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Subcellular Localization

• Picture 1

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
3,6-diamino-4-(2-bromophenyl)-2-(3,4-dichlorobenzoyl)thieno[2,3-b]pyridine-5-carbonitrile	First report on exploring classification and regression based QSAR modelling of Plasmodium falciparum glycogen synthase kinase (PfGSK-3) inhibitors(2015)
3,6-diamino-4-(2-bromophenyl)-2-(3-chlorobenzoyl)thieno[2,3-b]pyridine-5-carbonitrile	First report on exploring classification and regression based QSAR modelling of Plasmodium falciparum glycogen synthase kinase (PfGSK-3) inhibitors(2015)
3,6-diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles	3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3(2013)
3,6-diamino-4-(thiophen-2-yl)thieno[2,3-b]pyridine-2,5-dicarbonitrile​	First report on exploring classification and regression based QSAR modelling of Plasmodium falciparum glycogen synthase kinase (PfGSK-3) inhibitors(2015)
3,6-diamino-4-o-tolylthieno[2,3-b]pyridine-2,5-dicarbonitrile	First report on exploring classification and regression based QSAR modelling of Plasmodium falciparum glycogen synthase kinase (PfGSK-3) inhibitors(2015)
4-((5-Chloro-4-(5-methylthiophen-2-yl)pyrimidin-2-yl)amino)-N- (3-morpholinopropyl)benzamide (23f)	Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial Pf GSK3/ Pf PK6 with Activity against Blood Stage Parasites In Vitro(2022)
4-[(6-methoxy-1-benzofuran-2-yl)carbonyl]benzonitrile	Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors(2021)
4-phenylthieno[2,3-b]pyridine	Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines(2019)
Actinomyces strain FH025	Anti-malarial Activities of Two Soil Actinomycete Isolates from Sabah via Inhibition of Glycogen Synthase Kinase 3ß(2016)
Actinomyces strain H11809	Anti-malarial Activities of Two Soil Actinomycete Isolates from Sabah via Inhibition of Glycogen Synthase Kinase 3ß(2016)
CHIR 99021	GSK3 inhibitors: development and therapeutic potential(2004)
Curcumin	The Antimalarial Effect of Curcumin Is Mediated by the Inhibition of Glycogen Synthase Kinase-3ß(2017)
In silico, suggested target	Malarial kinases: novel targets for in silico approaches to drug discovery(2013)
indirubin-30-monoxime	Targeting the Ubiquinol-Reduction (Q i) Site of the Mitochondrial Cytochrome bc 1 Complex for the Development of Next Generation Quinolone Antimalarials(2022)
Indirubins	Using topological indices to predict anti-Alzheimer and anti-parasitic GSK-3 inhibitors by multi-target QSAR in silico screening(2010)
Manzamine a	2-N-Methyl modifications and SAR studies of manzamine A(2008)
Meridians	Using topological indices to predict anti-Alzheimer and anti-parasitic GSK-3 inhibitors by multi-target QSAR in silico screening(2010)
Paullone	Using topological indices to predict anti-Alzheimer and anti-parasitic GSK-3 inhibitors by multi-target QSAR in silico screening(2010)
Quinazolinone	Selective inhibitors of Plasmodium falciparum glycogen synthase-3 (PfGSK-3): New antimalarial agents?(2015)
Structure-based design, suggested target	Generation and evaluation of a homology model of PfGSK-3(2009)