You can find more information about histone deacetylase 1 using the following links:

Subcellular Localization

• Picture 1
• Picture 2
• Picture 3
• Picture 4
• Picture 5
• Picture 6

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(2R)-N-[(1S)-7-(hydroxyamino)-1-(m-tolylcarbamoyl)-7-oxo-heptyl]-5-oxo-pyrrolidine-2-carboxamide	Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite(2015)
(2R)-N-[(1S)-7-(hydroxyamino)-7-oxo-1-[[3-(trifluoromethyl)phenyl]carbamoyl] heptyl]-5-oxo-pyrrolidine-2-carboxamide	Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite(2015) Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite(2015)
(2S)-N-[(1S)-7-(hydroxyamino)- 7-oxo-1-(phenylcarbamoyl)heptyl]-4-oxo-azetidine-2-carboxamide	Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite(2015)
(3S,6S,9S)-6-(1-methoxy-4-oxo-3-quinolyl)-9-(6-oxooctyl)-3-sec-butyl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2(2001)
(3S,6S,9S)-6-(1-oxo-4H-naphthalen-2-yl)-9-(6-oxooctyl)-3-sec-butyl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone	Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents(2000)
(3S,6S,9S)-6-(4-methoxy-1-oxo-4H-naphthalen-2-yl)-9-(6-oxooctyl)-3-sec-butyl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone	Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents(2000)
(3S,6S,9S)-6-(4-methoxy-1-oxo-4H-naphthalen-2-yl)-9-[6-(oxiran-2-yl)-6-oxo-hexyl]-3-sec-butyl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1(2001)
(3S,6S,9S)-6-[(1-methylindol-3-yl)methyl]-9-(6-oxooctyl)-3-sec-butyl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2(2001)
(3S,6S,9S)-6-[(2-bromo-1H-indol-3-yl)methyl]-9-(6-oxooctyl)-3-sec-butyl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2(2001)
(3S,6S,9S)-9-(6-oxooctyl)-6-[[1-(pyrrolidin-1-ylmethyl)indol-3-yl]methyl]-3-sec-butyl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2(2001)
(3S,6S,9S)-9-(7-fluoro-6-oxo-octyl)-6-(4-methoxy-1-oxo-4H-naphthalen-2-yl)-3-sec-butyl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1(2001)
(3S,6S,9S)-9-(7-hydroxy-6-oxo-octyl)-6-(4-methoxy-1-oxo-4H-naphthalen-2-yl)-3-sec-butyl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1(2001)
(3S,6S,9S,12S)-3-Benzyl-6-methyl-9-[6-(oxiran-2-yl)-6-oxohexyl]-1,4,7,10-tetrazabicyclo[10.3.0]pentadecane-2,5,8,11-tetrone	Cyclic Tetrapeptide HDAC Inhibitors with Improved Plasmodium falciparum Selectivity and Killing Profile(2021)
(bis)alkylpolyamines	Valproic acid as a potential inhibitor of Plasmodium falciparum histone deacetylase 1 (PfHDAC1): an in silico approach(2015)
(E)-N-(2-Aminophenyl)-3-(4-((((3R,5aS,6R,8aS,9R,12R,12aR)-3,6,9-trimethyldecahydro12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)methyl)phenyl)acrylamide	Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin-HDAC Inhibitor Hybrids as Multitarget Drugs(2022)
(S)-2-cinnamamido-N8-hydroxy-N1-(quinolin-8-yl)octanediamid	Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors(2012)
(S)-N8-hydroxy-2-(1H-indole-2-carboxamido)-N1-(quinolin-8-yl)octanediamide	Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors(2012)
[3’-keto-MeBmt] cyclosporin D	Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy(2008) Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules(2014)
1-[3′-N-(N′-phenylurenyl)phenyl]- 3(3,4,5-trimethoxyphenyl)-2-propen-1-one	Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors(2008)
2-(2-((6-cyano-1-methyl-1H-indol-3-yl)methyl)-2,6-diazaspiro[3.4]octan-6-yl)-N-hydroxypyrimidine-5-carboxamide	Drug Repurposing of Quisinostat to Discover Novel Plasmodium falciparum HDAC1 Inhibitors with Enhanced Triple-Stage Antimalarial Activity and Improved Safety(2022)
2-(7-((5-cyano-1-methyl-1H-indol-3-yl)methyl)-2,7-diazaspiro[4.4]nonan-2-yl)-N-hydroxypyrimidine-5-carboxamide	A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1(2020)
2-aminosuberic acid	Potent antimalarial activity of histone deacetylase inhibitor analogues(2008)
2-ASA-9	Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors(2015)
2-asa-9, wr301801	Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages(2014)
3-(4-bromophenyl)-1-(4-hydroxybutylamino)-2- phenylheptan-3-ol	In silico identification of inhibitors against Plasmodium falciparum histone deacetylase 1 (PfHDAC-1)(2018)
