You can find more information about PF3D7_0316600-FNT using the following links:

Subcellular Localization

• Picture 1
• Picture 2

PDB protein strucure

• 6VQQ
• 6VQR

Affecting Drugs
Drug Name	PubMed Articles (year of publication)
(Z)-4,4,5,5,5-pentafluoro-3-hydroxy-1-(2-hydroxy-4-methoxyphenyl)pent-2-en-1-one	Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents(2021)
(Z)-4,4,5,5,5-pentafluoro-3-hydroxy-1-(pyridin-3-yl)pent-2-en-1-one	Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism(2021)
2-Hydroxy-7-methoxy-2-(1,1,2,2,2-pentafluoroethyl)-3H-chromen-4-one	Structural basis of transport and inhibition of the Plasmodium falciparum transporter PfFNT(2021) Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism(2021)
2-Hydroxy-7-methoxy-2-(1,1,2,2,3,-heptafluoroethyl)-2,3-dihydro-4H-chromen-4-one	Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale(2017)
2-Hydroxy-7-methoxy-2-(1,1,2,2-tetrafluoroethyl)-2,3-dihydro-4H-chromen-4-one	Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale(2017)
4,4,5,5,5-pentafluoro-3-hydroxy-1-(3-pyridyl)pent-2-en-1-one	Introduction of scaffold nitrogen atoms renders inhibitors of the malarial L-lactate transporter, PfFNT, effective against the Gly107Ser resistance mutation(2020)
7-chloro-2-hydroxy-2-(1,1,2,2,2-pentafluoroethyl)chroman-4-one	Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale(2017)
7-ethoxy-2-hydroxy-2-(1,1,2,2,2-pentafluoroethyl)chroman-4-one	Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale(2017)
Borrelidin	A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum(2015)
Enzyme characterization, suggested target	A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum(2015)
MMV000972	The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens(2017)
MMV007839	Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale(2017) The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens(2017)
Pentafluoro-3-hydroxy-pent-2-en-1-ones	Pentafluoro-3-hydroxy-pent-2-en-1-ones potently inhibit FNT-type lactate transporters from all five human-pathogenic Plasmodium species(2020)