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Subcellular Localization

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Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(ds)RNAs	Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum(2002)
Artemisinin	Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins(2016)
Dibenzyl aziridine	Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells(2005)
Dihydroartemisinin	Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins(2016)
E-64	Falcipain-1, a Plasmodium falciparum cysteine protease with vaccine potential(2007)
E64d	Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins(2016)
Leupeptin	Falcipain-1, a Plasmodium falciparum cysteine protease with vaccine potential(2007)
N-acetyl-Leu-Leu-norLeu	Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins(2016) Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins(2016)
Peptidyl epoxides	A role for the protease falcipain 1 in host cell invasion by the human malaria parasite(2002)
RNAi	Double-stranded RNA-mediated gene silencing of cysteine proteases (falcipain-1 and -2) of Plasmodium falciparum(2002)
Suggested target	The in-vitro antimalarial activity of ferrochloroquine, measured against Cambodian isolates of Plasmodium falciparum(2004)
Symplostatin	The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains(2012)
Tcmdc-135965	Thousands of chemical starting points for antimalarial lead identification(2010)
Ya29	Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites(2004)