function and biological pathways: implication for antimalarial drug discovery(2007)