You can find more information about PF3D7_0104400-4-hydroxy-3-methylbut-2-enyl%20diphosphate%20reductase using the following links:

PDB protein strucure

• 4N7B

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(e)-4-mercapto-3-methylbut-2-en-1-yl diphosphate	Inhibition of IspH, a [4Fe-4S]2+ enzyme involved in the biosynthesis of isoprenoids via the methylerythritol phosphate pathway(2013)
2-dimethylamino-ethyl-diphosphate	An in silico structural insights into Plasmodium LytB protein and its inhibition(2015)
3-methyl-3,4-epoxybutyl diphosphate	An in silico structural insights into Plasmodium LytB protein and its inhibition(2015)
5-((hydroxymethyl)-o-pyrophosphoryl)uracil	An in silico structural insights into Plasmodium LytB protein and its inhibition(2015)
5-diphosphomevalonic acid	An in silico structural insights into Plasmodium LytB protein and its inhibition(2015)
Competitive inhibition, suggested target	Methylerythritol phosphate pathway to isoprenoids: kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum(2013)
Hammerhead ribozyme	Inhibition of Plasmodium falciparum ispH (lytB) gene expression by hammerhead ribozyme(2007)
Hmbpp	Inhibition of the 4Fe-4S Proteins IspG and IspH: an EPR, ENDOR and HYSCORE Investigation(2014)
In silico, suggested target	In silico prediction of antimalarial drug target candidates(2012)
Pyridoxal Diphosphate	Exploration and validation of diphosphate-based Plasmodium LytB inhibitors using computational approaches(2019)
Suggested target	Structure of the (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase from Plasmodium falciparum(2013) Utilizing a dynamical description of IspH to aid in the development of novel antimicrobial drugs(2013)