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Subcellular Localization

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PDB protein strucure

• 1HN6
• 1Z40
• 3SRI
• 4R1C
• 4R1A
• 4R1B
• 4R19
• 3SRJ
• 5NQF
• 2Z8W
• 3ZWZ
• 2J5L
• 1YXE
• 2Q8B
• 2Q8A

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
20-residue peptide (r1)	Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1(2005)
5-(1H-benzimidazol-2-yl)benzene-1,3-diamine	Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials(2016)
Ama-1 antibodies	Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen 1 of Plasmodium falciparum merozoites(2003)
Ama1, pfron2sp1, pfron2sp1	Structural and functional insights into the malaria parasite moving junction complex(2012)
Chembridge id 7056672	Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide(2014)
Cycleanine	Cheminformatics Based Machine Learning Models for AMA1-RON2 Abrogators for Inhibiting Plasmodium falciparum Erythrocyte Invasion(2015)
H2n-vfaeflplfskfgsrlhilk-cooh	Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residues(2011)
Niflumic acid	Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex(2015)
N-methylation of a 20-residue peptide	Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning(2009)
Peptide gwrllgfgpassfsm	Phage-displayed peptides bind to the malarial protein apical membrane antigen-1 and inhibit the merozoite invasion of host erythrocytes(2002)
R1 (vfaeflplfskfgsrmhilk)	Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR(2014)
Ripr antibody	Bioinformatic Identification of Peptidomimetic-Based Inhibitors against Plasmodium falciparum Antigen AMA1(2014)
RON2 hairpin analogues	Structure-Activity Studies of ß-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction(2016)
Ron2l (ditqqakdigagpvascfttrmsppqqiclnsvvntals)	Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR(2014)
Structural studie, suggested target	Apical membrane antigen 1 as an anti-malarial drug target(2011)
Tetrandrine	Cheminformatics Based Machine Learning Models for AMA1-RON2 Abrogators for Inhibiting Plasmodium falciparum Erythrocyte Invasion(2015)
trRON2 (CFTTRMSPPQQIC)	Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR(2014)
ZINC28115894	Cheminformatics Based Machine Learning Models for AMA1-RON2 Abrogators for Inhibiting Plasmodium falciparum Erythrocyte Invasion(2015)
ZINC85949227	Cheminformatics Based Machine Learning Models for AMA1-RON2 Abrogators for Inhibiting Plasmodium falciparum Erythrocyte Invasion(2015)