5-azacytidine	Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents(2000)
6-[(1-Benzothiophen-2-ylformamido)oxy]-N-hydroxyhexanamide	Design and Synthesis of Novel Anti-Plasmodial Histone Deacetylase Inhibitors Containing an Alkoxyamide Connecting Unit(2017)
6-[(3S,6S,9S)-6-(4-methoxy-1-oxo-4H-naphthalen-2-yl)-2,5,8,11-tetraoxo-3-sec-butyl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecan-9-yl]hexanehydroxamic acid	Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1(2001)
Alkoxyamide	Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages(2014)
Apicidin	Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase(1996) Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents(2000) Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1(2001) Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2(2001) Histone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycle(2010) Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors(2012)
apicidin 1A	The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin(2001) Antiplasmodial drug targets: a patent review (2000 - 2013)(2016)
Apicidin A	Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents(2000)
Apicidin f	Structure elucidation and antimalarial activity of apicidin F: an apicidin-like compound produced by Fusarium fujikuroi(2013)
Aroyl-pyrrolyl-hydroxyamide	Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors(2004)
Aryltriazolylhydroxamates	Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group(2010)
Azelaic acid	Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents(2000)
azelaic bishydroxamic acid	Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents(2000) Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy(2008)
Cay10603	Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules(2014)
Chembl181459	Valproic acid as a potential inhibitor of Plasmodium falciparum histone deacetylase 1 (PfHDAC1): an in silico approach(2015)
Cherry-picked hits from the hdac-biased chemical library	Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum(2009)
Cinnamic acid	Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components(2010)
dsRNA	Inhibition of Plasmodium falciparum proliferation in vitro by double-stranded RNA directed against malaria histone deacetylase(2009)
dynasore	Antimalarial activity of the anticancer histone deacetylase inhibitor SB939(2012)
Hmba	Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents(2000)
Hydroxamic acid	Hydroxamic acid based histone deacetylase inhibitors with confirmed activity against the malaria parasite(2015)
Ketolide	Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton(2010)
LMK235	Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors(2015)
Methyl 4-({[5-(hydroxycarbamoyl)pentyl]oxy}carbamoyl)-benzoate	Design and Synthesis of Novel Anti-Plasmodial Histone Deacetylase Inhibitors Containing an Alkoxyamide Connecting Unit(2017)
MS-275	Potent antimalarial activity of histone deacetylase inhibitor analogues(2008)
N-(2-(Cyclohexylamino)-2-oxoethyl)-N-(4-(hydrox-ycarbamoyl)benzyl)-2,4-dimethylbenzamide	Investigation of the in vitro and in vivo efficacy of peptoid-based HDAC inhibitors with dual-stage antiplasmodial activity(2020)
N-(2-(Cyclohexylamino)-2-oxoethyl)-N-(4-(hydroxycarbamoyl)benzyl)-4-isopropylbenzamide	Histone deacetylase inhibitors with high in vitro activities against Plasmodium falciparum isolates collected from Gabonese children and adults(2019)
N-(2,5-dimethylphenoxy)-4-(hydroxycarbamoyl)benzamide	Design and Synthesis of Terephthalic Acid-Based Histone Deacetylase Inhibitors with Dual-Stage Anti-Plasmodium Activity(2017)
N-(4-(2-(Diethylamino)ethylcarbamoyl)phenyl)-N8 -hydroxyoctanediamide	Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites(2021)
N-[4-(3-amino-4-methoxyphenyl)-1,3-thiazol-2-yl]-N'-hydroxyoctanediamide	In silico identification of inhibitors against Plasmodium falciparum histone deacetylase 1 (PfHDAC-1)(2018)
N1-(4-((4-((1-(4-Fluorobenzyl)piperidin-4-yl)amino)-6,7-dimethoxyquinazolin-2-yl)amino)phenyl)-N8-hydroxyoctanediamide hydrochloride	Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor(2019)
