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Subcellular Localization

• Picture 1

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(2R)-2,3-dihydroxy-3-methyl-N-(1-octyltriazol-4-yl)butanamide	Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency(2016)
(2R)-N-(1-hexyltriazol-4-yl)-2,3-dihydroxy-3-methyl-butanamide	Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency(2016)
(R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide	Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues(2018)
(R)-N-(2-(3-(2-fluorophenyl)propanamido)ethyl)-2,4-dihydroxy-3,3-dimethylbutanamide	Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum(2019)
(R,E)-4-(2,4-dihydroxy-3,3-dimethylbutanamido)buta-1,3-dien-2-oleate	Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues(2018)
2,4-dihydroxy-3,3-dimethylbutyramide	A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites(2005)
2alpha-(4-Hydroxyphenyl)-3beta-(3,5-dihydroxyphenyl)-6-[2-(4-hydroxyphenyl)ethenyl]-2,3-dihydrobenzofuran-4-ol	Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS(2021)
benzyl (R,E)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)acrylate	Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation(2018)
Coenzyme a	Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite(2007)
Furosemide	Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite(2007)
Pantothenamide	Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated(2013)
Pantothenol	Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite(2005)
STK 668036	Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway(2016)