N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide	Discovery of Novel Plasmodium falciparum HDAC1 Inhibitors with Dual-Stage Antimalarial Potency and Improved Safety Based on the Clinical Anticancer Drug Candidate Quisinostat(2021)
N-hydroxy-4-((4-(4-(pyrrolidin-1-ylmethyl)phenyl)-1H-1,2,3-triazol-1-yl)methyl)benzamide	Discovery of FNDR-20123, a histone deacetylase inhibitor for the treatment of Plasmodium falciparum malaria(2020)
N-hydroxy-4-(3-methyl-2-phenylbutanamido)benzamide	Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice(2021)
Nonpeptide macrocyclic	A structure-activity relationship study of the antimalarial and antileishmanial activities of nonpeptide macrocyclic histone deacetylase inhibitors(2010)
Panobinostat	Chemical signatures and new drug targets for gametocytocidal drug development(2014) Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites(2015) Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors(2015) An ELISA method to assess HDAC inhibitor-induced alterations to P. falciparum histone lysine acetylation(2020)
Proteins predicted to be involved in cell cycle regulatory network	Activity of Epigenetic Inhibitors against Plasmodium falciparum Asexual and Sexual Blood Stages(2020)
Romidepsin	Chemical signatures and new drug targets for gametocytocidal drug development(2014) Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites(2015)
Saha	Potent antimalarial activity of histone deacetylase inhibitor analogues(2008) Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy(2008) Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules(2014) Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors(2015)
SAHA(E)-3-{2-butyl-1-[2-(diethylamino) ethyl]benzimidazol-5-yl}prop-2-ene hydroxamic acid	Antimalarial activity of the anticancer histone deacetylase inhibitor SB939(2012)
Salicylhydroxamic acid	Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents(2000)
Santacruzamate a	Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp(2013)
Sb939	Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages(2014)
SBHA	Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents(2000) Potent antimalarial activity of histone deacetylase inhibitor analogues(2008) Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy(2008) Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors(2015)
SHA	Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors(2015)
Sirtinol	Potent antimalarial activity of histone deacetylase inhibitor analogues(2008)
Sphingosine-1-Phosphate	Host-Erythrocytic Sphingosine-1-Phosphate Regulates Plasmodium Histone Deacetylase Activity and Exhibits Epigenetic Control over Cell Death and Differentiation(2023)
Suberic acid	Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents(2000)
Suberoylanilide	Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors(2004)
Suberoylanilide hydroxamic acid	Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors(2004)
Suberoylanilide hydroxamic acid	Valproic acid as a potential inhibitor of Plasmodium falciparum histone deacetylase 1 (PfHDAC1): an in silico approach(2015)
suberylanilide hydroxamic acid	Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors(2012)
Triazolylphenyl	A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum(2008)
Trichostatin	Antimalarial and antileishmanial activities of aroyl-pyrrolyl-hydroxyamides, a new class of histone deacetylase inhibitors(2004)
Trichostatin a	Potent antimalarial activity of histone deacetylase inhibitor analogues(2008) Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors(2012) Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages(2014) Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites(2015)
tubacin	Potent antimalarial activity of histone deacetylase inhibitor analogues(2008)
Tyrocidine b	Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents(2000)
Verlindamycin	Valproic acid as a potential inhibitor of Plasmodium falciparum histone deacetylase 1 (PfHDAC1): an in silico approach(2015)
Vorinostat	Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages(2014)
WR301801	Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors(2015)
WR301839	Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors(2015)
WR301858	Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors(2015)
WR308292	Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors(2015)